What is the difference between clotting and clotting of blood

First, the reference is different.

1. Blood agglutination: When some heterotypic blood in the human body meets, the serum condensin in the blood of one party will cause the corresponding condensation on the surface of the blood cells in the blood of the other party to have an immune response.

2. Blood coagulation: the process by which blood changes from a flowing liquid state to a jelly-like clot that cannot flow.

Second, the main body of the reaction is different.

1. Blood agglutination: It is the serum immune response that may occur when blood of different blood types meet.

2. Blood coagulation: It is the enzymatic reaction of a person's blood under the action of coagulation factors in one's own blood.

Third, the principle is different.

1. Blood agglutination: When the human blood vessel is ruptured or the blood encounters a rough surface, the coagulation mechanism in the blood is activated, and the platelets and fibrin in the serum coagulate together on the wound surface to prevent the blood from continuing to flow out. If the body lacks platelets or a clotting factor, the blood will not clot.

2. Blood coagulation: fibrinogen in plasma is transformed into insoluble fibrin. The multimeric fibrin is intertwined into a web that traps many blood cells to form blood clots.

1 2 hours after the blood clotting process, the blood clot undergoes contraction under the action of platelets and precipitates a yellowish liquid.

Clotting is the phenomenon in which red blood cells clot together when two different pieces of blood are mixed together. Coagulation, on the other hand, refers to the conversion of fibrinogen in the plasma into fibrin, which traps red blood cells together to form a blood clot surrounded by serum.

Question 1: What are the factors that affect blood clotting? Coagulation process.

1.Three stages (1) prothrombin activator production.

2) Prothrombin is activated to produce thrombin.

3) Fibrinogen produces fibrin under the action of thrombin.

Two pathways: (1) Endogenous coagulation pathway All coagulation factors involved in blood clotting are intravascular. The initiator factor is XII, and the factors XA, V, CA2+, and PF3 together constitute the prothrombin activator.

2) Exogenous coagulation pathway The initiating factor involved in coagulation is tissue factor ( ) from tissue. The initiating factor is , factor , and Ca2+ form a complex, activating factor X, and the subsequent reaction process is the same as the endogenous coagulation pathway.

Factors that affect blood clotting.

1.General factors (1) Smoothness of the contact surface: The contact roughness accelerates the clotting of blood.

2) Temperature: The temperature rises within a certain range to accelerate blood clotting.

3) Ca2+ concentration: the higher the concentration, the faster the blood clotting.

Question 2: The process and influencing factors of blood clotting in physiology Definition:

Blood clotting refers to the process by which blood changes from a liquid state that flows to a gel state that cannot flow, and its essence is soluble fiber in plasma.

The process of blood clotting:

formation of prothrombin activators;

Prothrombin activators convert prothrombin into active thrombin with the participation of calcium ions;

Soluble fibrinogen is converted into insoluble fibrin by the action of thrombin.

Factors affecting blood coagulation: (1) Smoothness of the contact surface: The contact rough surface accelerates the clotting of blood.

2) Temperature: The temperature rises within a certain range to accelerate blood clotting. (3) Ca2+ concentration:

As the concentration increases, the blood clotting rate increases.

Question 3: Factors affecting blood clotting Why does heparin not coagulate Heparin is an anticoagulant, and its anticoagulation mechanisms include:

1) Enhance the affinity between antithrombin 3 and thrombin and accelerate the inactivation of thrombin;

2) inhibition of platelet adhesion and aggregation;

3) Enhance the activity of protein C, * Vascular endothelial cells release anticoagulant substances and fibrinolytic substances.

1. Different properties: blood agglutination reaction refers to the fact that when some abnormal blood in the human body meets, the serum coagglutinin in the blood of one party will cause blood cells in the blood of the other party.

The corresponding condensator on the surface undergoes an immune response.

Blood clotting and solids are the process by which a liquid state changes from a flowing liquid state to a jelly-like clot that cannot flow.

2. Different reactions: blood agglutination reaction is a phenomenon of serum immunity. The key process of blood clotting is fibrin in plasma.

Transforms into insoluble fibrin.

3. Different functions: blood agglutination When the human blood vessels are ruptured or the blood encounters rough surfaces, the coagulation mechanism in the blood is activated, platelets.

The fibrin in the serum coagulates together on the wound surface and prevents blood from flowing out. Blood clotting is vertebrate.

When bleeding, the blood can coagulate into a clot called a blood cake, which plays a role in stopping bleeding.

Blood coagulation is the process by which blood changes from a liquid state to a non-flowing gel state, and is an important part of the physiological hemostasis process. The coagulation process is generally divided into endogenous and exogenous coagulation pathways. The main difference between the two clotting pathways is that the way they are initiated and the clotting factors they participate in are not identical.

The exogenous coagulation pathway refers to the origin of the clotting of FIII from the tissue.

The FIII molecule binds to FVII in plasma, thereby activating FX. The endogenous coagulation pathway refers to the fact that all the factors involved in coagulation come from the blood, and this process begins with the activation of FXII, FXI, FIX, and FX when the blood comes into contact with the surface of a foreign body with a negatively charged nucleus.

The coagulation process after FX activation is a common pathway, which mainly includes the formation of XA-CA2+-V-complex (prothrombin activator) on the surface of the platelet phospholipid membrane, the activation of prothrombin and the formation of fibrin multimers, and the formation of strong clots under the action of platelets to complete the coagulation process.

Blood coagulation is the process by which blood changes from a flowing liquid state to a jelly-like clot that cannot flow, which is a process of limited hydrolysis of a series of proteins involving clotting factors Blood coagulation consists of three basic steps: the production of thrombogenase complexes; activation of prothrombin; Fibrin production. Thromboplastin complexes are produced through the endogenous coagulation pathway.

The blood changes from a flowing liquid to a jelly-like clot. Blood clotting often occurs when bleeding from trauma or when the lining of blood vessels is damaged, and is a self-protective mechanism of the body. Blood clotting is a very complex process of chemical change, and it is currently thought that the coagulation process consists of at least three basic biochemical reactions:

formation of prothrombin activators; Prothrombin activators convert prothrombin into active thrombin with the participation of calcium ions; Soluble fibrinogen is converted into insoluble fibrin by the action of thrombin.

Platelets clot into a blood crust and water is lost.

If the concentration of coagulation factors decreases or the specificity decreases, blood clotting obstruction will occur, which can easily cause bleeding. For example, in hemophilia patients, because of the lack of coagulation factors, patients have bleeding from subcutaneous tissues and bone joints since childhood.

In addition, the use of anticoagulants can also cause blood clotting processes, such as taking warfarin, heparin, etc., which affect blood clotting, and are common anticoagulants in clinical medicine to treat or prevent the production of various thrombotic diseases.

The cause of blood clotting is the lack of calcium, prothrombin – the active thrombin that requires calcium to activate.