What causes high total bilirubin? What causes high total bilirubin

Analysis: What is the cause of high total bilirubin:

Most of the bilirubin in the body comes from hemoglobin released by the lysis of senescent red blood cells, including indirect bilirubin and direct bilirubin. Indirect bilirubin is transported through the bloodstream to the liver, where direct bilirubin is produced through the action of hepatocytes. Elevated bilirubin is seen in:

1) Liver diseases: acute jaundice hepatitis, acute yellow liver necrosis, chronic active hepatitis, liver cirrhosis, etc.

2) Extrahepatic diseases: hemolytic jaundice, blood group incompatibility transfusion reaction, cholecystitis, cholelithiasis, etc.;

Guidance: b"If the bile mucosa is slightly rough if it is found by ultrasound, whether it is considered a disease." It should be seen if you have discomfort in the biliary area of the right upper quadrant, dull pain, and affect your diet.

If there is no discomfort described above, i.e., rough mucosal hair of the biliary mucosa can only be used as a reference for regular follow-up and observation. Do not treat as a disease. If the clinical symptoms worsen, then the rough mucosal of the biliary can be referred to as a disease.

You have to go to the hospital for further examination.

The lifespan of a person's red blood cells is generally 120 days. After the death of red blood cells, it becomes indirect bilirubin (I-bil), which is converted into direct bilirubin (D-bil) by the liver, which forms bile, is excreted into the biliary tract, and finally excreted in the stool. The sum of indirect bilirubin and direct bilirubin is total bilirubin (T-bil).

Disorders in any of these links can cause jaundice. If the red blood cells are destroyed too much and too much indirect bilirubin is produced, the liver cannot completely convert it into direct bilirubin, and hemolytic jaundice can occur; Hepatocellular jaundice occurs when hepatocytes are diseased, or because bilirubin cannot be converted into bile normally, or because hepatocytes are swollen, which compresses the bile ducts in the liver, obstructs the excretion of bile, and increases bilirubin in the blood. Once tumors or stones appear in the biliary system outside the liver, the bile duct will be blocked, and bile cannot be excreted smoothly, resulting in obstructive jaundice. Jaundice in patients with hepatitis is generally hepatocellular jaundice, which means that both direct and indirect bilirubin are elevated, while in patients with cholestatic hepatitis, direct bilirubin is predominantly elevated.

Most of the bilirubin in the body comes from the hemoglobin released by the lysis of senescent red blood cells, including direct bilirubin and indirect bilirubin, and there are many reasons for high bilirubin, mainly hepatocellular jaundice, hemolytic jaundice and obstructive jaundice.

First, direct bilirubin is high, if the liver cells are damaged, bilirubin can not be converted into bile normally, or bile excretion is blocked, it will cause direct bilirubin to be high, and the common ones that cause direct bilirubin are intrahepatic and extrahepatic obstructive jaundice, pancreatic head cancer, capillary bile duct hepatitis and other bile stasis syndromes.

Second, high total bilirubin may be caused by acute jaundice hepatitis, chronic active hepatitis, cirrhosis, toxic hepatitis, etc., so people with these diseases must be timely **.

Thirdly, high total bilirubin may be caused by intrahepatic and extrahepatic obstructive jaundice, pancreatic head cancer, capillary bile duct hepatitis and other bile stasis syndromes.

Red blood cells are destroyed in large quantities.

When a large number of red blood cells in the human body are destroyed, indirect bilirubin in the human body will increase a lot, and the liver cannot fully convert it, resulting in an increase in indirect bilirubin in the blood. At this time, the main factors that lead to high bilirubin are: leukemia, severe anemia, malaria, hemolytic anemia, etc.

Liver disease. Hepatobiliary disease is usually associated with each other, and patients with a bad liver will find high bilirubin on examination. Because the liver is the site of direct bilirubin and indirect bilirubin conversion, the ability of the liver to convert the two bilirubins in diseases is reduced, so that the bilirubin in the blood increases; At the same time, patients with liver disease have impaired direct bilirubin excretion and reverse flow into the blood.

Patients with liver disease with high bilirubin can cause symptoms such as yellow **, yellow urine, and yellow eyeballs.

Biliary tract disease. Elevated direct bilirubin is common in biliary tract diseases, where direct bilirubin enters the intestine from the biliary tract, and the biliary tract is blocked, and direct bilirubin cannot enter the intestine smoothly and refluxes into the bloodstream, resulting in high bilirubin. At this time, the main ** that causes high bilirubin is:

Gallstones, bile duct tumors, pancreatic head cancer, etc.

Blood transfusion errors. When performing blood transfusion clinically, if the blood type does not match, it will cause hemolysis and destroy red blood cells, resulting in the release of a large amount of indirect bilirubin into the blood, resulting in high bilirubin.

Neonatal jaundice.

Many people don't understand why newborns have jaundice, in fact, it is because the blood type of the newborn and the mother is incompatible, resulting in hemolysis and high bilirubin; At the same time, congenital biliary malformations in reborn children can also cause high bilirubin.

end precautions.

Patients with high bilirubin should eat a light and nutritious diet.

Patients with high bilirubin drink alcohol.

Patients with high bilirubin should do more exercise.

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