Is it better to take Gleevec or bone marrow transplant for chronic myeloid leukemia?

After 3 years of bone marrow transplantation, less than 10% of people survive.

Gleevec, after many years of eating, the liver will be scrapped, and the disease will change rapidly. Still can't live.

This disease can be done by Chinese medicine. Negotiable. Cure first, pay later.

Bone marrow transplantation is the only way to treat leukemia, but the success rate of transplantation is about 50-60%; The chances of post-transplant ** are not low; Poor effect after transplant failure; Taking Gleevec is to control the disease in the chronic phase, which requires long-term medication, and how long it can be controlled is not good**;

Integrative medicine is recommended** Leukemia.

Slow granules can be treated with a combination of traditional Chinese and Western medicine**.

Doctor Analysis:

Gleevec is a drug that specifically targets the BCR-ABL tyrosine kinase, which can inhibit the binding site-specific binding of the ABL tyrosine kinase ATP, thereby blocking the binding of ATP to ABL. This can inhibit the process of ABL transfer of the phosphate group on adenosine triphosphate to the phosphorylated group containing the tyrosine residue protein, thereby preventing the transfer of energy required for ABL-induced cell proliferation and apoptosis.

In general, it is to keep the slow granules in the chronic phase and to keep the disease from progressing to blast or accelerated phases. Once the abrupt change is very dangerous, a bone marrow transplant can theoretically completely ** leukemia. But the problem is that it is difficult to find a match, the second is the high cost, and the third is the high risk, so it is necessary to weigh the pros and cons and make the best choice.

Gleevec can control the slow grain, but it can't. Therefore, if you want to be the best in slow grains, you can only transplant them.

It is also reasonable for doctors to urge, because of the individual differences of each person, some people can have a long effect after taking Gleevec, while others have a short effect, and once they enter the blast period, it is more troublesome.

And the preparation stage for transplantation is also time-consuming.

Of course, the doctor may have other considerations, and whether to do it or not needs to weigh the pros and cons before deciding, no one will make the decision for you, it is all up to you.

If the chronic granule pH is positive and responds well to Gleevec, it can be transplanted without bone marrow, and the efficacy is similar to that of bone marrow transplantation, of course, you need to continue to eat.

Don't listen to the doctor, if you take medicine to maintain it, you must take medicine to maintain it, so that the patient does not need to be as painful as chemotherapy, and will not worry about the risk of transplantation.

Simply put, Gleevec has a better chance of maintaining long-term survival.

Before the advent of Gleevec, patients with chronic granules were known as "incurable for three and a half years", that is, after the use of hydroxyurea, the chance of patients to survive for 5 years is also very small, but after the leukocytes are lowered, the related symptoms of leukocyte stasis and the occurrence of fatal complications such as splenic rupture caused by leukocyte hyperproliferation may be smaller.

If interferon and hydroxyurea are combined, it costs hundreds of yuan per month, which improves the survival chance of patients to a certain extent, and a small number of patients can be seen who have been maintained for more than ten years. But this method still can't slow down the grain.

Gleevec is a gene-targeted ** drug that appeared at the beginning of this century, and in the past 10 years, more than 80% to 90% of patients can still maintain the chronic phase of the disease and carry out their daily life normally with oral administration alone. However, this drug is only inhibited from the level of downstream products of genes, that is to say, it cannot achieve the efficacy of ** from the level of genes, and it is currently believed that lifelong medication is required, ** is indeed too expensive, after applying for the charity federation to buy three and get nine free, the current average annual cost is between 7-80,000. It is true that there are fewer patients who can afford it.

At present, the only way to slow grain is still bone marrow transplantation, but the physical condition of the patient is high, and the donor matching also depends on chance, the cost is about 20-300,000 yuan, and more than half of the chances are obtained.

At present, the most important measures for slow grains in China are the above means. You should choose the appropriate strategy according to your specific situation.

In addition, now some international multi-center clinical trials are including patients with chronic granules, if you are in Changsha, you can go to the hematology department of Xiangya or nearby Tongji and other large tertiary hospitals to consult whether there are clinical trials such as flumatinib, nylontinib, dasatinib and so on that are still including patients, if you meet the enrollment conditions, you can save some costs.

Hello chronic myeloid leukemia is a malignant clonal disease of the bone marrow, which is divided into chronic phase, accelerated phase, and blast crisis phase. 90% of patients are positive for the ABCR-ABL fusion gene, so doctors will recommend Gleevec, which is mainly for this fusion gene. However, the cost is more expensive.

For patients who cannot pay for Gleevec, it is recommended to use a combination of Western medicine**, hydroxyurea or interferon in Western medicine, and traditional Chinese medicine to dispel stasis and knots, detoxify and dispel evil spirits, which can effectively reverse the gene and make it negative. Moreover, it can effectively achieve complete remission, and the blood and bone marrow images return to normal.

Generally, white blood cells, hemoglobin, and platelets can be maintained in the normal range, and the blasts in the bone marrow do not increase, which is the best effect, but at present, the purpose of chronic myeloid leukemia is no longer simply to control the disease, and it is the requirement of every patient to achieve clinical treatment. Therefore, it is necessary to actively integrate traditional Chinese and Western medicine**, which can be clinical**.

The mere reduction of white blood cells is only a superficial phenomenon. Gleevec is a good choice for prolonging life.

Prices in India are lower. It is recommended to try.

**, Indian Gleevec. q Me.

Gleevec has a good effect, hydroxyurea is not, if you can't afford to eat Swiss, you can eat India, or Gleevec has a good effect.