Will I become resistant to the same antihypertensive drug for a long time?

Long-term consumption of the same antihypertensive drug will definitely cause this kind of drug resistance, and if you eat it regularly, it will cause this burden on the kidneys, and this indicator of the body will be very dangerous, so you must pay attention to it.

There is a high possibility of drug resistance, so it is recommended to go to the hospital for a re-examination after taking the drug for a period of time and take another medicine.

If you feel that you can't control your blood pressure well by taking medicine, it is often due to taking drugs or foods that raise blood pressure, or it may be due to the pressure of your living environment.

There is no need to worry about drug resistance when taking antihypertensive drugs for a long time, after all, not taking drugs will cause more harm to the body, and only by controlling your blood pressure within a reasonable range can your body benefit.

Rumors

Antihypertensive drugs need to be changed regularly, and taking one medicine all the time can lead to drug resistance.

Debunking rumors

As a chronic non-communicable disease, hypertension has a high prevalence and disability rate, which has caused a heavy burden on families and society, and seriously consumed medical and social resources. Patients with high blood pressure should lower their blood pressure through lifestyle interventions and medications. Lifestyle interventions include the promotion of a healthy lifestyle and the elimination of behaviors and habits that are detrimental to physical and mental health, throughout the entire process.

On the basis of lifestyle modifications, antihypertensive drugs are selected and individualized according to blood pressure levels and cardiovascular risk**. Once hypertension is diagnosed, it needs to be adhered to for a long time**. Some patients who have been taking antihypertensive drugs for a period of time are worried about developing resistance and ask for a change in antihypertensive drugs.

So, can taking the same blood pressure medication all the time develop drug resistance?

In general, microorganisms, parasites, and tumor cells become resistant to drugs. Most commonly when antimicrobial drugs kill or inhibit bacteria, in order to strengthen their defense ability, various microorganisms resist the attack of antibacterial drugs by changing their own metabolic pathways or producing corresponding inactivated substances, so that the sensitivity of microorganisms to antimicrobial drugs is reduced or even disappeared. But hypertension is neither a microorganism, nor a parasite, nor a tumor, so it is not drug resistance.

Some patients take antihypertensive drugs, their blood pressure fluctuates, does not meet the standard, and the effect is not good, and they think that they have developed drug resistance. This is not the case, blood pressure is affected by many factors. A person's blood pressure fluctuates, is not static, and may be different every 1 hour in 24 hours.

In hypertensive patients, blood pressure is unstable, and other reasons need to be considered in addition to drug factors. For example, whether lifestyle adjustments have been made, whether salt intake has been reduced, whether appropriate exercise, regular work and rest and good mood are maintained every day, whether other risk factors such as dyslipidemia, high blood sugar, high uric acid, etc., and with age, the degree of arteriosclerosis increases, and many people's blood pressure will also change.

It can be seen that the patient's blood pressure is not well controlled after taking antihypertensive drugs, not because of drug resistance. If the oral drug has a good effect and there is no obvious ***, it can be taken for a long time and regularly, and there is no need to change or stop the antihypertensive drug on a regular basis. Regular drug changes may cause blood pressure fluctuations, which is not good for the condition and can easily lead to adverse events such as heart, brain, kidney and other organ damage.

Rumor refutation expert: Bian Yuan, deputy chief pharmacist of the Department of Pharmacy of Sichuan Provincial People's Hospital.

Review expert: Tong Rongsheng, director and chief pharmacist of the Department of Pharmacy of Sichuan Provincial People's Hospital.

Producer: Popular Science China - Science Refutes Rumors.

Some patients with high blood pressure will be a little suspicious when taking drugs, and will think that long-term use of a blood pressure drug will develop drug resistance, and the drug will not have the effect it should have in the process of taking the medicine. In fact, this kind of thinking is wrong, when taking antihypertensive drugs, drug resistance will not be generated, as long as the antihypertensive drugs prescribed by the doctor are obtained, the blood pressure of patients with hypertension will be effectively controlled. Drug resistance mainly refers to the reduction of the efficacy of the drug to the human body, simply put, the effect of the drug will be weakened, and the acquired drug tolerance mainly refers to the reduction of the body's response to the drug after taking the drug for a long time.

However, if the antihypertensive drugs taken by hypertensive patients for a long time have a good effect and no adverse reactions, they do not need to change the drugs.

What are the possible benefits of taking blood pressure medication for a long time?

The advantage of taking antihypertensive drugs is that it brings stable control of blood pressure, which does not cause drugs and complications, and will also cause too much harm to the patient's life. Therefore, for patients, when taking drugs, they must strictly follow the doctor's instructions to take drugs, do not choose the type of antihypertensive drugs without authorization, and take them on time, and do not stop taking drugs at will. At the same time, you should monitor your blood pressure at home, understand your physical condition, and seek medical attention in time if there is any abnormality.

At the same time, it is necessary to do a good job in life intervention, focusing on light diet and appropriate exercise.

What kind of bad results can be produced by taking blood pressure medication for a long time.

Long-term use of antihypertensive drugs may cause some bad results, which is also more common in life, and may cause some drugs, such as bradycardia, headache, facial flushing, edema, dry cough, nausea, dizziness and vomiting, and some drugs may also cause liver and kidney damage. It may also cause some complications, such as coronary heart disease, myocardial infarction, arrhythmia, cerebral hemorrhage, cerebral infarction, etc.

Finally, there is no need for patients to worry, taking a drug for a long time will develop drug resistance, and some people do not have a good effect after taking the drug, which may be caused by the condition, so for this situation, it is necessary to adjust the antihypertensive regimen.

Long-term use of antihypertensive drugs does not produce drug resistance, as long as you take it according to your doctor's instructions, even if you take it for a long time, the effect will still be very good.

Long-term use of antihypertensive drugs will not develop drug resistance, as long as you take it according to the doctor's instructions, you do not have to worry even if you take it for a long time.

Many hypertensive patients ask: Will hypertensive patients develop drug resistance if they take antihypertensive drugs for a long time? Patients with hypertension must insist on taking antihypertensive drugs for a long time, daily, monthly, and every year, and cannot stop taking them at will.

Since it is necessary to take it for a long time, experts and scholars who study antihypertensive drugs have long considered whether long-term use of antihypertensive drugs will cause drug resistance. The antihypertensive drugs on the market have been scientifically studied, and if they are resistant to drugs after long-term use, the antihypertensive drugs cannot be marketed, and the national drug review and supervision department will not approve it.

Some patients start taking a blood pressure medication and their blood pressure is normal, but after a year or two, their blood pressure rises, not because of drug resistance, but because the patient's condition has changed. There are many factors, such as the obvious change of the seasons in some places, blood pressure decreases in the summer when the temperature is hot, and increases in the cold in the winter. Therefore, the type and dose of antihypertensive drugs should be adjusted according to the blood pressure level.

The best principles for the use of antihypertensive drugs:

1.Start with the lowest effective dose to reduce the occurrence of adverse reactions. If blood pressure is effective but blood pressure control is still not ideal, the dose can be gradually increased as appropriate to obtain the best results.

2.A once-daily, 24-hour long-acting formulation is recommended to ensure stable blood pressure lowering 24 hours a day.

3.When the efficacy of a single drug is not good, it is not advisable to increase the dose of a single drug too much, but to use a combination of two or more drugs as soon as possible**.

4.When determining whether one or more antihypertensive drugs are effective and whether changes are needed, the time required for the drug to achieve maximum efficacy should be fully considered. It is not reasonable to change the regimen too often before the drug has its maximum effect.

There are often such patients in hypertension clinics, especially middle-aged and elderly patients, who complain that they have a good effect when they first start taking antihypertensive drugs, and only take one antihypertensive drug, and the dose is not large, z[+@4, Baimu Medicine.

Antihypertensive drugs generally do not develop resistance. This is certain. Because antihypertensive drugs are not like antimicrobials, they must be taken for a long time or even for life, and if drug resistance is to develop, this antihypertensive drug cannot be marketed.

z[+@4, Baimu Pharmaceutical.

Some patients do not have a satisfactory antihypertensive effect after 2 to 3 years of starting to take a blood pressure medication, and this situation may be due to a change in the patient's condition. It is very common for a person who did not have high blood pressure two years ago and now has high blood pressure; It used to be high blood pressure, but now that I am getting older, high blood pressure is heavier and more complicated than before, which is also a very common phenomenon; There are also some patients who suffer from other diseases at the same time and take some other drugs at the same time, and these drugs may interfere with the effect of antihypertensive drugs, and some may also raise blood pressure, such as cold medicines, which will reduce the antihypertensive effect of some antihypertensive drugs; In addition, some patients are taking health supplements or supplements, which will also affect or interfere with the effect of antihypertensive drugs; Weight gain can also raise blood pressure by ......So, there are many factors that affect blood pressure. If you find that your blood pressure medication is not working, you must see your doctor.

Different measures should be taken to adjust antihypertensive drugs for different causes.

z[+@4, Baimu Pharmaceutical.

The author has a special needs outpatient clinic every Tuesday afternoon).

z[+@4, Baimu Pharmaceutical.

At present, international experts and scholars have reached a consensus that most patients with hypertension need to take two or more antihypertensive drugs to reduce blood pressure to normal levels. A single antihypertensive drug often fails to achieve blood pressure.

Will I be resistant to taking a blood pressure medication for a long time?