Why do the cell markers of chronic myeloid leukemia go high and low?

I think it has something to do with the dosage of the medication. Because hydroxyurea lasts for a short time, the white blood cell count decreases 2-3 days after taking the drug, and it rises quickly after stopping the drug. The usual dosage is:

3 g a day, orally in 2 divided doses. The dose is halved when the white blood cells drop to 20 10 to 9 l, and to maintain ** when the leukocytes drop to 10 10 to 9 l. Blood counts are checked frequently to adjust the dose during medication.

Hydroxyurea tablets are currently the first choice for slow granules.

Yes, it has a certain relationship with the patient's medication, diet, rest, mood, etc. In addition, while taking medicine, remember the combination of traditional Chinese and Western medicine, and the single Western medicine is too big. If there is anything you don't understand, you can tell me about the patient's situation, and I can give you some advice.

a.The spleen is mildly enlarged and soft in texture.

b.The spleen is moderately enlarged and hard in texture.

c.The spleen is highly enlarged and has a smooth surface.

d.The spleen is enlarged, the surface is not smooth, and there are nodules.

e.There is a cystic mass on the surface of the spleen.

Correct and Swift Missing Answer: c

Hello, the early symptoms of leukemia are mainly as follows:

1. Anemia: It is often the first symptom of leukemia, mainly manifested as paleness, weakness, fatigue, sweating, shortness of breath and rapid heartbeat during activities and rest. It gets worse over time, and the more severe the anemia, the more severe the leukemia.

2. Fever: More than half of the patients have fever as the early manifestation, which can be a low-grade fever below 38 degrees or a high fever of 39 degrees or even above 40 degrees.

3. Unexplained swelling: Most leukemia patients have superficial lymph node enlargement, which is more common in the submandibular area, neck, supraclavicular bone, armpit and groin, often without obvious pain, and physical examination can find hepatosplenomegaly, and there is obvious tenderness under the sternum, which is a manifestation of a large number of leukemia cells infiltrating the bone marrow.

4. Bleeding: Nearly 40% of leukemia has bleeding as the early manifestation. Bleeding can occur in all parts of the body, commonly found in **unexplained ecchymosis, oral cavity, nasal cavity, gingival bleeding, menorrhagia, headache, nausea, vomiting, hemiplegia, loss of consciousness and other neurological symptoms are due to leukemia's infiltration of brain cells and meninges.

The early symptoms of leukemia should be paid attention to in time, and cancer prevention should be done at ordinary times. Pay attention to enhance your physical fitness, exercise more, and also take some drugs to improve immunity and prevent cancer, such as ginsenoside rh2 (life protector), which not only prevents cancer but also is non-toxic.

1.Your blood routine physical examination report is analyzed as follows:

1) White blood cell count, indicating a slight decrease in the total number of white blood cells in the peripheral blood.

2) The absolute value of neutrophils indicates that neutrophils are significantly reduced, and the criteria for neutropenia have been met (the absolute value of neutrophils is lower than that of granulocytopenia, and its clinical significance is: in this case, the chance of infection and fever is higher than that of normal people; However, agranulocytosis is not met [below the criteria, the chance of developing a serious infection does not increase).

2.Improvement methods.

1) Change the recipe and change the cooking method: a new food can promote appetite, for example, patients who often eat pork food can replace the eating of fish, shrimp, crab, chicken, etc., and if possible, you can eat some turtles and soft-shelled turtles. Changing the cooking method to give food a different flavor and flavor can also increase appetite.

However, no matter what kind of food, it must be cooked to the level that the food is relatively cooked and rotten, so that it can be digested and absorbed smoothly.

2) Medicinal diet appetizing and spleen: Hawthorn diced meat: 100g of hawthorn, 1000g of lean pig (or beef) meat, 250g of vegetable oil, and appropriate amounts of mushrooms, ginger, green onions, pepper, cooking wine, monosodium glutamate, and sugar.

First, cut the lean meat into slices, burst it in oil, and then use hawthorn seasoning and other fontanelles to burn it dry, and then it can be eaten. It is both appetizing and anti-cancer. Astragalus yam soup:

Use 30g of astragalus, add water and boil for half an hour, remove the slag, add 60g of yam tablets, cook for another 30 minutes, add sugar (add honey for constipation). Take 1 time daily in the morning and 1 time in the evening. It has the effect of invigorating qi and activating blood, increasing appetite and improving gastrointestinal absorption function.

3) Eat more fresh vegetables and fruits that are high in vitamins: These foods can not only increase immunity, but also increase appetite. Some patients believe that raw and cold foods should be avoided, but fruits and vegetables should be treated as appropriate.

In the early postoperative period, vegetable juice and a small amount of easily digestible fruits can be eaten, and the amount should not be too much at a time, and small meals should be eaten. After the basic recovery of gastrointestinal function, you can eat some light and refreshing raw cold vegetables and fruits, especially during chemotherapy and radiotherapy, which have obvious appetizing effects.

You didn't say how low it was, it's hard to judge. It is best not to have white blood cells as low as 1800. Normal adults are 4,000-10,000.

Acute leukemia is a clonal malignant disease originating from hematopoietic stem cells. Excessive proliferation of any type of abnormal primitive or naïve cells in the bone marrow and other hematopoietic tissues, and release into the peripheral blood, resulting in inhibition of the production and reproduction of other cells in the bone marrow and infiltration of leukemic cells in various organs. The clinical manifestations are anemia, secondary infection, hemorrhage, hepatosplenic lymphadenopathy and other infiltrative manifestations.

The hemogram may show elevated leukocytes, erythrocyte and platelet depletion or pancytopenia, and a large number of naïve cells. The disease progresses rapidly, with a natural course of only a few months.

Acute myeloid leukemia is a very dangerous type of acute leukemia, and its bleeding symptoms are very common, with an incidence of 72% and 94%, which is significantly higher than that of other acute leukemias, and is often a manifestation of disseminated intravascular blood (DIC), especially in the process of chemotherapy, DIC can be aggravated, often leading to early death of patients. Chemotherapy sensitivity (<5% incidence of chemoresistance) and long survival in remission but high early mortality.

Chronic myeloid leukemia (c**) is a malignant myeloproliferative disorder that occurs on pluripotent hematopoietic stem cells (acquired hematopoietic stem cell malignant clonal disease), primarily involving the myeloid lineage. It is clinically characterized by a marked increase in peripheral blood granulocytes and immaturity, and the pH chromosome and BCR-ABL fusion genes can be found in the affected cell lines. An enlarged spleen is often the most prominent sign.

It can occur at any age, but it is more common in middle age and more often in men than in women. The onset is slow, there may be no self-conscious symptoms in the early stage, often the spleen has reached the umbilical level when seeking medical attention, the texture is firm, the surface is smooth, there is no tenderness, and there can be obvious tenderness and friction rub during splenic infarction. In the early stage, the number of white blood cells in the blood image is significantly increased, often exceeding 20 109 L and reaching more than 100 109 L.

Platelets are mostly at normal levels, and some patients have an increase; In advanced stages, platelets decrease and anemia develops. Bone marrow hyperplasia is marked to extremely active, with granulocytes predominant, and the granulocyte:red ratio is markedly increased.

Analysis: Given what you said, it's hard to draw conclusions. Because these two diseases are different diseases.

Thrombocythemia is a myeloproliferative disorder characterized by bleeding tendencies and thrombosis, a persistent and significant increase in peripheral blood platelets, abnormal function, and excessive proliferation of bone marrow megakaryocytes. Chronic myeloid leukemia is a malignant tumor affecting the blood and bone marrow, which is characterized by the production of a large number of immature white blood cells, which accumulate in the bone marrow and inhibit the normal hematopoiesis of the bone marrow; It can also spread throughout the body through the blood, causing patients to develop anemia, easy bleeding, infection and organ infiltration.

Suggestions: In view of the situation you said, it is difficult to draw conclusions, and it is recommended to go to the hematology department of a regular hospital for bone puncture for diagnosis.

Platelets mainly play hemostatic coagulation function, low platelets will have the possibility of spontaneous bleeding, mild is subcutaneous bleeding, that is, **purpura, or gum bleeding, nosebleed, serious visceral bleeding or intracranial hemorrhage, is life-threatening.

Leukocytes are mainly responsible for defense, and they can engulf foreign bodies to produce antibodies, which play an important role in the body's damage**, resistance to pathogen invasion and immunity to diseases. Leukopenia will lead to a decrease in the body's resistance, various pathogens are easy to invade, patients are prone to various diseases, neutrophils are lower than 10 times the 9th power, prone to repeated infections, and the disease is slow, and can even cause sepsis, which is also life-threatening.

There are many factors that can precipitate these two diseases, such as fatigue, inattention to diet, cold, inflammation, viral infection, radiation, chemical poisons, and ionizing radiation.

Many blood diseases can cause thrombocytopenia, low white blood cells, low neutrophils, and high lymphocytes, and it is necessary to pay attention to 1. The specific value of blood routine, the specific proportion of five types of cells in the manual differential count of white blood cells, whether there are blast cells, cell morphology, etc., and the specific diagnosis requires detailed disease information.

Stem cells are usually transfused through peripheral blood, and bone marrow recovery depends on transplantation.

Chronic myeloid leukemia usually has an increase in basophils and eosinophils, but in the case of Glive*** effective, usually these two indicators will decline, so I suggest that your father recheck the bone marrow, chromosomes and fusion genes, Dr. Qiu Huiying solemnly reminded: Because the patient cannot be seen face-to-face, the condition cannot be fully understood, the above suggestions are for reference only, please go to the hospital for specific diagnosis and treatment under the guidance of the doctor! ）

Qiu Huiying, Suzhou First People's Hospital.