What are the dangers of HGH? What are the side effects of growth hormone

Growth hormone has an anabolic effect, increases muscle, promotes bone growth in childhood and adolescence, and strengthens tendons and enlarges internal organs.

The use of human growth hormone carries a high risk of contracting fatal diseases such as AIDS, and excessive use of growth hormone can reduce insulin sensitivity and cause glucose intolerance. The excessive use of exogenous growth hormone can also cause the human body to produce an antibody response to growth hormone, thereby affecting the activity of endogenous growth hormone and leading to hormone secretion disorders. And the damage it causes is irreversible!

A small number of people will have some adverse reactions when using growth hormone, growth hormone is a peptide protein produced by the human body itself, and the structure of the water agent is consistent with the natural structure, which is not easy to produce antibodies, and the probability of adverse reactions is relatively low.

Studies have found that the hereditary causes of hereditary growth hormone deficiency include GHN gene (17q22-24) defects, autosomal recessive mosaic mutations, incomplete deletion of growth hormone, autosomal dominant growth hormone deletion, X-linked growth hormone deletion, PIT-1 gene mutations, and growth hormone receptor or post-receptor defects caused by autosomal genetic mutations. 5% of growth hormone deficiencies are genetically predisposed.

Growth hormone itself does not have ***, and it is an important substance for human growth and development. But too much and too little can be harmful.

1. Too much harm:

Excess growth hormone causes excessive growth of bones, soft tissues, and internal organs, manifesting as gigantism in adolescents and acromegaly in adults.

Manifestations such as thickening of the skull, wide skull and face, high cheekbones, protruding mandible, sparse teeth and poor bite, enlarged hands and feet, hunched back, roughness, increased hair, pigmentation, hypertrophy of the nasolabial and tongue, hypertrophy of the vocal cords, and low pitch may occur.

2. The harm of too little:

Insufficient secretion of growth hormone leads to stunted physical growth, resulting in short stature and dwarfism.

Its growth is stunted, there is no puberty initiation period, and there is an "old child" premature aging appearance in adulthood; short body, but symmetrically proportioned trunk, limbs, and head; epiphyseal development retardation, bone age below chronological age; Symptoms such as dysplasia of sexual organs, non-development of secondary sexual characteristics.

There is no trivial matter for children to take medication, whether the drug is safe or not, whether there is *** is the most concerned thing for every parent. Is HGH safe? What precautions should parents pay special attention to? Clinical experts have something to say.

Professor, Master's Supervisor, Department of Pediatrics, West China Second Hospital, Sichuan University, Director of Short Stature Research Center, West China Second Hospital, Sichuan University, Wu Kangmin.

Q: Based on your clinical experience, is HGH safe to use? Which is more reassuring?

A: Growth hormone has been clinically used for more than 30 years, and as the national regulatory agency for drugs, the U.S. Food and Drug Administration (FDA) and the China Food and Drug Administration (CFDA) have approved growth hormone for the use of short stature in children, so it is very safe to use under the guidance of professional doctors. It can be said that the growth hormone products that have been marketed are trustworthy, and if there is a safety risk, the relevant departments will never approve their marketing.

But at the same time, parents should also be aware that growth hormone is a prescription drug and must be diagnosed by a clinician before it can be used.

Although the drug is safe, there are many safety risks during the operation because growth hormone requires long-term injections and many parents have no experience in medical care. First of all, parents must follow the guidance of medical staff and choose a syringe suitable for children in their daily injection operations. In addition, due to the rapid change of children's height and weight, the dosage of medication needs to be adjusted frequently, and a drug often needs to be used multiple times, in order to reduce the risk of infection, it is still recommended to choose growth hormone containing added antibacterial ingredients.

Secondly, growth hormone, as a protein drug, has high temperature requirements, and high temperature will not only affect the quality of the drug, but also affect the efficacy and safety. At present, most of the growth hormone drugs used in clinical use need 2-8 storage, and some manufacturers have even achieved the whole process of temperature control and cold chain transportation, of course, there are also individual manufacturers to launch the concept of room temperature storage. But here I would like to remind parents, because many people may not know the definition of room temperature at all, which is 20 25.

For example, in some areas of southern China, the temperature exceeds normal temperature for more than 200 days a year, so the temperature control must not be ignored, so as not to affect the quality of medicine and delay children.

From this point of view, the application of growth hormone drugs ** children's short stature is still very safe, but parents need to pay attention to the following aspects in their daily operations.

Growth hormone is generally an alternative drug used for height problems caused by insufficient hormone points, which belongs to hormone drugs with relatively large side effects, and doctors generally do not give drugs to patients casually! If it is really necessary, it should be used as appropriate. It has an impact on diabetes.

It is recommended to go to the hospital to take a bone age film first to see if the epiphysis is closed. Judging by your age, it's probably closed. It cannot be used after the epiphysis is closed.

The cost of growth hormone is affected by a number of factors, and it can be said that the cost of growth hormone is completely different from person to person. To put it simply, the child's weight at the time of the child, the reasons for the short stature, the child's age and bone age, whether the child is sexually developed, the duration of the child, and the choice of different brands and dosage forms of growth hormone will affect the child's plan, and the corresponding cost will also change.

On the topic of HGH costs, an important point that has to be mentioned is the choice of HGH dosage form. To put it simply, the three more common dosage forms on the market are powder, short-acting water agent and long-acting water agent.

Each of these three dosage forms of growth hormone has its own characteristics and advantages.

The earliest market in China is growth hormone powder, from 98 to the present, clinical application for more than 20 years, more than 300,000 people of the first application proves that it has a very good efficacy and safety, in the past 5 years, the powder has dropped significantly, becoming a growth hormone dosage form that can be used by short children in China.

Compared with powder, the structure of the water agent is more natural and the quality is relatively higher. Some growth hormone water can be injected with a cryptoneedle electronic pen, which is very helpful in reducing the fear of injection and reducing pain in children's hearts.

Long-acting water is a breakthrough in the research and development technology of growth hormone, which only needs to be injected once a week, giving parents and children a new choice.

Eat a balanced diet Children should consume six major groups of nutrients (carbohydrates, lipids, proteins, vitamins, water and inorganic salts) every day, and parents can refer to the daily dietary guidelines to understand the dietary needs of children of different ages. Adolescent children grow faster and are more active, and the need to provide them with the nutrients they need to grow and develop is also higher, with the average boy taking 2150 2650 calories a day and girls 2100 2200 calories.

Teach children the concept of a balanced diet Most of the three meals in modern dual-income families rely on eating out, and many parents will give their children money to buy their own lunches. Dietitians suggest that parents pay more attention to their children's eating out, and tell their children some healthy eating concepts, such as: eat less fried and fried things, choose dishes in a balanced and varied manner, and take in six types of nutrients.

Parents are unable to grasp their children's diet, which can easily lead to poor nutritional status of their children in the long run.

Parents should not be picky Eating habits of children from an early age are most influenced by their parents. If you want your child to grow up well, not being picky is the most basic principle. Parents should try to vary as much as possible when preparing the dishes for their children's meals, so that children can try more foods from an early age.

If you eat a wide variety of foods, you don't have to worry about a lack of nutrients for growth.

Don't ask your child to make negative comments about food For example: "Durian stinks, you eat it too?" A casual remark from an adult will make the child establish a specific impression of a particular food, which will later become an excuse for him to refuse to eat.

Plant growth hormone and animal growth hormone are different. Animal growth hormone is always present in the course of human existence, and it is harmless at normal levels.

All good things are in excess, and it will cause ***. Excess growth hormone will cause the epiphyseal line to close prematurely, and the human body will mature early, resulting in not growing taller.

Growth hormone is a normal hormone in the human body, which plays an important role in the growth and development of the human body and the maintenance of physical strength in adults.

There is a certain amount of growth hormone injection in children, which is manifested in the following aspects:

1. Injection of growth hormone may promote the reproduction of tumor cells and have the risk of inducing tumors;

2. After the injection of growth hormone, some children may have elevated blood sugar and diabetes caused by the application of hormones;

3. After some children are injected with growth hormone, they may experience symptoms such as headache, vomiting, dizziness and increased intracranial pressure.

The incidence of growth hormone caused by the above is relatively low, in general, the injection of growth hormone is small for children, and the indications should be strictly grasped when applying growth hormone to children. If the child has short stature due to growth hormone deficiency, it should be carried out in accordance with the standard dose under the guidance of a doctor**, if the child does not have growth hormone deficiency, do not blindly inject growth hormone by himself, so as not to produce unnecessary ***, causing harm to the child's body.

Growth hormone itself is harmless, for growth hormone for children's growth and development, many parents are worried that it will affect other aspects of their children's health, in fact, growth hormone is not used if you want to use it, you need a complete examination before taking the drug, exclude contraindications to the drug, only meet the conditions of the drug can be used, and in the process of medication, you need to review regularly to ensure the safety and effectiveness of the drug.

Growth hormone is secreted by the human body itself and is harmless to the human body.

Growth hormone has been clinically used for more than 30 years, and it has been confirmed through a number of large-scale statistics that recombinant human growth hormone is still very safe. At present, most of the adverse reactions of growth hormone therapy are short-term transient, mainly including: (1) Headache

It is usually benign and provides significant relief when the drug is stopped, and the drug can be continued after the headache has resolved. (2) Abnormal blood glucose: Children receiving growth hormone** may have abnormal blood sugar or fasting insulin elevation (including insulin resistance and glucose intolerance disorders), but the clinical significance seems to be small, and it is usually transient and can return to normal in a short period of time.

3) Hypothyroidism: Growth hormone may cause the conversion of T4 to T3, so there is a possibility of a slight decrease in blood T4 in the early stage, so thyroid function will be monitored regularly during the use of growth hormone**. (4) Joint edema and pain:

It is very rare for children to receive growth hormone**. Most usually develop soon after treatment is initiated, and some of them may be caused by sodium and water retention. (5) There are also rare conditions, such as idiopathic intracranial hypertension, increased intraocular pressure, slipped epiphysis of the femoral head, and a slightly increased risk of exacerbation of pre-existing scoliosis.

Whether these are adverse effects of growth hormone itself or whether some of them are related to the rapid growth induced by growth hormone is still being studied.

Growth hormone has been used in more than 30 countries around the world for nearly 60 years, and developed countries have included growth hormone as medical insurance.

Under the guidance of your doctor, you can take medication in strict accordance with the doctor's instructions and conduct relevant tests regularly, which can rest assured that the safety of growth hormone is a problem.

Adverse Reactions Supplement:

1) Growth hormone can cause transient hyperglycemia, which usually returns to normal with the prolongation of the drug time or after discontinuation.

2) In clinical experiments, about 1% of children with short stature have ***, common local transient reactions (pain, numbness, redness and swelling, etc.) and fluid retention symptoms (peripheral edema, arthralgia or myalgia) at the injection site, which occur earlier, but the incidence decreases with the time of medication, and rarely affects normal life.

3) Long-term injection of growth hormone will cause antibody production in a small number of patients, and the binding capacity of antibodies is low, and there is no definite clinical significance.

There are no statistics on the effective rate.