What biologics are used to treat mandatory spondylitis and what drugs are being taken. It s urgent

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What patients are candidates for biologics**?

Clinical observation believes that the condition is very active, such as patients with severe pain, severe eye inflammation, blood tests show that inflammatory indicators (such as erythrocyte sedimentation rate, C-reactive protein) are significantly elevated, and patients with axial joint involvement (such as hip joint lesions) have a better effect. In addition, if conventional medications** are not effective, biologics may also be considered.

Ankylosing spondylitis, especially the axial type, there are not many drugs with definite efficacy, biological agents are new drugs that have emerged in recent years, and there are currently two main biological agents in China - tumor necrosis factor (TNF)-A antagonists, which can be used for ankylosing spondylitis.

Etanercept (domestic trade name: YISAIPU) is a soluble TNF-A receptor fusion protein, which binds to TNF-A in the human body with high affinity, so that the biological activity of TNF-A is lost, so as to achieve the first purpose. However, because TNF-A is an important component of the body's natural immune response, excessive inhibition can cause immune deficits in the human body, resulting in adverse reactions such as infusion reactions, heart failure, lupus-like syndrome, and increased prevalence of infections and tumors.

Of course, there is another very important aspect of ankylosing spondylitis, which is to develop good daily habits and strengthen exercise. Patients should usually sleep on a hard bed, sleep on their back, and take a hot bath. Exercises that can be helpful include swimming (be sure to be safe), gymnastics, running, etc.

If the spine is fused or there is osteoporosis, you should avoid exercising too much; When the joints are deformed and cannot move freely, the muscles should be massaged frequently to avoid muscle atrophy.

Early, active, rational and safe use of liquid knives and drugs** is the key to controlling the condition of AS and reducing disability, commonly used drugs: a non-steroidal drugs: they can quickly improve the patient's low back stiffness, reduce joint swelling and pain, and increase the range of motion, there are many kinds of such drugs, which need to be used under the guidance of a specialist.

B course improvement drug: it can significantly control the development of AS and prevent joint destruction, and is the main drug of **AS, commonly used sulfasalazine and methotrexate thalidomide.

Since the effect of simple drugs on local diseased joints is not very obvious, it is actively used for local diseased joints with non-invasive interventional synovolysis**, combined with drugs to regulate immune function as a whole, which can well control the disease, prevent further deformation and disability of joints, and reduce and eliminate pain and swelling to achieve clinical results.

c Biologics: YISAIPU, etc. These biologics are recommended to be used when conventional ** is ineffective, but they are expensive and not affordable for the general public. And so far, the efficacy and many *** are not very clear.

D Glucocorticoids: Only when AS patients have severe arthritis symptoms, obvious joint effusion, as well as internal organ involvement, severe vasculitis and other critical phenomena, should consider the use of corticosteroids, but should be in small doses, the course of treatment should not be long, once effective, withdraw as soon as possible.

Nonsteroidal anti-inflammatory and analgesic drugs.

These drugs are the most widely used because they have a quick onset of action and can control pain in a shorter period of time. Commonly used varieties are sodium diazophenolate, sulindalic acid, ibuprofen, etc., and their common *** is the adverse reaction of the digestive tract. Pre-pro-selective cyclooxygenase inhibitors have a high safety profile for the digestive tract.

Chronic acting drugs.

Commonly used bipaipure sulfasalazine, methotrexate, etc. These drugs have a slow onset of action and take about 3 months to take effect. The use of these drugs can slow or stop the progression of the disease, but it is more common and must be used under the guidance of a doctor.

For those who are allergic to sulfonamides, sulfasalazine is contraindicated.

Proprietary chinese medicines. Chinese medicine considers ankylosing spondylitis to be a paralytic disease, and after the disease is controlled and stabilized, patients can choose to use proprietary Chinese medicines to consolidate the curative effect.

Ankylosing spondylitis, no matter what method is used, the effect is relatively slow. Traditional Chinese medicine believes that the internal cause of ankylosing spondylitis is the deficiency of the kidney and the pulse, and the external cause is the wind and cold, which can be treated with food.

1. Hot and spicy food: The diet of ankylosing spondylitis needs to be able to resist rheumatism and dispel cold evils, such as chili pepper, green onion, Sichuan pepper, large material, fennel, garlic have the effects of sterilization and antiviral, which can prevent intestinal infections and viral infections.

2. Beans: soybeans, black beans, soybeans, etc., are rich in vegetable protein and trace elements, which have the effect of promoting the metabolism of muscles, bones, joints and tendons and helping to repair lesions.

3. Fruit food: chestnuts have the effect of tonifying the kidneys, strengthening the muscles and bones, and the finger slip is extremely beneficial to the muscles and bones, meridians, rheumatism and paralysis, waist and knee weakness. Ankylosing spondylitis is a disease of muscles, bones, muscles and joints caused by kidney deficiency.