I urgently need the meaning of the immunohistochemistry results of the pathological diagnosis report

In fact, cancer does not occur in the first place, only in the first place, and the root of the disease cannot be cured by cutting the tumor. It's like cutting leeks, as long as the roots are there, they will grow. It's just that cancerous cells exist in the human body, and as long as they are suitable for development, they will manifest themselves in the form of tumors wherever they are.

To do ER and PR, this result determines which regimen to use**, endocrinology** is recommended if the situation is good, breast conservation or not, and the comprehensive conclusion is based on the patient's tolerance and the doctor's recommendation. It is important to communicate with the patient more, reduce the psychological burden, and have an optimistic and positive attitude, which is especially important during and after the operation. I hope Auntie will be soon**!!

Summary. Hello dear, I am happy to answer for you Hello According to the situation you described, the patient is now in love with a lover, and it is poorly differentiated, and the degree of malignancy is relatively high.

Suggestions: The patient's current surgical plan is more correctAfter surgery, the tumor site will be removed, and then some better chemotherapy drugs will be used, and chemotherapy will be used for 2 to 6 courses. Generally, after chemotherapy, some traditional Chinese medicine anti-tumor drugs can be used to continue, which should be of some help to patients.

Pathologic diagnosis: (right breast mass) invasive ductal carcinoma of the breast (poorly differentiated, size.

Hello dear, I am happy to answer for you Hello According to the situation you described, the patient is now in love with a lover, and it is poorly differentiated, and the degree of malignancy is relatively high. Suggestions: The patient's current hand-holding fibrillation ** plan is more correct, after the operation, the tumor site is removed, and then some better chemotherapy drugs are used to eliminate the fissure for 2 to 6 courses.

Generally, after chemotherapy, you can use some anti-tumor drugs of traditional Chinese medicine with a large source and continue to **, which should be of some help to patients.

Is it better to have surgery or chemotherapy first?

That's the first to do it. Hello dear, it's better to have surgery first.

The hospital recommends chemotherapy first.

If the hospital recommends chemotherapy first, you listen to the local hospital, and I can't know exactly what you're going to do.

C-ERBB-2 as the target of breast cancer** strategy C-ERBB-2 is closely related to the occurrence and development of breast cancer, and is an important molecular marker and target of breast cancer. In-depth research into the signal transduction mechanisms of the ERBB family has opened up a broad path for breast cancer targeting**, the most successful example of which is the targeting of C-..

If the size of the lump is small and no cancer metastasis is seen, it is considered to be stage 1 breast cancer, that is, early stage;

The tissue grade was grade 2, indicating poor differentiation and strong invasion and metastasis ability.

ER-A positive, suitable for endocrine**;

Moderate positive KI-67 indicates that cancer cells are more active in proliferation and require systemic chemotherapy after surgery.

Negative FISH, suggesting no need for targeting**;

If breast-conserving surgery is performed, whole-breast radiotherapy should also be combined;

Based on the above pathological results, it is considered to be Luminal B breast cancer, and the comprehensive effect is better, especially the early stage, the 10-year survival rate is high, and there is a possibility of ***.

ER, PR: ER, PR are present in normal mammary gland epithelial cells. When cells become cancerous, ER and PR are partially and completely missing.

If the cells still retain ER and/or PR, the growth and proliferation of this breast cancer cell is still regulated by endocrine and is called hormone-dependent breast cancer; If ER and/or PR are missing, the growth and proliferation of this breast cancer cell is no longer regulated by endocrine and is called hormone-independent breast cancer.

C-Erbb2 oncogene: It is expressed in normal breast tissues, and its expression rate can be increased in breast cancer tissues, and its expression is positively correlated with breast cancer grade, lymph node metastasis and clinical stage, and the higher the expression rate, the worse the prognosis may be.

p53 gene: breast cancer cells with high p53 mutation rate have strong proliferative activity, poor differentiation, high malignancy, strong aggressiveness and high lymph node metastasis rate.

Cox-2 (cyclooxygenase-2): expression of Cox-2 is present in breast cancer tissues. COX-2 may be a useful indicator for clinical evaluation of patient prognosis and identification of high-risk patients after surgery.

I am a breast surgeon.

1, ER, PR, on behalf of estrogen receptor and progesterone receptor, positive good, indicating that you can eat endocrine ** drugs.

2. C-ERB-B2 represents an invasive metastatic capacity of breast cancer, and negative is a good result.

3. Because it is a grade 3 invasive ductal carcinoma with metastasis of axillary lymph nodes, I think chemotherapy is necessary, and the drug selection of paclitaxel is also reasonable and standardized. (But if I had to choose, I probably wouldn't either.) I'll give you some of my personal advice:

The immunohistochemistry results you provide are not comprehensive, at least you should go to recheck a KI67, if KI67 <14%, I will choose 4 times of EC epirubicin + cyclophosphamide, and 5 oral endocrine ** drugs after chemotherapy, because the current research believes that this type of breast cancer is not too sensitive to chemotherapy, but very sensitive to endocrine **, instead of doing 6 times of chemotherapy, it is better to start endocrine ** early after 4 times**, if KI67>14%, I would choose 4ec-4t or 6 cef followed by endocrine**. My opinion is for reference only, I am only giving my opinion based on the little information you gave, because your attending doctor may have a better understanding of the patient's situation and has more comprehensive information, and you should mainly listen to him. )

4. Actively go to the **, adjust the mentality, the prognosis of breast cancer patients is still relatively good, and there are many people who live a long life. So don't give up hope.

Chemotherapy and endocrine therapy are required after surgery, followed by radiotherapy consolidation** after the end of chemotherapy if the patient has lymph node metastasis.

Analysis: Hello, your situation is considered for breast cancer lymphatic metastasis, and then checked after six rounds of chemotherapy, if there is no metastasis, there is no problem.

Suggestions:

The drug is still reasonable with paclitaxel plus platinum This result roughly shows that it is an advanced stage of breast cancer Lymphatic metastasis Chemotherapy *** is relatively large At the same time, it should be combined with wuzhiye so that *** is relatively small.

Must be combined with traditional Chinese medicine**, prevention** and metastasis.

If breast hyperplasia is not timely, it will lead to breast cancer, which cannot be diagnosed by symptoms, you can go to the hospital for a detailed examination to diagnose it, and breast cancer can be diagnosed, don't be pessimistic, the effect of Chinese medicine on **tumor is very good.

Breast cancer COPY immunohistochemistry mainly looks at the four values of ER, PR, HER-2 and KI67, and the rest is not of much guiding significance.

To put it simply:

It is a hormone receptor test, and a positive one indicates that it can be endocrine ** and the prognosis is better, because the positive one is a hormone-dependent tumor, and on the contrary, the negative prognosis is poor and the endocrine ** is not sensitive.

It is an oncogene test, and whether it is suitable for targeting** refers to the test results mainly through it, but it has also been clinically confirmed that the positive prognosis is poor, and the metastasis rate is higher.

The higher the positive, the greater the impact on cancer cell proliferation and the higher the activity of cancer cells!

4.**Chemotherapy is the mainstay, if there are economic conditions, it can be targeted**.

Chemotherapy is needed from the size of the tumor alone, and Herceptin can be added on the basis of adjuvant chemotherapy, as for what regimen to use combined with axillary metastasis, and personal conditions

Is there any metastasis of lymph node cancer?