What is Mandatory Spondylitis What is Mandatory Spondylitis?

Hello, ankylosing spondylitis (AS) is a disease in which inflammation of the sacroiliac joints and spinal entheses is the main symptom. Involving the sacroiliac joint, causing spinal rigidity and fibrosis, resulting in different degrees of eye, lung, muscle, and bone lesions, it is an autoimmune disease. If the disease is not treated in time, it will eventually lead to damage to the spine, joints, and even disability.

The symptoms of the disease vary in different patients, and ankylosis not only invades the spine joints, axial joints, and major joints of the limbs, but also affects the function of the patient's various organs. Patients with ankylosis are not only weaker than ordinary people in terms of mobility, but also a little worse in terms of physical fitness and physical strength.

Ankylosing spondylitis, often referred to by patients as immortal cancer or living mummy, is a chronic progressive systemic inflammatory disease that mainly invades axial joints, such as the sacroiliac joints, hip joints and spine, and the typical clinical manifestation is inflammatory back pain. Inflammatory back pain usually occurs at rest or at night, gets worse in the morning, but is relieved by activity, and usually occurs in young men. In addition to inflammatory back pain, ankylosing spondylitis also manifests as some asymmetric peripheral arthritis, tendon and ligament enthesitis, and iridocyclitis, which are some of the problems of eye inflammation.

In advanced stages, ankylosing spondylitis presents with some stiffness and stiffness of the spine, which eventually leads to severe impairment of spinal function and a severe reduction in quality of life. The prevalence in our country is the onset of the disease, usually between 10-40 years old, the peak is 20-30 years old male patients, after the age of 40 or before the age of 8 years is rare, the ratio of male to female patients is generally 3:1, more men than women, male disease is generally more serious than women.

Current studies have found that it is mainly genetics and environment that play a very important role in the onset of ankylosing spondylitis, for example, the leukocyte antigen called hlab27 that patients often check is very closely related to the onset of ankylosing spondylitis, and ankylosing spondylitis also has an obvious familial tendency, and the heritability rate of ankylosing spondylitis in identical twins can be as high as 97%. More than 95% of patients with ankylosing spondylitis carry the HBA27 gene, so ankylosing spondylitis is a disease mainly affected by chronic inflammation of the spine itself and accessory tissues, but it can also involve peripheral joints, and chronic diseases of internal organs or other tissues can occur, which will seriously affect the life of patients. If you find this kind of inflammatory low back pain and the age of onset is between 20 and 40 years old, it is best to go to the hospital in time to better control the disease and prevent disability.

Ankylosing spondylitis is a chronic inflammatory disease, mainly invading the sacroiliac joints, spine bony prominences and other symptoms.

Ankylosing spondylitis is a hidden, erosive, and destructive autoimmune disease, with the onset of young adults and a high incidence of 15 to 30 years old.

Ankylosing spondylitis is a chronic disease with the spine as the main lesion, which is caused by the combined action of various factors such as genetics and environment, mainly involving the spine and sacroiliac joints, causing spinal rigidity, difficulty in moving, and varying degrees of damage to multiple organs such as eyes, lungs, cardiovascular, and kidneys. Ankylosing spondylitis can be performed by medication, surgery, physical methods**, but not yet**, and requires lifelong intermittent**.

The harms of ankylosing spondylitis include: 1. Deforming the spine, causing the sacroiliac joint and hip joint to collapse, affecting the normal activities of the human body; 2. Involve the joints of the lower limbs, such as knee joints and ankle joints, resulting in inconvenience; 3. Involve the thoracic cage, causing dyspnea; 4. Involve the eyes, resulting in blindness; 5. Involve the intestines and cause ulcerative colitis and other diseases. Some patients may present with mild systemic symptoms in the early stages, such as fatigue, weight loss, long-term or intermittent low-grade fever, and mild anemia.

Due to the mild disease, most patients cannot be detected early, and in severe cases, there will be bamboo-like changes in the spine, hunchback deformity, and the pain will gradually increase.

Ankylosing spondylitis is a disease caused by an autoimmune disorder. The patient's immune disorder causes the body's immune system to treat HLA-B27 as a foreign invader, resulting in aseptic inflammation latent in the patient's body, traveling with blood circulation throughout the body, and aseptic inflammation attaches to the synovium, ligaments, and joint cavity of the patient's joints, eroding the tissue components of the joints in the patient's body. In the early stage of the disease, aseptic inflammation erodes the patient's joints, and the joints are edemaous and congested, and the patients only feel pain and swelling in the joints.

If the patient's friend fails to control the development of the disease in time after the onset of antonia, resulting in the continuous deterioration of the ankylosis condition, then, with the repeated erosion of the patient's joint by aseptic inflammation, adhesion and fusion appear at the joint, calcification points and soft tissue calcification appear in the joint, and then hyperplasia and osteophytes occur, and then continue to develop bone bridges and bamboo-like lesions, and the spine bamboo-like lesions develop upward, and the patient's spine will appear deformed and hunchbacked.

The English name of mandatory spondylitis is "ankylosing spondylitis", abbreviated as "AS".

Hello, ankylosing spondylitis is hereditary, but also affected by the environment, emotions, etc., immune system disorders lead to aseptic inflammation invades the joints and kidneys.

Hello, the symptoms of ankylosing spondylitis are as follows:

1.Lumbosacral pain occurs suddenly, is severe and immobile, or is accompanied by fever, resembles mechanical flank pain or acute inflammatory changes, and may be relieved or disappear after a few days of bed rest. The initial pain is usually located in the lumbosacral region, which can be unilateral, and then gradually progresses to bilateral, and when the pain is severe, it can radiate to the iliac crest, pubic symphysis, double rat stream, ischial tuberosity and the back of the thigh, and the traction of coughing, sneezing, and bending over can make the pain aggravate suddenly.

2.Patients with ankylosing spondylitis often feel stiff and uncomfortable in the lumbosacral region when they get up in the morning, or when they stand up after lying and sitting for a long time, and sometimes they need to hold objects to move with strength, and after a period of activity, this stiffness will gradually reduce, relieve or disappear. Mild cases last for a short period of time, and severe cases can last all day.

3.The characteristic pathological change of ankylosing spondylitis is inflammation of the enthesis. An attachment point is where muscles, ligaments, and bones or joint capsules are attached.

Enthesis inflammation is nonbacterial inflammation of the tendon ends. Enthesis lesions may be found in cartilage or biverted joints, especially in less mobile joints such as the sacroiliac joints and the articular processes of the spine. Inflammation of the enthesis in many areas can cause clinical symptoms.

Hope it helps.

In the early stage of ankylosing spondylitis, the main manifestations are low back pain or sacroiliac discomfort, pain or stiffness, when getting up in the morning or sitting for a long time, the stiffness of the waist is obvious, but it is reduced after activity, and it can also be manifested as soreness or discomfort in the groin of the buttocks The symptoms can be radiated to the lower limbs, and a few are the first to have neck and chest pain, and the symptoms are aggravated when they are resting and relieved after activity. Half of the patients have inflammation of the large joints of the lower limbs, such as hip, knee and ankle joints, as the first symptom, which is often asymmetrical, and the reverse action is relieved. Late-stage spinal stiffness can lead to flexion of the trunk and hips, and eventually hunchback deformity.

In severe cases, rigidity can be greater than 90 degrees of flexion, unable to see at eye level, the field of vision is limited to the foot, the thoracic spine is kyphosis stiff, and the head is deformity.