How to treat granulomatous cheilitis, granulomatous cheilitis symptoms

Cheilitis is an immune disease of the body, and there seems to be no good solution in Western medicine at present. Traditional Chinese medicine is relatively slow to work, but fortunately, it works, and it is not easy**. One example I know of is my college tutor, a man in his forties.

But our mentor was more easy-going, so he chatted with us often and talked about his condition. After two or three years of cheilitis, I tried various methods during the period, and finally found a Chinese medicine expert in this area, Du Hongyu of the Department of Stomatology of Hefei Changhuai Traditional Chinese Medicine Hospital. After drinking Chinese medicine for several months, the condition is slowly getting better, and now I don't see the ** situation!

I have one on my upper lip, but it is very small, I just had two months to go to the medical university dental hospital for surgery, other methods are useless, now the stitches have been removed for four days, fortunately the scar is not obvious. The cost of surgery plus pathology is a little more than 1,000, and no pathology can save more than 600. But doctors recommend doing it.

There are related manifestations of granulomatous cheilitis, so what are the symptoms of granulomatous cheilitis?

Most of the onset occurs in young or middle-aged people. There was no significant difference between men and women. Onset and progression are slow, and there is usually no history of trauma or local infection.

Both the upper and lower lips can be affected, but the upper lip is more common. Generally, it starts on one side of the lip, and the red lip mucosa is normal. The swelling is soft and has a mattress feeling.

Swelling is characterized by **, no itching, and no pitting edema under pressure. Swelling may resolve completely at the beginning of the disease, but not completely after several times**.

As the disease progresses, it spreads to the entire lip and affects neighbors**. The lip is swollen to 2 to 3 times the usual size, forming a giant lip and appearing a symmetrical longitudinal fissure, corrugated. Exudate may be present in the fissure, and the red area of the lip is purplish-red.

The swelling area is pale red at first, and turns dark red after reverse. In addition to swelling of the lips, swelling can also occur in other parts of the face, such as the cheeks, nose, jaw, periorbital tissues, etc. The mucous membranes of the teeth, tongue, gingiva, and buccal are generally normal.

Regional lymph nodes may be enlarged.

Clofazimine is effective in most people, 100 mg orally twice a day for 10 days, and then twice a week for 4 months. Prednisone 40 to 60 mg daily, temporarily effective, often after discontinuation of the drug**. Surgery** sometimes works well.

Granulomatous cheilitis?

Repeated or chronic swelling and hypertrophy of the lips, eventually a giant lip, hence the name granulomatous (granulomatous).

macrocheilitis）。The reason is unknown. Pathologically granulomatous changes. More difficult.

Clinical manifestations: most common onset in young or middle-aged age. There is usually no trauma and a history of local infection. Rash of one lip followed by involvement of the other lip, with varying intervals.

Sometimes two. The lip is affected at the same time, and there are also patients who have only one lip affected. Early manifestations are sudden, diffuse edema of the lips, similar to angioedema, which can affect the cheeks, even the forehead, scalp, and sometimes fever and mild constitutional symptoms.

Swelling subsides completely at first. Later, the swelling does not completely subside after remission, or the seizure alternates with remission. Normal skin color or slightly reddish, purple, soft and elastic, such as pinched soft rubber.

Sometimes the lips are rough, peeling, dry, and cracked, and sometimes they are moist, oozing, and crusted. Most of the local discomfort, tingling, and pain are felt. The mucous membranes of teeth, tongue, gingiva, and buccal are generally normal.

Regional lymph nodes may be enlarged. Laboratory tests are generally within the normal range.

Pathological changes: the most predominant changes are chronic granulomatous inflammatory cell infiltration, most obvious in the upper dermis, and can extend downward to the deep dermis or even the muscular layer. The infiltrating cells are usually lymphocytes, plasma cells, epithelial and lead-like cells, and sometimes philophiles.

Acidic granulocytes and multinucleated cells. The lymphatic vessels are dilated and sometimes partially occluded.

Diagnosis and differential diagnosis:

Diagnosis is not difficult based on sudden, diffuse, substantial swelling of the lips that does not resolve completely during remission. Differentiating disorders are: angioedema, plasma cell cheilitis, and Ascher syndrome.

Characterised by granulomas of noncaseated epithelial cells, mostly in the lamina propria and submucosa, and sometimes in the glands and muscles. Chronic inflammatory cells such as lymphocytes and plasma cells infiltrate around mucosal glands, blood vessels, and lymphatic vessels, causing collagen swelling, stromal edema, and vasodilation and thickening. Some specimens may have no characteristic granulomas, only interstitial and vascular changes.

Prednisone, cortisone, prednisolone, triamcinolone acetonide, etc. can be used**. Drugs such as clofazimine and metronidazole can be used if the effect of corticosteroids is not good or in order to avoid the *** caused by long-term use of corticosteroids. Clofazimine, the drug may cause mild gastrointestinal reactions, such as nausea, vomiting, diarrhea, itching and other adverse reactions.

About 20% of patients have copper-like pigmentation after the eventual period, which usually disappears after the end. To prevent this, sun exposure should be avoided during the period. Metronidazole, also known as methrin, has adverse reactions such as loss of appetite, nausea, and vomiting.

Occasionally, headaches, insomnia, decreased white blood cells, and difficulty urinating are common. Alcohol should be abstained from while taking the drug.

Minocycline may be used for antibiotics. Surgery can be considered after the formation of a giant lip to repair the shape of the lip, but the rate is high, and other measures must still be taken to prevent it after surgery. It is important to remove the odontogenic stain and tooth-related lesions.

**Unknown. It may be related to bacterial or viral infections such as streptococcus, mycobacteria, and herpes simplex virus, allergic reactions to cobalt, cinnamon, cocoa, celery, etc., vasomotor disorders regulated by the autonomic nervous system, and genetic factors. It has also been reported in the literature that it may be related to chronic apical periapical disease and nasopharyngeal inflammation.

In women, it may be related to the menstrual cycle.