Adverse effects of long acting intravenous insulin use

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Insulin resistance improved in 7 days, blood sugar dropped significantly, and complications improved.

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The biggest adverse reaction is hypoglycemia! Therefore, it is necessary to check blood sugar at the time of injection, and it is generally not recommended for patients to self-inject.

(1) Administration method: regular insulin is injected subcutaneously half an hour before meals, and intermediate-acting or long-acting insulin is often injected subcutaneously 1 hour before breakfast. In an emergency, only regular insulin can be given intravenously.

2) Drug extraction: Insulin injection must be injected using 1ml or a special syringe that matches the insulin concentration content. Note that the dosage of the drug must be accurate, and the commonly used insulin preparations in China have two specifications of 40U or 100U per ml.

Gently shake the drug when suctioning, but avoid shaking violently. When long-acting and short-acting insulin are mixed, short-acting insulin should be aspirated first, then long-acting insulin, and then mixed, and must not be operated retrograde, so as not to mix long-acting insulin into the short-acting insulin and affect its rapid action. (3) Injection site:

Insulin is injected subcutaneously, and it is advisable to choose the most loose parts, such as the deltoid muscle of the upper arm, the gluteus maximus, the front of the thigh, the abdomen, etc., and the injection site should be used alternately to avoid the formation of local induration and lipoatrophy, which affects the absorption and efficacy of the drug. (4) Observation and treatment of adverse reactions: Adverse reactions to insulin include:

Hypoglycemic reactions: are the most predominant adverse reactions and are associated with excessive doses and/or eating disorders. Insulin allergy:

Presents with itching, urticaria-like rash at the injection site, generalized measles is rare, and severe allergic reactions are rare. Subcutaneous fat atrophy or hyperplasia at the injection site can recover slowly and naturally after stopping the injection in the area. For hypoglycemia, blood sugar should be measured in time, and 20-30ml of 50% glucose solution should be eaten according to the condition. For patients with allergic reactions, immediately change the type of insulin preparation, use antihistamines, glucocorticoids and desensitization therapy, etc., and those with severe allergies need to stop or temporarily interrupt insulin**.

5) Drug preservation: Insulin should be stored in the refrigerator (5-15) to avoid heat, light and freezing. If the expiration date has expired or if particles appear in the solution, it cannot be used.

Hope all of the above can help you o( o

Do you really know how to use insulin?

Precautions for the preservation and administration of insulin: 1) Preservation of insulin: It needs to be stored in the refrigerator (about 5 degrees Celsius), and it should be taken out from the refrigerator 1 hour before injection to raise the temperature before use, and the supercooled drug is not easy to absorb after injection, and can cause atrophy of the fat layer 2) Insulin extraction:

It is necessary to use a special syringe that matches the concentration of insulin 1 ml, and the required dose and type should be checked before extraction, determine its concentration and expiration date, and be extracted after full shaking 3) Selection and alternation of injection sites: multiple selection** soft parts for injection.

1. Allergies, mild cases will appear in the injection area, with itching, and disappear after a while; In severe cases, the whole body has a rash and itching is unbearable.

2. Hypoglycemia, which occurs when the injection is excessive or the diet is reduced, is the most common adverse reaction;

3. Weight gain is the result of insulin injection and not controlling diet;

4. Edema of the lower limbs, the initial reaction of insulin injection, disappears after adaptation;

5. Blurred vision, relatively rare, is also a reaction in the early stage of insulin injection, disappearing after adaptation;

6. Subcutaneous induration, which is related to repeated injection in the same part too frequently;

7. Subcutaneous fat atrophy.

1.**Redness, swelling, subcutaneous induration.

2.Hypoglycemic reaction.

3.Drug dependence.

4.Antimicrobial resistance. And so on,

I have four injections a day, three meals are short-acting and Changxiulin at night, and sometimes I still have low blood sugar at night. You're so happy that you only need one shot a day.

I have already used 3 insulin glargine of Changxiulin, and now I take 20 units every night and metformin during the day, but my blood sugar is still not well controlled, and my fasting is between 8-10, do I have to increase the amount of insulin injection? View the original post" Hope.

Clinical application: There must be a hypoglycemia, followed by intravenous infusion with glucose and potassium chloride, which can correct intracellular potassium deficiency, prevent and treat arrhythmia during myocardial infarction and ** energy to facilitate the recovery of heart function (it seems to be called polarization fluid).

Adverse reactions: (1) Hypoglycemic reactions can occur if the dose is too large, manifested by palpitation, sweating, trembling, paleness, chills in the limbs and hunger, and in severe cases, consciousness disorders and coma may occur. Long-term hypoglycemia can cause brain damage.

2) Injection can produce hard lumps. (3) It can cause lipid dystrophy, insulin resistance, allergic reactions, etc. Occasionally, there are allergic reactions such as urticaria, angioedema, and anaphylactic shock.

Pharmacology 27-Insulin: Commonly used insulin preparations, effects and applications, and prone adverse reactions.

1. Insulin injection methods: there are two types, intravenous drip and subcutaneous injection, intravenous drip is used for patients with diabetic ketoacidosis and diabetic hyperosmolar coma. Subcutaneous injection is used in the daily life of all types of diabetic patients**.

The methods were: 1. Ultra-long-acting insulin analogue or intermediate-acting recombinant human insulin injected once a day; 2. Premixed insulin (30R, 50R) is injected twice before breakfast and dinner; 3. Short-acting insulin injection before breakfast and lunch, premixed insulin injection before dinner, three times a day. 4. Four times a day, that is, short-acting insulin injection before three meals, and intermediate-acting insulin injection before bedtime.

Hour-long continuous infusion (insulin pump injection).

2. When the hypoglycemic effect of oral hypoglycemic drugs is poor, it is generally used to inject intermediate-acting insulin or ultra-long-acting insulin analogues 10-12u before bedtime or in the morning, which has a good effect. If insulin replacement is completely used**, 2-4 injections per day are generally used, and the number and amount of injections are determined according to the patient's blood glucose, weight and whether there are complications.

3. Short-acting insulin takes effect 30 minutes after injection, and ultra-short-acting insulin analogues take effect 5 minutes after injection, so short-acting insulin and ultra-short-acting insulin analogues will cause hypoglycemic reaction if they do not eat after injection, which is generally not commonly used.

1. How to use insulin: 1. Intravenous infusion: refers to the intravenous infusion of a small dose of insulin, usually at a rate of intravenous infusion per kilogram of body weight per hour, to lower blood sugar. 2. Subcutaneous injection: There are three types of insulin proprietary syringes, insulin pens and insulin pumps.

2. Precautions for using insulin: 1. Accurate medication: make sure that the preparation and type are correct, the dosage is accurate, and the injection is on time.

2. Inhalation sequence: When long, short-acting or short-acting insulin is mixed, short-acting insulin should be inhaled first, and then long-acting insulin should be aspirated, and then mixed well. 3. Preservation of insulin

Unopened insulin should be kept in the refrigerator at 4-8 degrees Celsius, and the insulin being used can be used for 28 days at room temperature (no more than 28 degrees). 4. Selection of injection site: Insulin is injected subcutaneously, and it is advisable to choose the most loose parts, such as the deltoid muscle of the upper arm, gluteus maximus, the front of the thigh, and the abdomen, and the injection site should be changed frequently.

5. Strict aseptic operation of insulin injection to prevent infection. 6. Pay attention to monitoring blood sugar.

3. Adverse reactions to insulin: 1. Hypoglycemic reactions. 2. Allergic reactions. 3. Subcutaneous fat atrophy or donation at the injection site.

Insulin has long-acting and general, I have been with type 2 diabetes for many years, blood sugar control is not ideal, I was reluctant to use it, and then the kidney function was damaged, and the doctors also had disagreements, and I was afraid of gaining weight, but the drug sugar control was always not ideal, so I started to use long-acting insulin glargine from 4 units, gradually increased to 12 units per day, and took drugs at the same time.

2 long-acting + 3 short-acting, long-acting 8 pm timed, short-acting before each meal; 2 times of medium effect, 1 time of medium effect before breakfast and dinner; 1 long-acting one, in the evening, plus 3 oral medications, 3 before meals. Generally, the high ones are 2 times to play well, the 4 times are very high and difficult to control or type 1, and the 1+3 times medicine is even lower.

2. Your second question is very complicated, because it is necessary to consider the patient's previous medication history, diabetes history, age, if I use it, if the 20mmol l of the initial diagnosis and treatment is after a meal, I will change him to 2 times to play the medium effect, 12u in the morning, 10u in the evening, if there is a history of drugs, the dosage should be increased according to the drugs used, if it is 20 on an empty stomach, I will recommend playing 1+3, and 18u of glargine at night 8-12 before three meals, and look at postprandial blood sugar.

3. I haven't met a patient who wants to be beaten like this, and ketosis is not beaten like this, and question 3 will not.

4. If you encounter high ketosis at night, give an NS 250+ insulin of about 14U intravenous drip is good, and one bottle can't drop 2 bottles.

Do you really know how to use insulin?