What causes indirect bilirubin to be often high

Hello, I am a doctor in the Department of Oncology of Shijiazhuang Ping'an Hospital.

Most of the bilirubin in the body comes from hemoglobin released by the lysis of senescent red blood cells, including indirect bilirubin and direct bilirubin. Indirect bilirubin is transported through the bloodstream to the liver, where direct bilirubin is produced through the action of hepatocytes. Elevated bilirubin is seen in:

1) Liver diseases: acute jaundice hepatitis, acute yellow liver necrosis, chronic active hepatitis, liver cirrhosis, etc.

2) Extrahepatic diseases: hemolytic jaundice, blood transfusion reaction with blood group incompatibility, neonatal jaundice, cholelithiasis, liver cancer, pancreatic head cancer, etc.

Therefore, you should actively look for the cause of your current high bilirubin before further treatment. If it is convenient, you can go to the hospital for a check-up and consider a specialist test.

As the saying goes: three points rule, seven points nourishment. Therefore, it is necessary to arrange the diet reasonably, live a regular life, be happy in spirit, pay attention to the combination of movement and static, and do not go to the doctor to abuse drugs when you are sick. Please note the following:

1. The diet should be light, such as soy products, fish, vegetables, fruits, etc., containing a large amount of vitamins A, B, C, E, with good antioxidant function and easy digestion and absorption.

2. It is advisable to eat more seafood, shiitake mushrooms, sesame seeds, walnuts, jujubes, lean meat and animal liver and other foods.

3. Avoid drinking alcohol and too many sweets.

4. It is advisable to rest in bed for 1-2 hours after meals to ensure that the liver gets sufficient blood**, which is conducive to liver cell repair.

Suggestion: Hello, direct bilirubin elevation is more harmful, indirect bilirubin elevation is not too big, your indirect bilirubin is not very high, not necessarily caused by liver disease, liver disease is mostly caused by direct bilirubin elevation, which may be related to physical fitness, there is a jaundice called constitutional jaundice, which is an increase in interbladder gallbladder. It's not necessary.

So don't worry too much, it's not a big problem, regular check-ups will do. Good luck soon**.

Bilirubin refers to the items in the liver function test, if the bilirubin is high or low, it indicates that the body is not healthy, and there is an indirect bilirubin in bilirubin, which is high or low It also represents a problem with the body, why is the phenomenon of indirect bilirubin high?

1. Some malignant diseases of the liver will also lead to high indirect bilirubin in the blood. Such as acute jaundice hepatitis, acute yellow liver necrosis, chronic active hepatitis, liver cirrhosis, etc.

2. Hemolytic anemia destroys a large number of red blood cells in the human body, releasing indirect bilirubin, when there is too much indirect bilirubin in the blood, it exceeds the transformation ability of the liver, so that the indirect bilirubin is retained in the blood, thus causing the indirect bilirubin in the blood to be high, this situation is also called hemolytic jaundice, and the patient usually has the symptoms of yellowing, sclera yellowing, and urine yellowing.

3. Blood type incompatibility blood transfusionWhen blood is transfused, it will lead to hemolysis, which will cause a large number of red blood cells in the body to be destroyed, resulting in high indirect bilirubin in the blood.

4. Hepatocellular jaundiceWhen hepatocytes are diseased, or because bilirubin cannot be converted into bile normally, or because hepatocytes are swollen, the bile ducts in the liver are compressed, the excretion of bile is blocked, and the bilirubin in the blood is increased.

5. Neonatal jaundice When the newborn is born, jaundice occurs 48-72 hours (jaundice does not appear in the order of the face, top, trunk and limbs), the spirit is not good, and it does not subside within 2 weeks, which is mainly caused by the mother-child blood type or the congenital biliary malformation of the newborn, which will also lead to high indirect bilirubin in the blood.

Knowing the cause of high indirect bilirubin can help everyone to take precautions at ordinary times. If the indirect bilirubin is found to be high through examination, it should be prompted**.

1. Elevated total bilirubin and increased indirect bilirubin: When suffering from hemolytic jaundice, a large number of red blood cells are destroyed, and indirect bilirubin increases, which exceeds the conversion ability of the liver, so that indirect bilirubin is retained in the blood, thereby causing an increase in total bilirubin. It is generally common in hemolytic jaundice, blood transfusion reactions with blood group incompatibility, neonatal jaundice and other diseases.

2. Elevated total bilirubin and increased direct bilirubin: If there is a problem with the biliary tract, direct bilirubin cannot be fully discharged into the intestine, but reverses into the blood, resulting in an increase in direct bilirubin in the serum, and a high total erythrin will increase, resulting in terrier-negative jaundice. Elevated total bilirubin due to these causes is common in biliary tract diseases such as cholecystitis and cholelithiasis.

3. Total bilirubin is elevated, both direct and indirect bilirubin are elevated: if there is a problem with the liver, that is, the liver cells are damaged, the liver's ability to convert indirect bilirubin into direct bilirubin decreases, which will cause the phenomenon that direct bilirubin and indirect bilirubin are high at the same time, and the total bilirubin is also high, that is, hepatocellular jaundice. When there are liver diseases such as acute jaundice hepatitis, acute yellow liver necrosis, chronic active hepatitis, and cirrhosis, it will cause an increase in total bilirubin.

Extended Information] Total bilirubin (TBIL) is the sum of direct bilirubin and indirect bilirubin. Indirect bilirubin refers to bilirubin that does not bind to glucuronic acid. Indirect bilirubin is poorly soluble in water and cannot be excreted in urine through the kidneys.

Indirect bilirubin is converted within hepatocytes and combines with glucuronic acid to form direct bilirubin (conjugated bilirubin). Direct bilirubin is soluble in water and can be excreted in urine through the kidneys. The liver plays an important role in the metabolism of bilirubin, including the uptake, binding and excretion of unconjugated bilirubin in the blood by hepatocytes.

Clinical significance: The determination of serum total bilirubin is an important test item in liver and biliary function tests. It can accurately reflect the degree of jaundice and is of great significance for the clinical diagnosis of occult jaundice.

1.Physiological elevation: Physiological jaundice occurs in newborns, but there is no other discomfort, and it will resolve spontaneously after about a week.

Long-term alcohol consumption and strenuous exercise may also cause an increase in total bilirubin. High total bilirubin due to physiologic causes usually resolves spontaneously after regulation.

2.Pathological elevation: common in hepatitis, obstructive jaundice, liver cirrhosis, neonatal pathological jaundice, cholelithiasis, pancreatic head cancer, hemolytic jaundice and other diseases.

Patients should pay great attention to it, go to the hospital in time, seize the best opportunity, grasp the development trend of the disease, detect the development and changes of the disease, and have a comprehensive understanding of their own condition.

Question 1: What is the cause of high indirect bilirubin? If you want to know what is high in indirect erythrophilin, let's first understand what indirect erythrophilin is.

Indirect bilirubin, abbreviated as ibil, is mainly caused by the destruction of red blood cells and is not glucuronidated in the liver. Indirect bilirubin is metabolized by the liver and can be changed to direct bilirubin, which is excreted into the biliary tract with bile and finally excreted through the stool. If indirect bilirubin is high, it often indicates liver disease.

Do you know what harms high indirect bilirubin can bring? 1. Bilirubin is the burnt product after the metabolism of scarlet in red blood cells in the blood. If there is a problem in one link, it will cause jaundice.

If the serum bilirubin is too high, it indicates liver lesions or bile duct blockage, and the level of serum bilirubin also indicates the severity of the abnormality. 2. If the red blood cells are destroyed too much, it will lead to excessive indirect bilirubin, and when the liver will not have time to convert it into direct bilirubin, hemolytic hunger will occur. 3. When hepatocytes are diseased, or bilirubin is not converted into bile normally, or because hepatocytes are swollen, the bile ducts in the liver will be compressed, the secretion of bile will be blocked, and the bilirubin in the blood will rise, and hepatocellular jaundice will occur.

Obstructive jaundice can also occur when tumors or tuberculosis occur in the biliary system outside the liver, blocking the biliary tract and preventing bile from being secreted smoothly. What medicine is good for indirect bilirubin high? If it is not particularly serious, it can be conditioned by traditional Chinese medicine, and you can also take drugs that soothe the liver and gallbladder such as chicken bone grass capsules and soothing liver and choleretic tablets, and you still need to follow the doctor's instructions.

Question 2: What causes high indirect bilirubin and total bilirubin? Serum total bilirubin:

It is common in neonatal jaundice, falciparum malaria, transfusion reactions with incompatible blood groups, and hemolysis caused by certain drugs.

Hope Question 3: What should I do if indirect bilirubin is high? 20 points Bilirubin is not a test for hepatitis virus, biliary tract diseases, various hepatocyte damage, too much red blood cell destruction will be high, there are many laboratory errors will be slightly high, there are no clinical manifestations, liver function is normal, don't care about it Light diet

Question 4: What causes high indirect bilirubin and total bilirubin? Serum total bilirubin:

It is common in neonatal jaundice, falciparum malaria, transfusion reactions with incompatible blood groups, and hemolysis caused by certain drugs.

Hope Question 5: Indirect bilirubin is high 29, otherwise normal, what is the cause Condition analysis: Hello, the increase in direct bilirubin in liver function test is meaningful to suggest liver disease, and the increase in indirect bilirubin is not of great significance and is not caused by liver disease.

Suggestions: indirect bilirubin is the most important product of the body's red blood cell metabolism, so if it is mildly elevated, it may be caused by the vigorous metabolism of red blood cells, such as after strenuous exercise, hypoxia, * other conditions of red blood cell regeneration, etc., generally mild elevation is not a big problem, if ** rapid increase, you need to check the blood routine. Your mere test is mildly elevated and doesn't make any sense.

Do not worry. Hope mine is helpful to you and I wish you good health. View the original post