What are the causes of high creatinine, and what are the causes of high creatinine

A creatinine value higher than normal is called a high creatinine, which includes serum creatinine and urine creatinine, but blood creatinine is more meaningful as a measure of kidney function. Therefore, high creatinine generally refers to high blood creatinine. In general, the standard of normal serum creatinine is:

44-106 mol L, but according to the new international standard of 59-106 mol L, when the serum creatinine exceeds 106 mol L, it means that the kidneys may be damaged, and renal insufficiency and kidney failure have occurred. (Above 106 mol L is the inflammatory injury phase, 186 mol L is the renal function damage phase, and 451 mol L is the renal failure phase). Creatinine in the body is mainly produced by muscles and excreted through the kidneys.

In general, the amount of creatinine produced is constant, and the level of creatinine in the blood depends mainly on how much creatinine is excreted by the kidneys. The compensatory function of the kidneys is very strong, and if both kidneys are normal, then the blood creatinine can be maintained at a normal level as long as one kidney is functioning. In other words, kidney function must drop to half the normal level before blood creatinine rises.

Therefore, serum creatinine does not fully reflect the cause of early, mild decline in renal function.

The causes of high creatinine are divided into physiological and pathological. If the creatinine is physiologically high, it is common in some very muscular areas, such as athletes or after a lot of exercise, resulting in a transient increase in creatinine. At this time, the blood creatinine may be slightly higher than the positive range, but other kidney functions such as urine routine, urine protein quantification and other indicators are normal, so the increase in creatinine is not a big problem, and it is also considered to be normal kidney function.

The main causes of high creatinine are as follows:

1. Acute renal failure. A marked, progressive increase in serum creatinine is an indicator of organic damage and may be associated with oliguria or non-oliguria.

2. Chronic renal failure. The degree of elevation of serum creatinine is consistent with the severity of the lesion, and the serum creatinine in the compensated phase of renal failure is less than 178umol L, the blood creatinine in the decompensated phase of renal failure is greater than 178umol L, and the serum creatinine in the renal failure phase is significantly increased, which can be greater than 445umol L.

Clause. 1. For physiological reasons, creatinine is produced by muscle metabolism, and 20g of phosphocreatine will produce 1g of creatinine. If the patient exercises more or eats more meat, the production of creatinine will increase, and when the rate of creatinine production exceeds the rate of glomerular excretion, the patient will have an increase in blood creatinine.

Clause. 2. Renal insufficiency, renal insufficiency will lead to a decrease in the patient's glomerular rate filtration, at this time, creatinine can not be effectively discharged, and the blood creatinine level will also increase. There are also special cases because 85% of serum creatinine is excreted from the glomeruli and 15% is secreted from the renal tubules.

If drugs are used to inhibit the secretion of renal tubules, the patient's serum creatinine level will also be slightly elevated at this time, and the most common drug is cimemididine.