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Antihypertensive drugs are most effective when taken half an hour to 1 hour before the blood pressure reaches its highest value. It can be seen that the best time to take antihypertensive drugs is 8:30 a.m. and 2:30 p.m., so that the drugs coincide with the peak of blood pressure to control the increase in blood pressure.
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A reasonable time to take the drug should take into account the circadian biorhythm of human blood pressure. Normally, when you wake up in the morning, your blood pressure will continue to rise, peaking at 9-11 a.m. Therefore, it should be taken early in the morning after waking up and brushing your teeth, rather than waiting until after breakfast or later.
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As night falls, blood pressure decreases, and after falling asleep, it continues to decline, with blood pressure lowest at 2-3 a.m. Antihypertensive drugs should not be taken at bedtime or later. Therefore, it is generally necessary to take medicine after waking up in the morning.
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According to the change in blood pressure, antihypertensive drugs (including controlled-release tablets and extended-release tablets) taken once a day are usually taken at 7:00 in the morning. Take antihypertensive medicine twice a day, preferably at 7:00 a.m. and 2:00 p.m.
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Some people with high blood pressure also need to take aspirin. Most people take aspirin once a day, in the morning or evening, and it is best to take it at the same time every day. If it is an ordinary aspirin tablet, it can be used before or after meals, depending on whether the gastrointestinal tract is good or not.
If the gastrointestinal reaction is greater when you take medicine half an hour before a meal, take it half an hour after a meal.
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Take the medicine immediately after waking up in the morning on an empty stomach. Because taking it on an empty stomach is faster than taking it after a meal, but some patients will also take it with food to delay absorption in order to avoid hypotension caused by taking it on an empty stomach, and the overall antihypertensive effect will not be significantly affected.
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In addition to diuretics, long-acting antihypertensive drugs can be taken at bedtime, and it is better to take sartan or pril antihypertensive drugs at bedtime, and can also prevent the development of new-onset diabetes.
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The oral absorption of short-acting captopril is affected by food, and it has been reported that it can absorb 60% to 75% when taken on an empty stomach, and only 30% to 40% when taken after meals, so it is recommended to take it 1 hour before meals.
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Oral absorption of hydrochlorothiazide is rapid, but incomplete, and eating can increase absorption, which may be related to increased retention time in the gastrointestinal tract. Indapamide (shoubishan, sodium induce) is recommended to be taken half an hour after a meal.
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The best time is when the heart muscle can still pump blood strongly, and the power to pump blood has weakened. That's the best time
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