What did the whole process of C reactive protein react to

C-reactive protein is an extremely sensitive indicator of acute phase reaction, which can be used as an auxiliary basis for the diagnosis of many diseases.

Human C-reactive protein refers to proteins that rise sharply in the plasma (acute proteins) when the body is infected or tissue damaged. CRP can activate complement and enhance the phagocytosis of phagocytic cells and play a role in opsonization, thereby removing pathogenic microorganisms and tissue cells that invade the body, such as injury, necrosis and apoptosis, and play an important protective role in the body's innate immune process. CRP has been studied for more than 70 years, and the traditional view is that CRP is a non-specific inflammatory marker, but research in the past decade has revealed that CRP is directly involved in inflammation and atherosclerosis and other cardiovascular diseases, and is the most powerful predictor and risk factor for cardiovascular disease.

C-reactive protein (CRP) is an important acute-phase reactive protein in humans, and the concentration in the acute phase can be increased by thousands of times. In addition, there is growing evidence that CRP is not only an inflammatory marker, but itself directly involved in the inflammatory process. The clinical significance of CRP is the same as that of erythrocyte sedimentation rate, but it is not affected by factors such as red blood cells, Hb, lipids, and age, and is a good indicator of response to inflammatory infection and efficacy.

The rheumatoid active phase is markedly increased, parallel to the rapid erythrocyte sedimentation rate, but appears earlier than the rapid erythrocyte sedimentation rate and disappears more quickly. The higher the CRP content, the higher the lesion activity. During the recovery of inflammation, if CRP is positive, it indicates that there is still the possibility of sudden onset of clinical symptoms; When CRP that has turned negative after stopping hormones is positive, it indicates that lesion activity is continuing.

During remission of inflammation and with antirheumatic drugs, negative or disappearance is more rapid than erythrocyte sedimentation rate and is less susceptible to erythrocyte sedimentation rate in anemia and heart failure. Positive CRP can also be seen in pneumonia, nephritis, malignant tumors and acute infection, trauma and tissue necrosis, myocardial infarction, cardiac insufficiency, multiple myeloma, leukemia, cholelithiasis, hepatitis, dysentery, rheumatic fever, PM, PSS, polyarteritis nodosa, SLE, tuberculosis and inoculation. You may have rheumatoid arthritis and be in a more active phase.

"C-reactive eggs" and "full C-reactive proteins" are not exactly one substance.

The whole process of C-reactive protein is a "full-scale measurement" of C-reactive protein, including common C-reactive protein and hypersensitive C-reactive protein.

Common C-reactive protein is often used clinically as a preferred marker for differentiating bacterial and viral infections, and its detection range is generally 10 to 200 mg L, and it is not sensitive to low-level inflammatory responses (e.g., cardiovascular events) within the normal range. Hypersensitive C-reactive protein uses immunoluminescence and other technologies to extend the detection sensitivity to a lower limit, which makes the determination of C-reactive protein at the concentration more accurate, because it represents a low-level inflammatory response, and is more used in the judgment of cardiovascular diseases.

C-reactive protein is a normal component of human serum protein, and it is an acute phase (phase) protein, also known as C-reactive protein (CRP). Normal reference value 10mg l.

It is significantly increased in the presence of inflammation and tissue damage. (1) In the active phase of rheumatic diseases and nephritis, such as rheumatic fever, rheumatoid arthritis, systemic lupus erythematosus, seronegative spondyloarthropathy, systemic sclerosis, myositis, dermatomyositis, vasculitis, etc., CRP generally increases significantly, while the inactive phase becomes normal. If the drug is elevated again after discontinuation, it is called rebound phenomenon, and it should continue at this time.

2) In bacterial, viral, some mold and parasitic infections, CRP measurement can be used as an auxiliary diagnostic index.

3) CRP is elevated in myocardial infarction and normal in angina, which is helpful for clinical differential diagnosis.

4) There is a high positive rate in patients with primary liver cancer, various metastatic cancers and sepsis.

5) It can be used as an early indicator to judge whether postoperative patients are complicated by inflammation and tissue necrosis. CRP increased rapidly in 6 to 8 hours after surgery-induced tissue injury, reaching the highest concentration at 48 72 hours. As long as tissue necrosis is present, CRP remains at a high level.

If there are no complications after surgery, it will decrease rapidly after 3 to 4 days.

6) It can reflect the area, depth and degree of tissue destruction of burn patients, which is helpful for estimating the prognosis and selecting the most appropriate time for scab removal and skin grafting.

7) CRP can be significantly increased during kidney transplant rejection.

In short, although CRP is a non-specific index, if it can be combined with clinical manifestations and other examination results, it has certain significance for the diagnosis, prognosis observation and evaluation of many diseases. The clinical significance of CRP is similar to that of ESR in some aspects, but it is more valuable than ESR in clinical diagnosis because it appears early after onset, decreases rapidly when the disease recovers, and is not as susceptible to various factors such as erythrocyte nature, hemoglobin concentration, lipid level, and patient age like ESR.