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5-Fluorouracil.

Molecular mechanisms of cell death.

Daniel BLongley and Patrick GJohnston.

Summary. 5-fluorouracil (5-fu) has been the leading cause of colorectal cancer for more than 40 years.

However, in advanced colorectal cancer, the 5-fu response rate is mild. Although combined.

The new chemotherapy drugs 5-fluorouracil and oxaliplatin, irinotecan have an improved response.

rate, a new ** strategy is necessary. Understanding the molecular mechanisms.

The need to become anti-tumor to 5-fu if resistance is overcome. Tumor drug resistance.

Cell death is usually caused by inadequate chemotherapy. In this chapter, we describe the mechanism.

Effect on 5-FU, to 5-FU-induced cell death. In the future, aim to improve the strategy.

Effectiveness of 5-FU is a possible target, activated by cell death and cell survival pathways.

1。Introduction to the scenic spot.

5-Fluorouracil (FU) is widely used in a variety of cancers, including:

Breast cancer and respiratory cancers of the digestive tract, but have the greatest impact on colorectal cancer.

Cancer. 5-FU-based chemotherapy improves overall and disease-free survival in patients.

Resected stage colorectal cancer (1). However, the response rate to 5-fu.

Chemotherapy as a first-line line for advanced colorectal cancer** is only 10

15% 2。With a combination of new chemotherapy drugs 5-fu, such as irinotecan and.

Oxaliplatin improves response rates by 4050% between advanced colorectal cancers (3, 4). However, despite these improvements, the new ** strategy.

Urgent need. Understanding the mechanisms and causes of cell death in 5-fu.

This becomes an important step in the fight against tumor against 5-fu resistance to overcome resistance.

This chapter discusses an important collection of 5-fuand mechanisms of action.

Determines the sensitivity of the drug, focus, in particular, in the regulation of apoptosis.

For 5-fu, we believe in a lot of future ** strategies that aim to be.

Enhances the effectiveness of 5-fu by modulating cell death and survival pathways.

Mechanism of action of fluorouracil.

5-Fluorouracil (FU) is an intracellular conversion into an active metabolite: fluorodeoxyuridine.

Monophosphate (FDUMP), fluorodeoxyuridine triphosphate (FDUTP), and.

Fluorouridine triphosphate (fluorouracil triphosphate) (see Figure 1). Interference of active metabolites of 5-fu.

Source: Apoptosis, Cell Signaling, and Molecular Mechanisms of Human Disease, Vol. 1rPublishing Company, Totowa, New Jersey.

No, unless you have time, it's time-consuming.