Why does MND cause slurred speech?

Motor neuron disease (MND) is a group of chronic, progressive neurodegenerative diseases of the anterior horn cells of the spinal cord, motor neurons of the brainstem, pyramidal cells of the cortex, and pyramidal tract of the spinal cord by unknown choice. The first symptoms of the disease can be varied. Most patients have asymmetrical local limb weakness, such as stiff walking, procrastination, easy falling, and inflexible finger movement.

Bulbar symptoms such as dysphagia and dysarthria. A small number of patients present with respiratory symptoms. As the disease progresses, muscle atrophy, "flesh beating" sensation (i.e., fasciculations), cramps, and expansion to other muscles in the body gradually appear, and in the later stage of the disease, in addition to eye movements, all locomotor systems of the whole body are involved, involving respiratory muscles, dyspnea, respiratory failure, etc.

At present, the disease cannot be delayed, and the disease can only be delayed and self-care ability can be improved.

Early symptoms are mild and can be easily confused with other diseases. Patients may only feel some symptoms such as weakness, flesh jumping, and fatigue easily, and gradually progress to generalized muscle atrophy and difficulty swallowing. Respiratory failure develops.

According to the clinical symptoms, it can be roughly divided into two types:

1.Limb-onset type.

Symptoms begin with progressive atrophy and weakness of the muscles in the limbs, and finally respiratory failure.

2.Bulbar onset.

Difficulty swallowing and speaking begins with early progression, and respiratory failure soon progresses.

According to the situation you described, there is no effective ** method for motor neuron disease, you need to actively follow the doctor's instructions to give nutritional nerve drugs and support the symptoms**, it is recommended to choose a regular public tertiary hospital for diagnosis and treatment, and usually relax.

Motor neuron disease (MND) is a chronic degenerative disease of the nervous system, which progressively worsens once the course of the disease occurs, and the clinical manifestations are lesions of upper motor neurons and lower motor neurons at the same time, or in different combinations. Characteristic manifestations are muscle weakness and muscle atrophy of the skeletal muscles, with positive pyramidal tract signs or bulbar palsy, unaffected sensory system, and normal bowel and bowel function. MND can be divided into 4 common types:

1. Amyotrophic lateral sclerosis, which is one of the most common ones, is also known as ALS, which involves both upper and lower motor neurons at the same time. 2. Progressive amyotrophy, which is relatively rare, is dominated by motor neuron damage. 3. Progressive bulbar palsy, mainly bulbar palsy, mainly progressive hoarseness, difficulty swallowing, choking on drinking water and other symptoms.

4. Primary lateral sclerosis, the rarest, symmetrical stiffness and weakness of both lower limbs, and a more characteristic scissor gait when walking.

Motor neuron degenerative disease is a chronic neuronal cannibalization disease, which is difficult to heal in the later stage of the disease, and when its onset is severe, it can invade the anterior horn cells of the spinal cord and the nerve nucleus of the brainstem and the pyramidal cells of the motor cortex of the brain, resulting in dyspnea and dysphagia and life-threatening, about 5% and 7% of patients are caused by abnormal genetic immunity or viral infection. The remaining patients** are unknown, but have been reported to be related to heavy metals, chemical poisoning, and the surrounding environment. The efficacy of simple drugs ** is not good, the condition is difficult to control, and the disease leads to neurotrophic disorder and gradually aggravates the secondary deficiency neurological impairment, so that the neurological symptoms are further aggravated.

Finally, leading to paralysis of the cervical spine is a group of chronic progressive degenerative diseases that mainly damage the anterior horn of the spinal cord, the motor nucleus of the cranial nerve and the pyramidal tract. Symptoms such as muscle atrophy and muscle weakness are the most common. Such as:

Slurred speech, difficulty swallowing, difficulty moving, difficulty breathing, etc. Eventually, the patient died of inability to breathe while he was conscious. Therefore, this kind of patient is also called "ALS".

The main manifestations of this disease, the earliest symptoms are mostly seen in the hand part, the patient feels weakness, stiffness, clumsiness of finger movement, gradual atrophy of hand muscles, and fasciculations can be seen. The distal limbs show progressive muscle atrophy, and more than half of the cases show atrophy of the thenar muscle of one upper limb and hand in the early stage, and then extend to the forearm muscles, even the pectoralis major muscle, the back muscles can also be atrophied, the calf muscles can also be atrophied, the muscles are atrophied, the limbs are weak, the muscle tone is high (stretching sensation), the muscle is tremor, the difficulty of moving, breathing and swallowing disorders and other symptoms. In the case of early pathological bilateral pyramidal tracts, spastic paraplegia of both lower extremities may be present.

The early symptoms of MND are not particularly obvious, but as the disease progresses, different symptoms of muscle weakness, muscle atrophy and dysphagia will gradually appear, and in the later stages, you may have slurred speech and inability to speak.

Yes, due to the unclear motor neuron disease, there is no special and effective targeted means and drugs in Western medicine, and the motor neuron disease is only symptomatic, and the effect is not good, and the development of the disease cannot be stopped. The detoxification effect of pure Chinese medicine prescriptions, combined with the synthesis of the five elements, can achieve twice the result with half the effort, and the efficacy is far better than that of conventional Chinese and Western medicine.

Western**. There is no special method, a large number of B vitamins, energy mixture, etc. can be given or injected at acupuncture points with 654-2 and Galantamine injection.

Chinese medicine**. Motor neuron disease (MND) is a syndrome of impotence in traditional Chinese medicine, which is a syndrome of sluggish and weak limb muscles. Traditional Chinese medicine believes that the kidney is the innate foundation, the main essence is stored, and the bone is the marrow. In traditional Chinese medicine, it is most closely related to the kidneys, with insufficient congenital endowment, lack of sperm and blood, and inability to nourish muscles, muscles and bones, and gradually muscle weakness and atrophy.

At the same time, the spleen and stomach are the foundation of the day after tomorrow, metamorphosis generates qi and blood, nourishes the five internal organs, muscles, muscles and bones, and the spleen is the main muscle, the spleen and stomach are weak, the biochemistry of qi and blood is insufficient, and the muscles are not nourished, so the muscles are atrophied and weak.

People with motor neurons develop respiratory failure in advanced stages, sometimes with sudden onset of breathing difficulties. Patients at this stage need to go to the hospital for a pulmonary function test, and one can be used if there is a problem. Bilevel positive pressure ventilation, which is convenient for home use, is severe.

Even if it is difficult to eat or drink and choke, it is necessary to go to the hospital in time to be placed with a gastric tube or undergo surgery to maintain the patient's nutritional status. Be an athlete. Most patients with respiratory disorders are intubated or tracheostomy, among which non-cleaning ventilation is more commonly assisted by ventilator ventilation to regularly monitor the patient's ventilation function, in addition.

Pray that Zheng Ya can be used to deal with the condition of hypoventilation at night, reduce the mortality rate of patients, and improve the quality of life.

The exact nature and pathogenesis of motor neuron disease are unknown. It may cause the accumulation of toxic substances in the nervous system for various reasons, especially the increase of free radicals and excitatory amino acids, and damage nerve cells and cause disease.

First, the main **.

1. Genetic factors: most of the motor neuron disease is sporadic, a few have a family history, and the mode of transmission is mainly autosomal dominant inheritance. The most common causative gene is the copper (zinc) superoxide dismutase (SOD-1) gene on chromosome 21.

2. Infection and immunity: Some researchers believe that the onset of the disease may be related to poliovirus, enterovirus, and human immunodeficiency virus (HIV), and when the infection invades neurons, patients will have corresponding clinical manifestations.

3. Metallic elements: The onset of motor neuron disease may be related to certain metals, such as lead, mercury, aluminum, etc., and the difference in the content of metallic elements in the environment may also be the reason for the high incidence of geography in some regions.

4. Nutritional disorders: Some researchers have found that vitamin B1 and vitamin B1 monophosphate in the plasma of patients with amyotrophic lateral wax sclerosis (ALS) are reduced, which may lead to normal metabolic disorders of neurons, which in turn leads to amyotrophic lateral sclerosis.

5. Neurotransmitters: The level of inhibitory neurotransmitter GABA in the cerebrospinal fluid of ALS patients is significantly reduced, while norepinephrine is increased, and the more severe the disease, the more obvious this change is, and some studies have shown that the neurocytotoxic effect of excitatory amino acids (mainly glutamate and aspartic acid) plays an important role in the pathogenesis of ALS.

2. Predisposing factors.

1. Trauma: The human body may cause damage to the wheel or nerve after trauma, and then the corresponding symptoms appear, and most patients with motor neuron disease have a history of trauma of varying degrees.

2. Excessive physical labor: some data show that miners, heavy manual laborers, etc. have a greater chance of suffering from motor neuron disease, because through excessive physical labor, many metabolites in the body cannot be eliminated from the body in time, and the functional metabolism of nerves will also be damaged to varying degrees.

Yes, if it develops to a later stage, it may not be able to speak.

1. Difficulties in daily life: In the middle of the course of the disease, there are serious obstacles in the hands or feet, or hands and feet at the same time, and they are unable to take care of themselves, such as being unable to walk, dress, and hold dishes and chopsticks on their own, and their speech has been slightly unclear.

2. Dyspnea: If the patient chooses tracheostomy when he or she has difficulty breathing, he or she needs to be admitted to a regional respiratory center or receive home care, and if he refuses to use a respirator, he or she needs the assistance of a palliative care team to face death safely.

3. Dysphagia: The course of the disease has entered the middle and late stages, speech has been seriously unclear, limbs are almost completely weak, and even liquid food is easy to choke when eating, if it is not inserted into a nasogastric tube, it often leads to aspiration pneumonia.

4. Symptom onset: In the early stage of the disease, there may be a sudden inability to hold chopsticks, or occasionally fall for no reason while walking, without any obvious symptoms.

5. Difficult period of work: this has obvious weakness of hands and feet, and even atrophy, although life can still take care of itself, but obstacles have occurred in the work workplace, at this time need to take more rest, so as not to aggravate the disease.

In the early stages of MND, the symptoms are relatively mild, and patients may experience symptoms such as fatigue, muscle weakness, and flesh beating, which can easily be confused with other diseases due to the lack of specificity of the symptoms. As MND progresses, patients develop generalized muscle weakness, generalized muscle atrophy, and dysphagiaDifficulty speakingand other symptoms, eventually respiratory failure will occur.

Mixed form of upper and lower motor neuron disease. Usually the first symptom is hand muscle weakness and atrophy, which generally starts from one side and then spreads to the opposite side, and with the development of the disease, there are mixed symptoms of upper and lower motor neuron damage, which is called amyotrophic lateral sclerosis. In the late stage of the disease, the muscles of the whole body are emaciated and atrophied, so that they cannot raise their heads, have difficulty breathing, and are bedridden.

The disease usually occurs between the ages of 40 and 60, and about 5 to 10% have a family history, and the course of the disease varies in speed and progression.

Motor neuron disease (MND) is commonly associated with limb damage, difficulty swallowing, slurred speech, choking on water, and gradual loss of motor ability. After diagnosis, patients need to be actively treated with anti-excitable amino acid toxicants under the guidance of a doctor** and, if necessary, surgery**.

Motor neuron disease is a group of progressive lesions selectively involving motor nerve cells in the anterior horn of the spinal cord, cranial nerves in the brainstem, motor nerve nucleus, and pyramidal cells in the motor cortex of the brain, with different combinations of muscle weakness and muscle atrophy, bulbar paralysis such as dysphagia, unclear speech, and pyramidal tract signs, such as limb antagonism and spasm.

Motor neuron disease is also one of the common neurological diseases, and the common clinical types are amyotrophic and lateral sclerosis. There are two main categories of progressive spinal muscular atrophy. Patients have symptoms of muscle atrophy, muscle weakness, and fasciculations.

The most common form of motor neuron disease is also called amyotrophic lateral sclerosis, or ALS. Motor neurons dominate the movement of our muscles. When motor neurons are diseased, the muscles will slowly atrophy and die, which will invade the respiratory system, resulting in paralysis of the limbs and difficulty in swallowing and breathing.

Amyotrophic means:"No muscle nutrition", which refers to the loss of signals transmitted from nerves to muscles. Lateral means"Side", which refers to the location of the spinal cord injury. Sclerosis means:"Hardening", which refers to the sclerotic properties of the spinal cord in patients with mid-to-late ALS.

Motor neuron disease (MND) is a group of chronic progressive degenerative diseases that mainly damage the anterior horn of the spinal cord, the motor nucleus and the pyramidal tract of the cranial nerve. Paralysis caused by upper and/or lower motor neuron damage is the main clinical manifestation, and the combination of upper and lower motor neuron damage is the most common. The disease** is still unknown.

Although many studies have put forward hypotheses that viral infection, abnormal immune function, genetic factors, heavy metal poisoning, nutritional metabolism disorders, and environmental factors cause the disease, none of them have been confirmed. The disease is a progressive disease, the average course of amyotrophic lateral sclerosis is about 3-5 years, and those with rapid progress can even die within 1 year after the onset of the disease, and the course of slow progress can sometimes reach more than 10 years. Motor neuron disease is on a par with cancer and AIDS.

As long as the patient suffers from this disease, the muscles first atrophy, and finally the patient dies due to the inability to breathe while the patient is conscious.

Therefore, this kind of patient is also called "ALS". Pathology: Nerve cells in the anterior horn of the spinal cord and the motor nucleus of the cranial nerve of the bridge extension are significantly reduced and degenerated.

Clinical manifestations: Paralysis is the main manifestation caused by clinical above and/or lower motor neuron damage, among which upper and lower motor neuron combined with damage is the most common, and the main manifestation is muscle atrophy and weakness in the affected area.