Too many platelets? What causes a high platelet count?

First of all, for platelet excess, the normal platelet value is 100 to 300 times 10 times 10 to the ninth power per liter. If we have a significant increase in platelets, it is more common in the following two diseases:

The first is primary thrombocythemia, and there is secondary thrombocythemia. In general, primary hyperplasia is mainly due to the proliferation and differentiation of aggregate cells in the bone marrow, which causes a significant increase in platelets, which is mostly much higher than normal, and is prone to various thrombotic diseases.

In the case of some underlying diseases such as hypertension, hyperlipidemia, and diabetes, thrombocytosis needs to be anticoagulated, and aspirin antiplatelet aggregation is commonly used.

Specifically, some cytotoxic drugs can also be used to reduce the platelet count, commonly used is aspirin, and then secondary thrombocythemia, which can have bleeding. Generally, bleeding can gradually return to normal after it stops, and secondly, thrombocytosis can also occur after splenectomy.

It often lasts for a long time, and can reach two to three times the normal value in a short period of time, and generally does not require special treatment. It can be carried out to promote blood circulation and remove blood stasis**, and the blood routine should be monitored regularly.

Platelet elevation is more common in hematologic disorders, after acute hemorrhage, and splenectomy. The child's platelets are only mildly high, which may be caused by a viral infection, don't worry, if there is no discomfort, you can recheck it after a week, compare the results, if the platelets continue to rise, you can further check to clarify the condition.

The causes of high platelet count can be divided into secondary thrombocytosis, spontaneous thrombocythemia and essential thrombocythemia according to their **. Secondary thrombocythemia, commonly seen in anemia or blood loss, infection, malignancy, rheumatological disorders, trauma, stress, medications, and splenectomy, can cause platelet reactivity. Spontaneous thrombocytosis occurs in some myeloproliferative neoplasms, such as primary myelofibrosis, polycythemia vera, and myelodysplastic syndromes, which can lead to thrombocytosis.

Essential thrombocythemia is a clonal disease of hematopoietic stem cells dominated by megakaryocyte hyperplasia, and the exact cause of the disease is unknown.

Essential thrombocythemia is a relatively chronic group of myeloproliferative disorders, also known as "hemorrhagic", "true" or "idiopathic" thrombocythemia. Similar to other myeloproliferative disorders, this disease is a clonal disease of pluripotent hematopoietic stem cells. It is characterized by abnormal hyperplasia of megakaryocytes in the bone marrow and markedly elevated platelet count.

The main clinical manifestations are bleeding and thrombophilia.

The incidence of the disease remains, estimated at 10 cases per million people per year, which is about 1 4 of polycythemia vera. The disease is more common in adults older than middle-aged, with occasional cases in children. Thanks to the use of automated blood analyzers, asymptomatic cases can also be diagnosed, and cases among young people are increasing.

There is no gender difference in the distribution of the disease.

The main causes of death are severe bleeding and thrombosis of vital organs. Some cases can transform into chronic myeloid leukemia, myelofibrosis, or polycythemia vera, and can turn into acute leukemia. Chemotherapy drugs, such as 32p or alkylating agents**, may increase conversion to leukemia.

Patients with essential thrombocythemia generally have a similar survival curve to the normal population of the same age after the syndrome differentiation of traditional Chinese medicine for blood circulation and stasis**, and the prognosis of general patients is good.

It depends on the specific data and why.

Thrombocytosis is divided into two categories: secondary and primary.

Secondary can**.

At present, the primary disease can only be controlled with drugs, and like hypertension and diabetes, it must be taken for life.

It is a type of myeloproliferative disease, and most patients have long-term stable disease after drug control, but some patients may have conversion.

Hello, for platelets high this.

A question you need to understand and pay attention to, about the high platelets you ask, I will answer for you: thrombocytosis When the number of platelets is 400 109 l, it is called thrombocytosis. Essential thrombocythemia is commonly found in myeloproliferative disorders such as chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, etc.

Reactive thrombocythemia is common in patients with acute and chronic inflammation, iron deficiency anemia, and tumors, and the number of platelets in this type of thrombocythemia generally does not exceed 500 109 L, and the number of platelets will decrease quickly after the improvement of the condition. Platelets rise markedly after splenectomy, often higher than 600 109 lIf an elevated platelet count is associated with certain disorders (secondary thrombocythemia),** it should be directed at the primary disorder.

If successful, the platelet count should usually fall back to normal.

The normal range in the human body (100-300)*10 to the 9th power. Its physiological functions are to stop bleeding, coagulate, repair broken blood vessels, and prevent blood outflow.

If platelets are elevated, look at the child's age of onset first. Normally, the platelet reference range is (100-300) 10 9 L, while the neonatal platelet reference range is (100-400) 10 9 L, so if it is (350-360) 10 9 L, it is higher for a normal person. It is normal for newborns.

If it is determined that her platelets are elevated, then we will look at what is the reason for his height, first of all, to determine whether it is a false positive Why is it a false positive? That is to say, he did not have an increase in platelets, but because of some other factors, such as iron deficiency anemia and thalassemia. In these patients with anemia, their red blood cells are small and can easily be mistaken for platelets, so these factors should be ruled out.

If these factors are excluded, then we have to look at his specific causes Generally speaking, there are two major types of causes of platelet elevation, the first is primary platelet elevation, and the other is secondary. If it is a primary platelet increase, it is often accompanied by an increase in the average platelet volume, a relatively large liver and spleen, and some manifestations of other diseases of the blood system, and the platelet increase will be greater than 1000 10 9 L. If it is some of the most common secondary ones, it is the common cold fever, cough, runny nose, diarrhea, diarrhea, which can also cause platelet elevation.

If it is a secondary problem, it will not be too big, as long as it is not greater than 1000 10 9 l l can be observed by follow-up method. If it is greater than 1000 10 9 l, it is required to take oral antiplatelet drugs**.

If the platelet count is a little high, don't worry.

Thrombocytosis: Thrombocytosis is common in myeloproliferative disorders, such as essential thrombocythemia, chronic myeloid leukemia, polycythemia vera, acute hemorrhage, acute hemolysis, malignant tumors, infection, hypoxia, trauma, fractures, etc. Reactive thrombocythemia is common in patients with acute and chronic inflammation, iron deficiency anemia and cancer, and such increases generally do not exceed 500 109 L.

Platelets are markedly elevated after splenectomy, often above 600 x 109 L, and then slowly fall back to the normal range.

Your platelets are high, but many conditions can be caused, physiological normal people generally have a 6%-10% change in a day, lower in the morning, slightly higher in the afternoon, lower in the spring, slightly higher in winter, higher in highland areas, higher after menstruation, and higher after exercise. Pathological myeloproliferative diseases, essential thrombocythemia, acute hemolysis, acute suppuration** infection, you pay attention to observation first, and then check in turn after a while, if it is still high, then find out how it is caused. An inflammatory response to one inflammatory factor can lead to an increase in platelets, while all other values are normal.

The normal platelet content of a person is 100-30010 9 L, which is slightly higher than the normal value, and if the other values are normal and there are no symptoms, there is generally no problem. It's just that platelets are involved in blood clotting, so higher values increase the likelihood of thrombosis. Thrombocytosis:

When 400x109 l is thrombocytosis, essential thrombocythemia is common in myeloproliferative diseases, such as chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, etc.; Reactive thrombocythemia is common in patients with acute and chronic inflammation, iron deficiency anemia and cancer, and such increases generally do not exceed 500 109 L.

If it is still so high (more than 400 is meaningful, although the upper limit of reference provided by some laboratories is 300), it is necessary to pay attention to whether there are blood diseases, such as myelofibrosis, thrombocythemia, polycythemia vera (this case is not), etc.

Seek medical attention in time and be active to prevent blood clots.

Depending on how much, if it is serious, take medicine, as long as it can play an anticoagulant role.

If you want to have a better platelet increase, you must first understand the reasons for the high number of platelets, the causes, so as to achieve the best results, and choose the best medical institutions.

You can follow a few of them to understand and understand I hope it can help you.

Personal advice, for your reference only Health Ping An * Ping An Health

1. How much higher? If it is a little higher, it can also be considered as a normal range, because there is a certain error in medical tests.

2. If it is much higher than the normal value, and Panax notoginseng powder has a good hemostatic effect, it can significantly shorten the bleeding and coagulation time, so don't eat it first.

3. And what kind of disease do you eat it for? Why did you go for a blood test?

4. Therefore, you should consult your doctor in detail to understand if there are any other diseases or other symptoms? Only the right symptoms can be prescribed.

Summary: Just from your question, it is personally recommended not to eat it at first.

Personal advice, for your reference only Health Ping An * Ping An Health

At present, the blood routine shows that the hemoglobin is slightly low, the platelets are slightly high, there should be no major problems, it is recommended to recheck the blood routine after a week, and the diet can eat some red dates, peanuts, etc.

Generally speaking, routine blood tests mainly look at red blood cell count, hemoglobin content, white blood cell count and platelet count. If the platelet count is relatively low, it means that the coagulation function is relatively poor, and the number of platelets is high, which has no effect on the body, and may be related to the precision of the instrument and not drinking water.

There is no direct relationship between colds and platelet levels.

If the platelet count is high or caused by hemoconcentration, do you have a blood test when you have a fever?

The normal range of platelet count is 100-300, check it yourself, if it is high, wait for your fever to subside, cold after the recheck, see how it is?

If it is also high, a blood viscosity test should be done if necessary.

--[The causes of the disease are common in the following three situations].

1.Reactive thrombocytosis.

Seen in infection, postoperatively, malignancy, postsplenectomy, acute blood loss or iron deficiency, trauma, noninfectious inflammation, etc., these ** lead to increased release of platelet growth factors (eg, thrombopoietin, interleukin-6), resulting in thrombocytosis.

2.Spontaneous thrombocytosis.

It is seen in myeloproliferative diseases, such as polycythemia vera, early myelofibrosis, chronic myeloid leukemia, etc.

3.Essential thrombocythemia.

The pathogenesis may be related to thrombopoietin and thrombopoietin receptor alterations and downstream pathway activation. Fifty percent of patients with essential thrombocythemia had a mutation in the JAK2V617F gene, 3% of patients had a mutation in the MPL gene, and 15% of patients with 25% had a mutation in the Calr gene.

[The specific clinical manifestations are as follows].

1 Complete blood count.

Platelet count is 450 109 L, usually in (600 3000) 109 L, and smear shows stacks of platelets, occasionally large, deformed, or small platelets. Leukocytes may be increased, (10 30) 109 L, and the classification is dominated by neutrophoblastic nuclear granulocytes.

2 Bone marrow** cytology.

Nucleated cells are active or markedly active, with megakaryocyte hyperplasia being particularly pronounced, characterized by a large mature megakaryocyte increase with a large platelet aggregation.

3. Platelet and coagulation function measurements.

Platelet function was often abnormal, and the aggregation response of platelets to collagen, ADP, and arachidonic acid induced decreased in the aggregation test. The bleeding time may be prolonged, the prothrombin depletion time may be shortened, and the blood clot may not regress well.

4 Gene mutation testing.

Mutations in the JAK2V617F gene were found in 50% of patients, MPL mutations in 3% and 5% of patients, and CARs mutations in 15% and 25% of patients.

[The usual ** method is as follows].

1.Reactive thrombocytosis.

Active**Primary disease, after the primary disease is controlled, platelets gradually return to normal count.

2 Essential thrombocythemia.

There is currently a lack of specific methods for this disease, with the aim of reducing the number of platelets, prognostic thrombosis and hemorrhage, and reducing disease progression. **Regimens are graded according to the risk of thrombotic complications in patients with ET.

1) Screening for hypertension, hyperlipidemia, diabetes and smoking history, and corresponding **.

2) Unless contraindicated, all patients with ET are given aspirin**.

3) Patients in the high-risk thrombosis group underwent cytoreduction**, ** drugs include hydroxyurea, anagrelide, interferon, etc.