How to design and build an intravenous drug dispensing center?

Intravenous Drug Dispensing Center: An institution that provides high-quality products and pharmaceutical services for clinical practice.

Intravenous drug dispensing center is a hospital that provides high-quality code products and pharmacy services for clinical practice.

Hospital Cleanroom: SICOLAB Intravenous Drug Dispensing Center Who Design Standards:

Daily dispensing of 1001-2000 bags (bottles): the area of the dispensing center is 300-500;

Daily dispensing of 2001-3000 bags (bottles): the area of the dispensing center is 500-650;

Mix more than 3001 bags (bottles) per day, and increase by 30 for each additional 500 bags (bottles).

clean areas, auxiliary work areas and living areas;

The location should be kept away from various pollution sources, and it is forbidden to set it up in basements or semi-basements;

The clean area shall include a dressing room, a secondary dressing and a deployment operation room;

The auxiliary work area shall contain corresponding functional rooms for the storage of drugs and materials, the printing of prescriptions, the preparation of medicines, the verification of finished products, packaging and ordinary dressing.

Separate antibiotic drugs from hazardous drugs and parenteral nutrition solution drugs from ordinary intravenous drugs. It is necessary to establish two sets of independent air supply and exhaust (return) systems.

Cleanliness level requirements for each functional room:

A dressing room and laundry room are 100,000 levels;

The secondary dressing room and the dosing mixing and dispensing operation room are 10,000 levels;

The laminar flow console is 100 levels.

The shower room and toilet shall be set up separately outside the center (room), and shall not be set up in the intravenous drug dispensing center (room).

With the development of modern medical technology, the first mode of intravenous infusion of liquid drugs has been transformed from open and semi-open to fully closed infusion. In the world's pharmaceutical industry, the implementation of Good Manufacturing Practice (GMP) enables the whole process of drug production, with quality as the core, to carry out dynamic management and control of the whole production process to ensure the production of high-quality drugs. In the process of drug circulation, the implementation of Good Manufacturing Practice (GSP) enables the quality of drugs to be guaranteed in the process of procurement, storage and distribution.

Clinical medication in hospitals: The dissolution and configuration of drugs are carried out in a non-clean environment, while the infusion is carried out in a semi-open state, which causes problems such as drug contamination, unreasonable compatibility, adverse drug reactions, cross-infection, cross-resistance, and long-term inhalation or exposure to chemotherapy drugs, antibiotics and other drugs caused by operators. In the long run, it will not only reduce the clinical efficacy of drugs, and even cause serious accidents, but also damage the health of medical staff.

This situation of cleaning first and then polluting makes it impossible for high-quality drugs to ensure their quality and efficacy in the process of clinical use.

In order to solve the above problems, the intravenous drug dispensing center PIVAS came into being.

In 1969, the world's first pivas was established at Ohio State University Hospital in the United States. Subsequently, hospitals in the United States and other European countries have established their own pivas. Today, it has developed into one of the important tasks of hospital pharmacists.

As early as 1999, 93% of for-profit hospitals in the United States had pivas, 100% of non-profit hospitals had pivas, and teaching hospitals in the United States, the United Kingdom, Australia, and New Zealand in western developed countries had pivas.

In addition to ensuring the rational use of drugs by patients, the development of pivas work also has great advantages in ensuring the quality and safety of drugs.

First of all, due to the high cleanliness of the configuration environment, standardized preparation links, and strict aseptic operation, the chance of drug powder contamination and pathogen contamination is minimized, so as to ensure the sterility of the solution;

Secondly, due to the strict implementation of each process, to ensure the compatibility and stability of the drug, to ensure the high quality of the infusion drug, and to use a unified label, at the same time multiple checks, so that the preparation error is minimized;

In particular, after the pharmacist compounds, the pharmacist will strictly inspect the particles and clarity in the infusion according to the requirements of the pharmacopoeia, which cannot be done in the traditional infusion preparation, and this process plays an important role in ensuring the high quality and safety of the infusion drug;

In addition, due to the centralized management of drugs, the loss of drugs can be reduced, and the expiration date drugs can be used rationally in chronological order to prevent drug failure, resulting in waste or expired drugs being used, affecting the effect of drugs and even causing unnecessary legal disputes;

Through centralized allocation, the use of drugs can also be reasonably arranged, so that only partially utilized drugs are not wasted, and the cost of sub-dose is reduced;

Intravenous drug dispensing centers should be located in quiet areas with low flow of people, and facilitate communication with medical staff and delivery of finished products. The setting site should be far away from various pollution sources, and it is forbidden to set up in basements or semi-basements, and the surrounding environment, road surface, vegetation, etc. will not pollute the intravenous drug dispensing process. The air collection outlet in the clean area shall be set up in a clean and pollution-free area within 30 meters of the surrounding area, and the height from the ground shall not be less than 3 meters.

The room of the intravenous drug dispensing center should have sufficient lighting, and the wall color should be suitable for human vision; The ceiling, walls, and ground should be flat, smooth, and non-slip, easy to clean, and there should be no falling objects; There shall be no cracks in the ceiling, wall and floor in the room in the clean area, which can withstand cleaning and disinfection, and the junction should be arc-shaped and the interface should be tight; The building materials used shall meet the requirements of environmental protection.

The clean area of the intravenous drug dispensing center shall be equipped with temperature, humidity, air pressure and other monitoring equipment and ventilation facilities, maintain the temperature of the intravenous drug dispensing room 18 26, the relative humidity of 40% 65%, and maintain a certain amount of fresh air intake.

The intravenous drug dispensing center is divided into a clean area, an auxiliary work area, and a living area, which are relatively independent.

1. Class 100 clean area: laminar flow workbench, biological safety cabinet.

2. 10,000-level clean area: secondary dressing room, ordinary drug dispensing room, hazardous drug dispensing room.

3. 100,000-level clean area: a dressing room, a clean cleaning room.

4. Control area: the review printing area, the medicine area, and the finished product checking and packaging area.

5. Ordinary area: ordinary locker room, office, conference room, secondary medicine warehouse, distribution waiting area, air-conditioning room, material room, etc.