What diseases should idiopathic thrombocytopenic purpura be distinguished from?

In the course of diagnosis, it should be distinguished from aplastic anemia, acute leukemia, Henoch-Schonlein purpura, Wiskortt-Aldrich syndrome, Evans syndrome, thrombotic thrombocytopenic purpura, secondary thrombocytopenic purpura. According to the specific clinical symptoms, find out the best in order to treat the symptoms, otherwise the condition will be delayed.

This disease belongs to traditional Chinese medicine"Spots"、"Blood evidence"Category,**: Due to the heat and poison, the qi does not take blood, resulting in blood vain; Or it may be caused by liver and spleen deficiency, liver wood and soil, and spleen does not unify blood. If the condition does not heal for a long time, it will lead to spleen and kidney yang deficiency or liver and kidney yin deficiency.

Nourishing blood and nourishing spleen decoction can not only improve blood and replenish blood, but also improve the body's immune function, effectively repair the serious harm to the viscera function caused by the patient's long-term use of hormone retiring drugs and the prolongation of the disease, so that the viscera function can be effectively improved and the body's immunity can be enhanced.

Idiopathic thrombocytopenia, primary thrombocytopenia, sudden thrombocytopenia, and immune thrombocytopenia refer to the same disease.

It is an immunological syndrome and is a common bleeding disorder. It is characterized by the presence of antiplatelet antibodies in the blood circulation, which destroys excessive platelets and causes purpura; In contrast, megakaryocytes in the bone marrow are normal or increased, but they are impaired during maturation and lead to a decrease in platelet production. Platelets mainly play hemostatic coagulation function, low platelets will have the possibility of spontaneous bleeding, mild is subcutaneous bleeding, that is, **purpura, or gum bleeding, nosebleed, serious visceral bleeding or intracranial hemorrhage, is life-threatening.

For specific needs, you need to go to an authoritative hematology hospital and find an experienced expert for diagnosis and treatment.

1) Aplastic anemia: manifested as fever, anemia, bleeding three major symptoms, liver, spleen, lymph nodes are not large, similar to idiopathic thrombocytopenic purpura with anemia, but the general anemia is heavier, the total number of white blood cells and neutrophils are reduced, and the reticulocytes are not high. Bone marrow redness, decreased granulogenetic haematogenesis, and megakaryocytes are reduced or extremely difficult to detect.

2) Acute leukemia: ITP especially needs to be distinguished from leukemia with non-elevated leukemia, and the diagnosis can be confirmed by naïve leukocytes and bone marrow examination that can be seen in the blood smear.

3) Henoch-Schonlein purpura: it is a symmetrical hemorrhagic maculopapular rash, which is more common in the lower limbs and has a lot of platelets, which is generally easy to identify.

4) Lupus erythematosus: thrombocytopenic purpura can be manifested in the early stage, and antinuclear antibodies and lupus cells (LEC) should be checked when suspected. ling3 one one - three six - two nine - three three.

Hello, idiopathic thrombocytopenic purpura, usually less than 20 109 l. Platelet lifespan is significantly shortened, about 1 to 6 hours. Bone marrow examination records most cases of macrokaryocytes or normal, with a marked increase in naïve megakaryocytes.

Idiopathic thrombocytopenic purpura, mostly (30 80) 109 L. Most of the megakaryocytes in the bone marrow are increased, their size is basically normal, the granularity type is increased, and platelet formation is significantly reduced. Increased platelet surface-related IgG and platelet-associated C3.

Platelet life is shortened, about 1 to 3 days. The diagnostic criteria are as follows:

1. Decrease in platelet count by multiple laboratory tests.

2. The spleen is not enlarged or only slightly enlarged.

3. Bone marrow examination has an increased or normal number of megakaryocytes, and there is a maturation disorder.

In addition to primary thrombocytopenic purpura, there are many other diseases that cause thrombocytopenia: aplasia, congenital megakaryocytic thrombocytopenia, thrombotic thrombocytopenia, cyclic thrombocytopenia, hypersplenism, etc.

Idiopathic thrombocytopenic purpura is an acquired autoimmune disease caused by the body's production of anti-platelet autoantibodies, which cause the reticulocortical system to destroy too many platelets, resulting in too few platelets.

The lifespan of platelets is shortened, and they often bleed easily, basically under the skin, and some people have nosebleeds or tooth bleeding.

This is also a relatively difficult disease, which should be related to genetics, but it needs to be paid more attention to in life.

Idiopathic thrombocytopenic purpura will appear **petechiae, ecchymosis, purpura, which is more likely to occur on the trunk** and limbs**, the gum area is easy to bleed, with the development of the disease, there will be anemia symptoms such as fatigue and palpitations, and in severe cases, mild enlargement of the spleen, genital tract bleeding, gastrointestinal bleeding and even intracranial bleeding, which endangers the patient's life. Therefore, in the early stage, glucocorticoids should be used aggressively** to control the disease, and in severe cases, gamma globulin, hemostasis, splenectomy, intravenous platelet infusion, etc. When the bleeding is severe, absolute bed rest is required, reasonable work and rest after the symptoms are relieved, work and rest are combined, and the diet should be nutritious, and eat more foods rich in protein and vitamins.

Idiopathic thrombocytopenic purpura is a syndrome in which there is no significant exogenous** cause thrombocytopenia. This is mainly due to increased platelet destruction due to immune mechanisms. It is also known as autoimmune thrombocytopenia.

This disease is generally caused by children, so when the child is young, parents must have the child's physical condition, if there is any discomfort, so that they must go to the hospital for examination, do not drag, otherwise the condition will be more serious. Therefore, parents need to be careful and take care of them.

Idiopathic thrombocytopenic purpura generally has an insidious onset, mainly manifested in bleeding on the **, or nosebleeds, bleeding gums and other phenomena that can bleed. And purpura and ecchymosis can appear anywhere on the surface. Respiratory infections usually occur in children in the first week or two of acute illness, and some occur after vaccination.

Generally, patients with idiopathic thrombocytopenic purpura will have fever, chills, various bleeding, ** purpura ecchymosis and other manifestations. Therefore, if the child has these conditions, it is necessary to go to the hospital for examination in time to prevent further deterioration of the condition. Because the harm of this disease is still very serious, it will not only cause the most ecchymosis and petechiae, but also lead to intracranial hemorrhage and even death.

And this disease is generally treated with glucocorticoids** or intravenous gamma immune globulin. If the condition is more severe, surgery will be performed**. Therefore, we should pay attention to actively exercising to enhance our own immunity and avoid infection.

Or is it a particularly serious patient, pay attention to bed rest, when the platelet value is lower than a certain level, then you need to strictly bed rest, do not get out of bed and walk around. You should also pay attention to your personal hygiene and avoid going to crowded places. If you go out, it is best to wear a mask and protect yourself from other viruses.

Also pay attention to a regular, light diet.

Decreased number of platelets, ** mucosal bleeding, visceral bleeding, and even nosebleeds, bleeding gums, and a marked increase in menstruation in some patients.

Idiopathic thrombocytopenic purpura can present with generalized ** mucosal bleeding, epistaxis, oral bleeding, gastrointestinal and urinary tract bleeding, and in severe cases, intracranial bleeding.

Nosebleeds, bleeding gums, black stool, headache, paralysis, convulsions, dizziness, ** there will be some bruising on it, these are some of the characteristics that must be checked in the hospital.

Purpura is one of the very common bleeding disorders in children nowadays, so what are the characteristics of idiopathic thrombocytopenic purpura? Let's find out.

1. What are the characteristics of idiopathic thrombocytopenic purpura?

Under normal circumstances, if you have idiopathic thrombocytopenic purpura, then the patient will have thrombocytopenia, and there is irregular bleeding in various parts of the patient, mainly manifested as ** or mucosal bleeding symptoms, and some patients will have **bruising, and in severe cases, there will be blood blisters in the mouth and spontaneous bleeding of the gums, then these conditions indicate that the condition is already very serious. In addition, there are some patients with sudden thrombocytopenic purpura whose symptoms are particularly serious, and there will be conjunctival hemorrhage, and a small number of patients may also have symptoms of cerebral hemorrhage and intracranial hemorrhage, which is likely to lead to the death of the patient, so when the sudden thrombocytopenic purpura is detected, it should be checked in the hospital in time**.

2. How to distinguish Henoch-Schonlein purpura from thrombocytopenic purpura?

1. Usually Henoch-Schonlein purpura will have upper respiratory tract infection about 1 3 weeks before the disease, and there may also be a rash, which is mainly distributed around the distal lower limbs or bare joints of the patient, and some buttocks will also have a rash, in addition, most patients have some abnormalities in the digestive tract before the appearance of Henoch-Schonlein purpura, generally within a week of the rash, abdominal pain or paroxysmal periumbilical colic, In severe cases, bloody stools and vomiting blood may occur.

2. However, thrombocytopenic purpura usually occurs in the baby's childhood, if it is acute thrombocytopenic purpura, it is usually within half a year of the baby, but if it is chronic thrombocytopenic purpura, it is usually over 6 years old. Generally, acute bleeding will be more severe, and upper respiratory tract infection will occur before bleeding, but chronic cases are usually in the baby's preschool age, but the symptoms of bleeding are relatively low.

**purpura, nosebleeds, bleeding gums or visceral bleeding, normal or increased number of megakaryocytes in the bone marrow, and impaired maturation.

Patients will have dizziness, weakness in the limbs, respiratory infections, bleeding from internal organs, hematemesis, hematochezia, and decreased platelet counts.

Bleeding gums, bleeding from internal organs, thrombocytopenia, sickness, fever, and sometimes plaque.

Idiopathic thrombocytopenic purpura is characterized by **hemorrhage, mucosal hemorrhage, cerebral hemorrhage, bleeding, thrombocytopenia, petechiae, and purpura.

Purpura has ecchymosis that can appear in any part of the ** or mucous membrane, commonly found in the lower limbs and distal upper limbs, as well as bleeding spots or bruising spots in the limbs or all over the body, bleeding gums, but gastrointestinal bleeding is relatively rare, and occasionally macroscopic hematuria and so on.

It can cause ** bleeding, nosebleeds, bleeding gums, bleeding from internal organs, and paleness.

Idiopathic thrombocytopenia is an acquired bleeding disorder of unknown cause, characterized by thrombocytopenia, normal or increased megakaryocytes in the bone marrow, and absence of any cause. Also known as autoimmune thrombocytopenic purpura, clinical symptoms are scattered in ** bleeding spots, purpura, ecchymosis, epistaxis, gingival bleeding, etc. Idiopathic thrombocytopenic purpura not only causes ** damage, but also causes intracranial hemorrhage and even death in severe cases.

The incidence is higher in females of childbearing age than in males. Glucocorticoids, intravenous gamma globulin, etc.**, and splenectomy if necessary.

<> generally has an insidious onset, manifested as scattered ** bleeding points and other mild bleeding symptoms, such as epistaxis, gingival bleeding, etc. Purpura and ecchymosis can occur anywhere** or mucous membranes, but are common in the lower and distal upper extremities. The hemorrhagic manifestations of ITP patients are related to the platelet count to a certain extent, and the platelet count can be caused by mild trauma between (20 50) 109 L, and a few are spontaneous hemorrhage, such as ecchymosis, petechiae, etc., the platelet count is less than 20 109 L, there is a risk of severe bleeding, and the platelet count is less than 10 109 L, intracranial hemorrhage may occur.

Examination is usually spalenomegaly, but a few patients may have mild splenomegaly, possibly due to a viral infection. Children with acute ITP may have a history of respiratory tract infection 1 to 3 weeks before the onset of the disease, and rarely after vaccination.

The onset is acute, and a few manifestations are explosive onset, with mild fever, chills, and sudden occurrence of extensive and severe ** mucosal purpura, and even large ecchymosis. **The petechiae are mostly generalized, and the lower limbs are mostly evenly distributed. Mucosal bleeding is more common in the nasal cavity, gums, and stomatology has blood blisters.

Gastrointestinal and urinary tract bleeding is not uncommon, and less than 1% of children experience life-threatening intracranial hemorrhage. If the patient has headache or vomiting, he or she should be alert to the possibility of intracranial hemorrhage. Most patients resolve spontaneously, and a few become chronic if they do not heal.

Answer] :d idiopathic thrombocytopenic purpura is caused by the presence of platelet culture lead and antibodies in the peripheral blood, resulting in thrombocytopenia; hemoglobin abrasion may be normal or reduced; The white blood cell count is usually normal.

extensive bleeding involving **, mucous membranes, and internal organs; decreased platelet count on multiple checks; the spleen is not large or mildly large; bone marrow megakaryocytes are polystoic or normal, with impaired maturation; Possess any of the following five items: aPrednisone** is effective; b.

Splenectomy** effective; Masculine; Masculine; e.Platelet survival is shortened.

The differential diagnosis should be confirmed by excluding secondary thrombocytopenia.

1.Platelets Acute platelets are mostly less than 20 109 L, and chronic types are often around 30 109 L. Platelet morphology is normal, the average volume is large, and large platelets are easy to see; prolonged bleeding time, poor clot contraction; Platelet function is usually normal.

2.Bone marrow elephant The number of myeloid megakaryocytes is mildly increased or normal in acute form, and the number of myeloid megakaryocytes in chronic form is markedly increased; Megakaryocyte maturation disorders, especially in acute cases; There was a significant decrease in giant cells with platelet formation (<30%).

More than 80% of patients with platelet-associated complement (PAC3) are positive for PAIG and PAG, and the main antibody component is IgG or IgM, and occasionally more than two antibodies appear at the same time.

4.In more than 90% of other patients, platelet survival was significantly shortened. There may be varying degrees of normal red blood cell or microcytic hypochromic anemia, and rarely evidence of hemolysis (Evans syndrome).

In patients with chronic hypertension, the lower limit of self-regulation can be increased to MAP100 120 mmHg, and the upper limit can reach 150 160 mmHgThis range is called the auto-adjustment threshold. Adverse effects of high or low blood pressure on brain function:

Once the blood pressure rises above the autoregulatory threshold, it will lead to hyperperfusion of cerebral blood flow and cerebral edema.

If blood pressure falls below the lower threshold of autoregulation, hypoperfusion occurs.