Calcitriol gel pill instructions, the role and efficacy of calcitriol soft capsules

Updated on healthy 2024-08-12
4 answers
  1. Anonymous users2024-02-16

    Hello dear! The function and efficacy of calcitriol softgels: Softgels have the effect and effect of regulating calcium absorption.

    Calcitriol is one of the most important active metabolites of vitamin D, which promotes intestinal calcium absorption and regulates bone mineralization. Indications: 1. Postmenopausal and senile osteoporosis.

    2. Chronic renal failure, especially renal osteodystrophy in hemodialysis patients. 3. Postoperative hypoparathyroidism. 4. Idiopathic hypoparathyroidism.

    5. Pseudohypoparathyroidism. 6. Vitamin D-dependent rickets. 7. Low blood phosphate vitamin D-resistant rickets.

  2. Anonymous users2024-02-15

    Calcitriol InstructionsDrug NameCalcitriolEnglish NameCalcitriolAlias Dihydroxyvitamin D3; Dihydroxycholecalciferol; Calcitriol; Calcitriol; Luo calcium; irrigation purity; Trihydroxyvitamin D3; Dihydroxyvitamin D3; dihydroxyvitamind3;Rocaltrol Classification Endocrine System Drugs "Parathyroid and Bone Metabolic Diseases Drug Dosage Form 1Capsule:; 2.

    Irrigation pure, injection: 1 g (1 ml), 2 g (1 ml). Pharmacological effects of calcitriol Calcitriol is one of the most important active metabolites of vitamin 1, 25d3.

    This metabolite is usually formed within the kidneys. In recent years, it has been discovered that calcitriol can also be produced outside the kidney, and it has been confirmed that 1 hydroxylase can be produced in the supernatant of placenta, monocytes, macrophages, amur-deficient tumor cells, lymph nodes and keratinocytes of sarcoidosis patients. The precursor of calcitriol is 25-hydroxycholecalciferol (alfacalcalcalciferol).

    Calcitriol has the effect of promoting calcium absorption in the small intestine and regulating the transport of inorganic salts in bone. In patients with significant renal insufficiency, especially those requiring long-term hemodialysis, endogenous calcitriol synthesis will be greatly reduced, or even almost stopped, resulting in renal osteodystrophy. Oral calcitriol can cause the intestine to absorb calcium normally, so it can correct low blood calcium, reduce bone and muscle pain, reduce or normalize the increased plasma sulfine phosphatase, and reduce the increased plasma parathyroid gland concentration to normalize, thereby promoting bone mineralization.

    Calcitriol also accelerates the maturation of bone collagen. In recent years, it has also been found that it plays an important role in cell proliferation, differentiation and the immune system. The pharmacokinetics of calcitriol are rapidly absorbed orally, the peak time of plasma drug concentration is 3 6h, and the urine calcium level will increase after 7h, and the biological response is related to the dose, and the plasma half-life is.

    It is metabolized and excreted in bile and urine. Calcitriol is indicated for renal osteodystrophy in patients with chronic renal failure, particularly those requiring long-term hemodialysis. Spontaneous and pseudohypothyroidism after surgery.

    Vitamin D33-dependent rickets and hypophosphatemia vitamin D-resistant rickets. In recent years, it has also been used for psoriasis and other diseases. Contraindications to calcitriol are contraindicated in diseases related to hypercalcemia.

    Note 1Pregnant women and children should use with caution. 2.

    According to blood calcium. For details, see Encyclopedia entry: Calcitriol [ Last revised on 2016 9 22 22:18:18 A total of 1853 words ] The following results are automatically matched, and it is not excluded that there will be content that is not related to the topic, please distinguish by yourself.

  3. Anonymous users2024-02-14

    Synonyms】 butylene; calciferol; calciferol; Anti-rickets, vitamin D2 foreign name] vitamin D2

    Indications] for the prevention and treatment of rickets, osteomalacia and infantile tetany

    1.**Rickets: Oral:

    2,500 5,000 units a day, and after about 1 or 2 months, when symptoms begin to disappear and hail grips, switch to prophylactic doses. If oral injection is not possible and severe patients are given intramuscularly, 300,000 600,000 units per time, and if necessary, intramuscular injection once after 1 month, the total amount of 2 times does not exceed 900,000 units. If there is a calcium deficiency when taking vitamin D, 10 calcium chloride should be taken orally once 5 10ml, 3 times a day, 2 3 days.

    2.Infantile tetany: oral:

    2,000 5,000 units a day, 400 units per day after 1 month. 3.Prevention of vitamin D deficiency:

    Breastfed infants are 400 units a day, and if necessary, 400 units a day of chain starvation during pregnancy.

    Note 1Taking a large amount of long-term consumption can cause hypercalcemia, loss of appetite, vomiting, diarrhea, and even ossification of soft tissue ectopesis. If renal function is impaired, urine, proteinuria, and renal function may be reduced.

    This product and calcium should be stopped in time. Excessive use in pregnant women can cause fetal valve aortic stenosis, vascular damage, parathyroid function inhibition and long-term hypoglycemic convulsions in newborns, so it should be noted. In the commercially available cod liver oil preparation, it contains a large amount of vitamin A, and long-term use in large quantities is easy to cause chronic poisoning of vitamin A, so it is advisable to use pure vitamin D preparations in case of rickets.

    In addition, injections are more toxic than oral administrations. 2.Long-term use and too much in infants and young children can cause physical and mental retardation, ugly face, kidney failure and even death.

    3.It can also cause polydipsia, polyuria, and mental changes. 【Specifications】 Gel pills:

    Each capsule contains 10,000u. Injection: 400,000 U 1ml.

    Colloidal calcium injection: 1ml, 10ml; Each milliliter contains vitamin D2 50,000 U, colloidal calcium free.

  4. Anonymous users2024-02-13

    High blood calcium is closely related to the ** of this product. Studies in patients with uremic osteodystrophy have shown that high blood calcium is found in up to 40% of patients who use calcitriol**. Dietary changes (e.g., increased intake of dairy products) leading to a rapid increase in calcium intake or uncontrolled use of calcium preparations can lead to hypercalcemia.

    Patients and their families should be informed that the prescribed diet must be strictly adhered to, and they should be taught how to recognize the symptoms of hypercalcemia. Once the blood calcium concentration is 1 mg 100 ml higher than the normal value (9-11 mg 100 ml, or 2250-2750 umol L), or the serum creatinine rises to greater than 120 umol L, you should immediately stop taking this product until the blood calcium is normal.

    In patients with normal renal function, chronic hypercalcemia may be associated with increased serum creatinine. Bedridden patients, such as postoperative bedridden patients, are more likely to develop hypercalcemia.

    Calcitriol increases blood inorganic phosphorus levels, which is beneficial for hypophosphatemia patients, but beware of the dangers of abnormal calcium precipitation in patients with renal failure. In such cases, blood phosphate is maintained at normal levels (2-5 mg 100 mL or MMOL L) by taking an appropriate amount of phosphate binder orally or by reducing phosphorus intake.

    Patients suffering from vitamin D-resistant rickets (familial hypophosphatemia) should continue oral phosphorus preparations when taking this product**. However, it must be taken into account that this product may promote the absorption of phosphorus in the intestine, and this effect may reduce the need for phosphorus intake. Therefore, it is necessary to regularly perform laboratory tests such as blood calcium, phosphorus, magnesium, alkaline phosphatase, and urine calcium and phosphorus quantification within 24 hours.

    During the stable period of this product**, blood calcium should be measured at least twice a week.

    Because calcitriol is the most potent vitamin D metabolite available, it does not need to be used in combination with other vitamin D preparations to avoid hypervitamin Demia.

    If a patient switches from vitamin D2 to calcitriol, it may take several months for blood vitamin D2 levels to return to basal levels.

    Patients with normal renal function must avoid dehydration when taking this product, so appropriate water intake should be maintained.

    Effect on driving vehicles and operating machinery: Based on the pharmacodynamic properties of the reported adverse reactions, it is speculated that this product is safe or has little effect on driving vehicles and operating machinery.

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