Is it good to take sulfonamides for a long time? What should I pay attention to?

Try to take as few antibiotics as possible, this is advice.

Drink plenty of fluids when taking sulfonamides.

I am a pharmacist in the hospital, and I can tell you clearly: no, the main representative drugs are neoxinazole, and you should drink more water when taking sulfonamides! Nowadays, sulfonamides are basically not used in hospitals!

It's not good, antimicrobials can't be used for a long time, bacteria are prone to drug resistance, kidney damage, and the hematopoietic system reaction is mainly granulocytopenia regenerative anemia

1 Sulfonamides can cross the blood-placental barrier into the fetus, and animal experiments have found that they have teratogenic effects. Sulfonamides can be secreted from breast milk, and the concentration in milk can reach about 50% to 100% of the maternal blood concentration, and the drug may affect the baby; The use of sulfonamides in neonates with glucose-6-phosphate dehydrogenase deficiency may lead to hemolytic anemia. There is a lack of sufficient information on human research, and pregnant women should avoid using Zheng liquid.

2 Because sulfonamides can compete with bilirubin for the binding site of plasma proteins, and the acetyltransferase system of newborns is not well developed, the free blood concentration of sulfonamides increases, which increases the risk of kernicterus, so the use of these drugs in neonates and infants under 2 months of age is contraindicated.

3.Older patients have an increased chance of serious adverse effects when sulfonamides are used. Such as severe rash, bone marrow suppression and thrombocytopenia. Therefore, it should be avoided in elderly patients, and it is necessary to weigh the pros and cons when there are indications.

It is forbidden to use in the following groups:

1.Contraindicated in patients with allergies to sulfonamides. 2.

Because this product prevents the metabolism of folic acid and aggravates the lack of folate in patients with megaloblastic anemia, this product is contraindicated in patients with this disease. 3.Pregnant and lactating women should not use this product.

4.This product is contraindicated for infants less than 2 months old. 5.

Patients with liver and kidney function impairment are prohibited from using this product;

Because this product can inhibit the growth of E. coli and hinder the synthesis of B vitamins in the intestine, those who use this product for more than a week should be given vitamin B at the same time to prevent its deficiency.

Folic acid preparations can be taken at the same time, the latter does not interfere with the antibacterial activity of TMP, because bacteria can not use the synthesized folic acid, if there are signs of myelosuppression, this product should be stopped immediately and folic acid 3-6mg intramuscularly injection, once a day, used for 2 days or as needed until the hematopoietic function returns to normal, for long-term, excessive use of this product can be given a high dose of folic acid and prolong the course of treatment.

Mechanism of pharmacodynamics of sulfonamides.

Mechanism of action Sulfonamides are bacteriostatic drugs, which inhibit the growth and reproduction of bacteria by interfering with the folate metabolism of bacteria. Unlike human and mammalian cells, bacteria that are sensitive to sulfonamides cannot directly use folic acid in the surrounding environment, but can only use para-aminobenzoic acid (PABA) and dihydropterine to synthesize dihydrofolate in bacteria by the catalysis of dihydrofolate synthase, and then form tetrahydrofolate through the action of dihydrofolate reductase. The activated form of tetrahydrofolate is a one-carbon unit transporter that plays an important transport role in the formation of purines and pyrimidine nucleotides.

The structure of sulfonamides is similar to that of PABA, which can compete with PABA for dihydrofolate synthase, hinder the synthesis of dihydrofolate, affect the production of nucleic acids, and inhibit the growth and reproduction of bacteria.

Sulfonamides can be divided into:1Sulfonamides used for systemic staining According to the length of plasma T1 2, drugs are divided into three categories:

Short-acting (10 hours), intermediate-acting (10-24 hours) and long-acting (24 hours). 2.Sulfonamides for intestinal infections 3

Topical sulfonamides.

Sulfonamides are synthetic antibacterial drugs, which have been used in clinical practice for nearly 50 years, and they have the advantages of a wide antibacterial spectrum, stable properties, easy to use, and no food consumption during production. Especially after the discovery of the antibacterial synergist - trimethoprim (TMP) in 1969, the combined application with sulfonamides can enhance its antibacterial effect and expand the range, so although a large number of antibiotics have been introduced, sulfonamides are still important chemical drugs.

Details can be found in the encyclopedia.

Hope it helps!

There are three main types of common sulfonamides: sulfonamides that are easily absorbed in the intestines, sulfonamides that are difficult to absorb in the intestines, and sulfonamides that are difficult to absorb in the intestines.