What causes vasculitis?

1. Smoking. Smokers account for 60-95% of patients with Buerger's disease. Clinical observation has found that smoking cessation can improve the condition of patients with Buerger's disease, and relapse smoking can worsen the condition.

However, the incidence of Buerger's disease in smokers is still a minority, and some patients with Buerger's disease have no smoking history. Thus, smoking may be an important factor in the development of Buerger's disease, but it is not the only one**.

2. Heredity. 1 5% of patients with Buerger's disease have a family history. Many scholars have found that some specific sites of human leukocyte antigen (HLA) are associated with the pathogenesis of Buerger's disease.

3. Hormonal disorders. The vast majority of patients with Buerger's disease are male (80-90%), and the onset of the disease occurs in young adulthood. It has been suggested that prostate dysfunction or excessive loss of prostatic fluid can reduce prostaglandins, which have the effect of dilating blood vessels and inhibiting platelet aggregation, and may cause peripheral vasomotor dysfunction and thrombosis, resulting in this disease.

The first of vasculitis is smoking, smoking is the main culprit of a variety of peripheral vascular diseases, affected by cold and dampness, malnutrition, and infection can cause vasculitis.

Buerger's disease is also known as disease. It usually occurs in young and middle-aged men, and most of them have a history of severe tobacco addiction. Typical clinical manifestations include intermittent claudication, pain at rest, and migratory superficial thrombophlebitis.

The disease mainly invades the limbs, especially the middle and small arteries of the lower limbs and their accompanying veins and superficial veins, the affected blood vessels present full-thickness non-purulent inflammation of the vascular wall, there is thrombosis in the lumen, and the lumen presents progressive stenosis and even complete occlusion, causing limb ischemia and pain, and in severe cases, ulcers and gangrene that are not easy to heal can occur at the extremities. **It is not clear at this time. It can lead to permanent dysfunction or limb loss, or even death.

The best principle of Buerger's disease is to prevent the development of lesions, improve blood supply to the affected limb, reduce pain in the affected limb, and promote ulcer healing.

Vasculitis, also known as thromboangiitis obliterans, occurs more often in young adults, more in men than in women, and smokers have a higher incidence rate. Vasculitis is a serious disease caused by vascular occlusion caused by intravascular thrombosis in the arteries, resulting in avascular necrosis of the corresponding limbs.

The initial clinical manifestations of vasculitis are the appearance of pale cyanosis of the ischemic limbs, and redness when sagging. Most patients have pain when walking, also called intermittent claudication, and rest to relieve the pain after walking for a while, sometimes accompanied by superficial phlebitis migrans, and eventually severe pain, rest pain, acral necrosis, and eventually continuous amputation.

Vasculitis is the infiltration of autoinflammatory cells in and around the blood vessel wall, accompanied by vascular damage, including cellulose deposition, collagen fibrillar degeneration, endothelial cell and muscle cell necrosis, also known as vasculitis. Primary vasculitis is caused by direct action on the blood vessel wall, and vasculitis is caused by certain clinical signs and symptoms on the basis of vascular inflammation; Secondary vasculitis is caused by inflammatory lesions in adjacent tissues that spread to the blood vessel wall.

It is thought to be due to occlusion due to arteriolar spasm and thrombosis, resulting in ischemia. Half of them are associated with Raynaud's phenomenon, and are more common in men, with smokers being the majority. Smoking is closely related to the course and prognosis of the disease.

The disease is more common in young adults and is more common in the lower limbs. The affected limb presents temporary or persistent pallor, cyanosis, burning and tingling pain, the skin color of the affected limb becomes red when it hangs, it becomes white when lifted, followed by numbness of the toes, pain in the calf muscles, irritation when walking, and disappearance at rest; Superficial phlebitis and edema often occur in the lower legs. On examination, dorsalis pedis pulse is diminished or absent.

As the disease progresses, intermittent claudication and Raynaud's phenomenon may occur, pain worsens at night, and pain in the toes is severe, cyanosis, and then ulceration or gangrene at the end of the toes and blackening, which gradually spreads to the proximal end.

Vasculitis is medically known as thromboangiitis obliterans, he is more likely to occur in young and middle-aged men, more accumulation of limbs, is a kind of arterial disease that does not understand the cause of small and medium-sized arteriolatic lesions until vascular stenosis or even occlusion, it is generally believed to be related to cold, dampness, smoking, sex hormones, autoimmunity, etc., in the early stage, the patient's limbs are numb, sore, cold, intermittent claudication, this stage is easy to be confused with the lumbar intervertebral disc close to the sciatic nerve, and in severe cases, the intermittent distance can be shortened, the pain is aggravated, and the patient can not sleep at all, The dorsalis pedis artery and the posterior tibial artery disappear, so that the ulcer is very easy to occur, and it is not easy to heal after ulceration, and there is the possibility of amputation.

For specific details, you can go to "Xijing Traditional Chinese Medicine Hospital" to see!

The typical symptoms of vasculitis are as follows, you can compare them and see how many of them you have, so that you can make a more accurate diagnosis and seek medical attention.

1.Pain: In the early stage, the patient feels soreness and pain in the calf or soles when walking a certain distance at a certain speed, and is forced to rest or walk slowly to relieve it. In the later stages, persistent pain, especially at night, develops resting pain, often causing the patient to sit with his knees crossed.

2.Chills and paresthesias: the affected limb is cold, sensitive to cold, and sensitive to cold, especially at the tips of the fingers. Because the nerve endings are slightly affected by ischemia, the affected limb may have abnormal sensations such as pain, pins and needles, numbness, and burning.

3.**Color change: abnormal pale skin color due to arterial ischemia, due to decreased superficial venous tone, ** flushing or bruising may also occur on the basis of pallor, and it is more obvious when the limbs are drooping.

4. Weakened or disappeared arterial pulse: With the continuous development of the disease, the pulse of the dorsum of the foot and the posterior tibial artery disappeared or weakened, and at the same time, it was dry and ruptured, the sweat stopped, there was no hair, the nails were thickened and deformed, and nutritional disorders such as paronychia were formed.

5.Gangrene and ulcers: If the later stage of vasculitis is not timely, coupled with mistreatment, trauma, hot compress, etc., it is easy to form ulcers and dry necrosis.

6. Red nodules: about 50% of patients have recurrent migratory superficial thrombophlebitis in the superficial veins of the lower leg or foot before and during the onset of the disease, which is manifested as a red cord nodule, accompanied by mild pain, and after 2-3 weeks of acute attack, the symptoms subside, and the pigmentation is left after subsidence, which heals in one place and rises again in another.

Vasculitis is a rare chronic segmental inflammatory disease of arterioles and veins, and is more common in the lower limbs. Presents with ischemia, pain, intermittent claudication, decreased or absent dorsalis pedis pulse, migratory superficial phlebitis, and in severe cases, acral ulceration and necrosis.

What are the symptoms of vasculitis?

Initial stage: numbness, coldness, sensitivity to cold, heaviness, pin-like pain in the toes, spasmodic pain in the calf muscles, intermittent claudication, weak or absent arterial pulses in the affected limb, migratory superficial phlebitis, and no significant systemic symptoms.

Medium-stage: numbness, chills, cold intolerance, worsening of intermittent claudication, and pain at rest. The affected limb is often flushed, purplish red or pale, the foot is dry, peeling, the toenail grows slowly, thickens and deforms, the hair falls out, the calf muscles are atrophied, and the arterial pulse of the affected limb disappears.

There may be emotional restlessness, dizziness, low back pain, and weakness of muscles and bones.

Late-stage: ulceration or necrosis of the affected limb due to severe circulatory disorders, most of which are confined to the toes or feet, and rarely spread upward to the ankles or calves. The pain is severe and unbearable, and the patient often sits with his knees crossed, beats his chest and feet, screams, and is in pain.

After the toe of gangrene falls off, it often leaves an ulcer that does not heal for a long time. The whole body is often accompanied by fever, dry mouth, loss of appetite, insomnia, constipation, yellow urine and other symptoms.

If it is not ** in the early stage, it is a serious disease.

Vasculitis is a chronic vascular occlusive inflammation, ** is not very clear, the main clinical manifestations are limb cold intolerance, low temperature, **pale, pain, intermittent claudication, rest pain, advanced vascular stenosis or even occlusion, limb ischemia and necrosis, the consequences are serious, so it is necessary to ** as soon as possible, ** methods include, dilation of blood vessels, inhibition of platelet aggregation, anti-inflammatory, traditional Chinese medicine blood circulation and blood stasis, surgery, etc.

Vasculitis is a more serious disease, this disease mainly appears in the patient's legs, after the disease will make the patient appear ischemia, pain, intermittent claudication, dorsalis pedis artery pulse weakened or disappeared and migratory superficial phlebitis, vasculitis disease is best carried out as soon as possible**, if not timely**, when the condition is aggravated, it will even lead to the patient's extremity ulceration and necrosis.

There are many causes of vasculitis, such as smoking, infection, environment, immunity, atherosclerosis, hypertension, hyperglycemia, hyperlipidemia, etc., vasculitis has many harms, if not treated in time, it may lead to necrosis, gangrene, weakened or disappeared arterial pulse, limb pain, decreased skin temperature, etc.

Vasculitis can be considered to be given drugs such as blood circulation and blood stasis, circulation, nerve nutrition, antiplatelet aggregation, anticoagulation, intervention, surgery**.

Vasculitis actually refers to the inflammation of blood vessels, generally including arterial vasculitis, but also venous vasculitis, mainly venous vasculitis, vasculitis belongs to the general term of peripheral vascular diseases, mainly including thromboangiitis obliterans, arteriosclerosis occlusion, deep phlebitis, superficial phlebitis, venous valve insufficiency, varicose veins, diabetic foot, erysipelas, Takayasu's arteritis and other diseases. There are many causes of this disease, mainly smoking, cold, dampness, hormonal disorders, thrombosis and infection. The most important clinical manifestations of patients are pain and ulceration.

Of course, it's serious, no** it needs to be amputated, you can go to Beijing Xijing Hospital to ask about the specific steps.