Thrombocythemia, essential thrombocythemia

Thrombocythemia is a myeloproliferative disorder that can be primary or secondary. You are so young and don't know what tests have been done, bone puncture, biopsy, chromosomes and JAK-2 genes, BCR ABL fusion genes results? Is the spleen enlarged?

If it is essential thrombocythemia, this disease is mainly hydroxyurea or interferon, which is large, and the condition is easy to recur when the dose is reduced or stopped. This disease is completely difficult, just like chronic diseases such as hypertension and diabetes, through blood circulation and blood stasis removal of traditional Chinese medicine and Qinghuang capsules**, generally about 1 year, after stopping the drug, platelets are maintained at a basically normal level, which does not affect your normal quality of life and life.

I was diagnosed in 2010, I was found when I first entered the university to do a physical examination, I took interferon for more than a year, and now it has been stopped for almost half a year, and the results of the recent examination are about to rise to 1000, I am really helpless to die, my parents are very worried about me, but I have a good mentality, because I think that being a man must give myself a little confidence, let's think about the good side, think about my original 2400, now only 1000 is good, hehe, landlord, let's work together! But then again, playing interferon and taking hydroxyurea *** is really big, I had some symptoms similar to high fever at the beginning when I was taking injections and taking medicine, nausea, vomiting, especially uncomfortable, after a long time, the body sometimes has paralysis and cramps similar symptoms, sometimes in the process of writing, it will suddenly be unable to do it, and it has not appeared again after stopping the drug, I don't know what kind of statement this is. What can patients like us do to help in our daily lives?

I hope you can help answer the answers, thank you for your kindness!

Lou Lou, I am also a patient of thrombocythemia, I have been sick for three or four years, and I have done less examinations, and the doctor only told me that this disease is not cured, and I can only take medicine and injections every day, and I have been tortured to death by injections and Western medicine for more than two years. I'm 22 years old. I have been off medication for almost two years, and in addition to regular check-ups, I don't take medicine or injections, I only pay attention to my usual diet, and live as if I was not sick.

Be happy. Usually insist on drinking olive oil in the morning and evening. It turned out to be 1680 platelets, and it lasted for about half a year, and the basic check is now maintained at 1000.

I believe that if you keep going, it will go down again. I hope what I said works for you.

For this disease, Western medicine will generally choose hormones, but hormones can only be temporarily alleviating the condition, can not fundamentally solve the problem, and the poison is also very large, the important how to fundamentally solve the problem, if you want to fundamentally solve the fundamental problem, you must combine the conditioning of Chinese herbal medicine, Chinese medicine is available all over the country, but the level gap is also very large, the essence of Chinese medicine is concentrated in Beijing, if the local can not **, it is necessary to come to Beijing, Dr. Niu.

The *** of interferon is too big, if you use it for a long time, it is not good, and as you said, it is easier to repeat, this situation can be considered with traditional Chinese medicine to carry out fundamental **, fundamentally adjust the bone marrow, you can pass your bone piercing and the latest blood routine to see how the current situation is and then determine the medication. You can contact at any time, I wish you a speed**!!

I'm the same as you, I found out last year, the hydroxyurea I ate, will also repeat, I don't know what to do? I'm only 26 years old.

From its classification, essential thrombocythemia is a myeloproliferative tumor, not benign, it is classified in myeloproliferative tumor, but it is a very chronic disease, and the chance of leukemia is not very high. It is a tumorous in nature, and in terms of clinical course, it is a benign process if well controlled. What does it mean that this disease is because bone marrow hyperplasia is unrestricted?

For example, our normal human platelets grow, and then it ages and dies, and if our body needs platelets, the bone marrow produces platelets. But once you have this disease, whether you need it or not, it will grow, so the platelets will increase. Thrombocytosis will cause thrombosis, platelets are tube coagulation, so it can cause thrombosis, such as thrombosis occurs in the heart, we call myocardial infarction; If it occurs in the brain, a cerebral thrombosis may occur; It occurs in the lower limbs, that is, blood clots in the lower limbs, which is such a disease.

In this disease, there will be an increase in platelets, so how much it increases is considered this disease, and if we exceed normal, it is an increase, but generally how many platelets are normal, in our words, 10-300,000 L is normal, to 400,000 L or more is considered high, to 500,000 L and 600,000 L is high. But we have to have a few:

First, it is a persistent increase in platelets, and it is a progressive increase. What is persistence? For example, sometimes when there is inflammation, especially when there is acute inflammation, platelets will also be high, and suddenly there is a state of stress, such as going out and crashing, platelets may also be high, which is called a stress state.

Hello, essential thrombocythemia is a clonal disease of pluripotent stem cells, which is characterized by hyperproliferation of bone marrow megakaryocytes, persistent significant increase in platelets and abnormal function, accompanied by repeated spontaneous ** mucosal bleeding, thrombosis, and spleen enlargement, which can lead to intracranial hemorrhage, visceral hemorrhage, and thrombosis, which are life-threatening. In particular, patients with cardiovascular diseases should pay more attention to their condition and pay close attention to it.

For this disease, there are generally no symptoms at the beginning of the onset, and it is generally found back after a physical examination, and there are few symptoms. However, the disease is already the result, the important thing is how to cure the root cause, for this disease, Western medicine can only temporarily treat the symptoms but not the root cause, but cannot solve the fundamental problem. And most of them are very toxic to the body, so it is not recommended to use them for a long time.

The patient's condition is recommended to be combined with the fundamental conditioning of Chinese herbal medicine to achieve the root cause, but Chinese medicine is all over the country, but each Chinese medicine doctor's ** plan is different, and the ** effect and healing that can be achieved are also different, you need to go to an authoritative blood disease specialist hospital to find a recommended expert to diagnose and treat this disease.

Causes of thrombocytosisFor every healthy person, there is a certain amount of platelets in the body, but if there is a sudden increase in platelets in the body, it must be caused by some diseases in the body, so now let's understand what are the main causes of platelet increase?

The first cause is reactive thrombocythemia, which is mainly seen in infections and after surgery and infectious diseases, which often lead to platelet growth and thus thrombocytosis, and the second cause is spontaneous thrombocytosis, which is mainly seen in myeloproliferative disorders. The third cause is primary thrombocytosis, which is mainly due to the relationship between thrombopoietin and hormones in the body, which increases the content of platelets. Therefore, we hope that everyone should eat more healthy food in their lives to avoid some diseases in their bodies.

And we have to have a physical examination once a year, so that some diseases can be detected, and if there are some symptoms in the body, we should go to the hospital immediately for examination.

The above is about the causes of thrombocytosis, so in life, we recommend that you exercise more and participate in more outdoor activities, which can enhance the body's immunity and resist the occurrence of some diseases. In terms of diet, we should also eat more light food and less acidic and spicy food.

Question 1: What does thrombocytosis mean Suggestion: There are many reasons for thrombocytosis, which can be secondary or primary.

It is recommended to go to a hematology hospital for further bone marrow cell morphology, bone marrow biopsy, chromosome and other examinations to confirm the diagnosis; If there is a myeloproliferative disease (including essential thrombocythemia), interferon, hydroxyurea, etc.** can be given, and antiplatelet drugs such as aspirin can be given to prevent thrombosis.

Question 2: What is the cause of thrombocytosis? What are the consequences of severe thrombocytosis There are many causes of thrombocytosis, essential thrombocythemia is a myeloproliferative disorder that needs to be done as soon as possible**, if it is not done properly, the condition worsens, and eventually bleeding or thrombosis may form, or it may deteriorate into acute leukemia.

Question 3: What causes thrombocythemia Primary thrombocytosis (PT)** is unclear, which may be related to physicochemical, biological and other factors. Diseases specifically caused by clonal proliferation of a single aberrant pluripotent stem cell.

The number of disease-causing megakaryocytes, the average megakaryocyte number volume increases, and platelet production may reach 15 times the normal rate. The mechanism by which platelet proliferation leads to bleeding and thrombosis is uncertain.

Question 4: What is the cause of high platelets, and is there any harm The reasons for the increase in platelets include physiological factors and pathological factors.

Physiological normal platelet count can change by 6 to 10% in a day, which is lower in the morning and slightly higher in the afternoon; lower in spring and slightly higher in winter; The plains are inhabited lower, and the plateaus are higher; Venous blood is 10% higher than capillary blood; decreased before menstruation and increased after menstruation in women; increased in the second and third trimesters of pregnancy and decreased after delivery; Elevates after exercise and recovers at rest.

Pathological thrombocytosis: thrombocytosis when it is 400x10 9 l, which is common in myeloproliferative diseases, such as essential thrombocythemia, chronic myeloid leukemia, polycythemia vera, acute massive bleeding, acute hemolysis, malignant tumors, infection, hypoxia, trauma, fractures, etc. Reactive thrombocythemia is common in patients with acute and chronic inflammation, iron deficiency and anemia and cancer, such increases generally do not exceed 500 10 9 l, and the number of platelets will soon drop to normal levels after ** the condition improves.

After splenectomy, platelets are markedly elevated, often above 600 x 10 9 L, and then slowly fall into the normal range.

Hello, this disease is a clonal disease of pluripotent stem cells, which is characterized by hyperproliferation of megakaryocytes in the bone marrow, persistent and significant increase in platelets and abnormal function, accompanied by recurrent spontaneous ** mucosal hemorrhage, thrombosis, and often enlarged spleen.

In severe cases, it can lead to intracranial hemorrhage, visceral hemorrhage, and thrombosis, which are all life-threatening. In particular, patients with cardiovascular diseases should pay more attention to their condition and pay close attention to it.

For this disease, Western medicine is generally chemotherapy or interferon can only be temporary, the treatment of the symptoms can not solve the root problem, the Western medicine programs across the country are similar, this disease wants to fundamentally combine Chinese herbal medicine, but Chinese medicine is available all over the country, each Chinese medicine method is different, the effect is also different, the wrong medication will also delay the condition, a good program is very important.

If there is no way to express your opinion on the local situation, it is recommended to hurry up and come to Beijing, combined with traditional Chinese medicine DBT immunity optimism and thoroughness, so that you can avoid a lot of detours. Agree.

Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) (2008 WHO Revised Criteria for the Classification of Tumors of Chronic Myeloid Cell Line). The disease progresses slowly, often without obvious symptoms, and can survive for more than 10 years or more without serious complications, and the main cause of death is thrombosis-hemorrhagic complications and transformation into leukemia. Therefore, the purpose of ** is to reduce the risk of thrombosis and bleeding, and the second is to reduce the risk of leukemia transformation, so as to improve and improve the quality of life and survival time of patients.

**Commonly used drugs for ET are: aspirin, macride or bolivi, interferon or PEG-interferon 2B (long-acting), hydroxyurea, anagrelide, pipobroman (a piperazine derivative, is a new drug of **ET).

There is no generally accepted best protocol for ET, and stratification is advocated according to prognostic factors and risk of thrombotic complications. Three organizations, including the Italian Society of Hematology, have proposed ** guidelines for ET, the main contents of which are as follows:

1. For those under 40 years old, the first-line ** is interferon or anagrelide; Hydroxyurea is switched only if the patient cannot tolerate it, or if high doses are required to be too toxic.

2. For 40 to 60-year-old patients with a history of thrombosis, the first line is hydroxyurea; If there is no history of thrombosis, interferon or anagrelide is still the first-line** drug.

3. For patients aged 60 to 70 years, hydroxyurea, Maryland or pipobroman can be used as first-line drugs.

4. Patients with microcirculatory symptoms (neurological symptoms, pain or numbness of hands and feet, cyanosis) or recent arterial thrombosis (ischemic stroke, transient cerebral ischemia, acute myocardial infarction or unstable angina), or clinical and laboratory evidence of coronary heart disease, should be given antiplatelet drugs. Aspirin is preferred, and aspiride is reserved for patients who are intolerant or contraindicated to aspirin. For example, if the platelet count is 1500 109 l, in addition to antiplatelet drugs, immediate measures should be taken to reduce the platelet count as soon as possible.

Your father is 52 years old and is recommended for interferon** for 6-8 months.