What causes drug induced deafness?

Drug-induced deafness refers to deafness or vestibular dysfunction caused by ototoxic drugs that can cause damage to the cochlea or vestibule.

In other words, deafness caused by the use of certain drugs or exposure to certain chemical agents.

More than 100 kinds of ototoxic drugs have been discovered, mainly including aminoside antibiotics, antimalarial drugs, analgesics, diuretics, anesthetics, anticonvulsants, anti-inflammatory drugs, anticancer drugs, anti-tuberculosis drugs, cardiovascular drugs, contraceptives, arsenic, mercury and other products. Among them, the misuse or abuse of antibiotics (aminoglycosides) is the most important and common cause of drug-induced deafness.

The causes of drug-induced deafness can be divided into two main categories, one is called hereditary congenital deafness, which is a hearing impairment caused by genetic defects such as genetic or chromosomal abnormalities, and is mostly sensorineural hearing loss. Through epidemiological investigation and research on the deaf population in China, the relationship between mitochondrial DNA, gene mutations and drug-induced deafness has been widely recognized among the genes associated with hereditary deafness.

Secondly, there is a kind of non-hereditary congenital deafness, which can be used inappropriately by the mother during pregnancy, often referring to some ototoxic drugs, such as amino sugars, glycosides, cytotoxic drugs, antimalarial drugs, chemotherapy drugs, diuretics, etc., these drugs enter the fetus through the placenta, resulting in fetal poisoning and inducing deafness. In addition, deep anesthesia during pregnancy can also cause hearing damage to the fetus.

Drug-induced deafness. The main reason is that when the patient is exposed to anti-tuberculosis and antibacterial ototoxic drugs, the drug has the ability to damage the auditory nerve, which then leads to the degeneration and atrophy of the auditory nerve, so that the patient has severe hearing loss, tinnitus and vertigo. Therefore, in daily life, we must actively avoid contact with ototoxic drugs, because there is no special effect after deafness caused by ototoxic drugs**.

Ototoxic drugs include streptomycin, gentamicin sulfate, erythromycin and memanmycin.

First, ototoxic drugs, especially aminoglycoside antibiotics, should not be used if they can be used, and drugs with less ototoxicity and good effect should be selected if they must be used. Use the smallest effective dose to keep the duration of administration as short as possible.

Second, before taking the drug, you should read the drug instructions carefully, strictly grasp the indications for drug use, and choose the right drug to do the right medicine.

Third, the elderly, young children, people with liver and kidney insufficiency, and those with pre-existing hearing impairment should reduce the dose or extend the interval. Ototoxic drugs should be contraindicated in pregnant women.

Fourth, some ototoxic drugs aggravate the toxic effect when they are used together, which will aggravate the damage to the auditory nerve, so the use of more than two ototoxic drugs should be avoided as much as possible.

The most common antipyretic analgesic that can cause deafness is aspirin, which can cause bilateral, symmetrical hearing loss of up to 40 decibels, and the damage is reversible, and can also leave severe tinnitus and permanent hearing loss. In addition, commonly used clinical sedative-hypnotic drugs such as phenobarbital, heavy metal preparations such as arsenic, lead, mercury, etc., and contraceptives such as naproxen can also cause deafness.

In severe cases, there may also be unsteady standing or gait, and uncoordinated movements of the limbs on both sides. Generally, after stopping the drug, the hearing in both ears begins to decline symmetrically for a few months or even years. It can also occur during medication and eventually lead to deafness.

Drug-induced deafness, as the name suggests, is hearing loss caused by medication.

Drug-induced hearing loss, also known as drug-induced hearing loss or drug-induced hearing loss, refers to hearing loss due to the use of certain medications. These drugs are called "ototoxic drugs", and they have a direct damaging effect on the structure or function of the inner ear, leading to hearing loss and even complete deafness.

Ototoxic drugs include certain antibiotics (such as aminoglycoside antibiotics such as gentamicin, streptomycin, kanamycin, etc.), certain antineoplastic drugs (such as cisplatin), certain diuretics (such as furosemide), nonsteroidal anti-inflammatory drugs, etc.

Symptoms of drug-induced hearing loss may include hearing loss, tinnitus, vertigo, etc. As soon as these symptoms appear, the medication should be stopped immediately and medical attention should be sought to prevent further hearing loss.

The key to preventing drug-induced deafness is to use drugs rationally and avoid unnecessary use of ototoxic drug arubium. For cases where it must be used, it should be used under the guidance of a doctor and regular hearing check-ups.

Drug-induced deafness is deafness caused by the use of certain medications or exposure to certain chemical agents.

Drug-induced hearing loss is hearing loss due to allergies to certain medications.

At present, there are many kinds of deafness (especially deaf-mute), among which drug poisoning accounts for more than 60% of deafness. Drug-toxic deafness (referred to as drug-induced deafness) is deafness caused by the use of certain drugs or exposure to certain chemical agents. Drugs that can damage a person's hearing are called ototoxic drugs, and these drugs mainly damage the inner ear, thus affecting two important functions of the ear:

Balance & Hearing. Chronic poisoning caused by ototoxic drugs is characterized by deafness, tinnitus, and even complete hearing loss in a small number of patients. At present, nearly 100 kinds of ototoxic drugs have been discovered, among which aminoglycoside antibiotics cause deafness, including kanamycin, gentamicin, streptomycin, chloramphenicol, neomycin, erythromycin, etc., among which neomycin is the most toxic.

Because these antibiotics do not require skin testing and are inexpensive, they are widely used in rural areas, especially in children. In addition, there are some drugs that are prone to ototoxicity: diuretics, antimalarial drugs (such as quinine and chloroquine), preparations containing heavy metals (such as preparations containing lead, arsenic, mercury, etc.), anticancer drugs, antipyretic analgesics (such as aspirin), ** arrhythmia and hypertension drugs (such as propranolol, cardiolenide, etc.), certain contraceptives, disinfectants (such as iodine, chlorhexidine, formaldehyde).

Because the deafness caused by ototoxic drugs is caused by direct damage to the sensory nerve cells of the inner ear, and it is difficult for the body's nerve cells to regenerate once they die, so far there is no way to find such a hearing disorder. For drug-toxic deafness, timely detection, early diagnosis and early intervention should be achieved. To avoid drug-induced deafness, precautions should be taken aggressively.

Drug-induced deafness is damage to the hair cells of the inner ear, i.e., damage to hearing cells, caused by oral medications, resulting in deafness. If tinnitus symptoms occur after using drugs, such as ear discomfort and mild hearing loss, it is necessary to intervene in a timely manner and with good results. However, if drug-induced deafness is too long or there is degeneration and necrosis of auditory cells, it is meaningless, the effect is poor, and the prognosis is poor.

Hello, the symptoms of drug-induced deafness include headache, dizziness, deafness, and when the auditory nerve damage is first caused after taking ototoxic drugs, there may be symptoms of headache, dizziness, tinnitus, and buzzing in the ears, which is generally bilateral. Hearing loss, deafness? Symptoms such as headaches, dizziness, and tinnitus often occur, and hearing loss occurs, starting with hearing loss only for high-frequency sounds, and gradually for low-frequency sounds.

Hearing loss and deafness can occur during the medication. Vertigo and vertigo are more serious than ordinary dizziness, and they make people feel like the world is spinning.

Many people's deafness is caused by drugs, and there are many drugs that cause deafness, called ototoxic drugs.

In the early days, one of the common fame was aminoglycosides, such as gentamicin, streptomycin, kanamycin, neomycin, etc., these drugs are rarely used now, but in that era, especially in the seventies and eighties, there were relatively few antibiotics, and many people were infected with gentamicin and streptomycin, resulting in deafness.

Another type of drug is when malaria is rampant, and some anti-malarial drugs, such as quinine, are often ototoxic.

There are also some medicines, such as salicylic acid antipyretic analgesics, which are more or less ototoxic.

In the past two years, the drugs that cause ototoxicity are often not used, and more are some chemotherapy drugs, such as cisplatin and carboplatin, which also have strong ototoxicity.

Tips: Drugs that cause deafness are called ototoxic drugs, which are commonly found in aminoglycosides, antimalarial drugs, salicylic acids, antipyretic analgesics, etc. Many years ago, due to the lack of antimicrobial drugs, many people used gentamicin, streptomycin and other aminoglycosides** to infect or quinine antimalaria, which can easily lead to deafness.

In addition, chemotherapy drugs such as cisplatin, which are more common today, can also cause deafness.