What interesting experiments can be done with mice?

The project team lasted 5 months, using a high-flow sampler in the non-industrial area of Xuhui District, Shanghai, using glass fiber filter paper to collect atmospheric fine particulate matter, and then making a particulate matter suspension, instilling the suspension into the trachea of the experimental rats, establishing a lung injury model and observing the signs, lung weight ratio, key biochemical indicators and the degree of lung injury in different control groups.

There are many experiments that can be done by mice, such as toxicology experiments and immunology experiments, most of which will choose mice, because the pharmacological metabolism of mice is similar to that of livestock, and it is economical, easy to raise, and easy to operate.

Put the mouse on the table, crawl with a yell, and the mouse crawls forward. He cut off all the feet of the rat with a knife, put it on the table, and crawled with a loud roar, but the rat did not crawl. The experiment concluded that the rats were listening to sounds with their feet.

Immunity Commodity Testing designed an experiment with a cold model in mice. Simply put, give the rat a cold shower, then a hot shower, then a cold shower, a hot shower, a cold shower.

You can use mice for grade testing experiments, and in the experiment, change the last mouse, that is, activate some of its cranial nerve cells.

The experimenters cut off the tail of a mouse rat and let it reproduce offspring, and its offspring also have a tail The experimenter cut off the tail of the second generation of rats again, let it breed offspring, and let it cycle for nine generations to see what happens.

We can use mice to do a rat utopian experiment, which is to give 4 mice nearly unlimited food to develop freely.

I've seen anti-fatigue supplements design experiments on rat swimming, which is simply divided into two groups: taking medicine and not taking medicine, and then letting the two groups of mice swim in the water to see which group floats on the water for a long time.

The genes are relatively close to people, cheap and easy to raise, small in size and easy to store, inbreeding germline is simple, temperament is gentle and easy to operate, intraperitoneal injection effect is good, and white body hair is easy to observe. Anti-lymphatic tests can be done.

I know that Chinese medicine uses mice to do experiments on dysmenorrhea, but in fact, this is what is commonly referred to as the modernization of Chinese medicine in the Chinese medicine community, which is in line with international standards. The theory of the five elements of yin and yang, and the theory of meridians, qi and blood, can also guide the health of mice.

The reason why mice are used for experiments is because the genetic sequence of mice is similar to that of humans, and the biological significance of the mice used for the experiment is greater, and the mice bred are almost completely free of individual differences, so mice are used for experiments.

After long-term selection and directional breeding, mice have formed many breed types. Generally, people divide it into two types: ordinary and common mice and special mice to meet special needs. Special mice include high-cancer mice, low-cancer mice, diabetic rats and congenital muscular dystrophy mice.

Some divide mice into inbred strains, mutant strains, outbred and hybrid groups according to different hybridization methods and genetic characteristics.

In the laboratory, mice are often used for experiments, some people may wonder why everyone uses mice, why not use other mice and gorillas, in fact, there is a reason, let's learn more about it together.

1. Mice are easy to raise

Mouse is a very good animal, small size, small footprint, do not need much space, breeding cost is relatively low, so large-scale breeding of mice for experiments.

2. Strong reproductive ability

Mice have a strong reproductive ability, they can continue to reproduce and produce, and the cost is also reduced to a certain extent.

3. Low aggressiveness

Compared to other animals, mice have relatively low attack power. During the study, many different drugs may need to be injected, and if the animal resists strongly, it may affect the operation and even harm itself.

4. Similar to human genes

The fourth and most important point is that the genes of mice and humans are extremely similar, up to 98 percent, which is a staggering number. Therefore, if the results obtained from the experiment on mice are very similar to those obtained from humans, it is also a better choice to experiment with mice.

5. The social value is not high

Mouse is not a very popular pet and cannot be eaten as food. Therefore, if a large number of mice are used for experiments, it will not affect society and will not cause much negative impact. Although some people sympathize with mice, but this is also something that can't be helped, the significance of mice to human beings is relatively large, like the study of what human aging mystery is also done in mice to do experiments.

Will the mice die after the experiment

Some people may wonder what to do with the mice after experimenting with them. In fact, the mice after the experiment will die. They may die during the experiment, and even if the experiment is successful, they will not be able to stay.

The supplies in the experiment cannot be taken out of the laboratory, although it looks a little cruel, but in order to be responsible for humans, the mice will be disposed of uniformly. For example, twisting the neck, injecting air into the blood vessels, etc.

1. The genetic sequence of mice in mice is not much different from that of humans, and some medical scientific research and clinical experiments are done with mice, among which it is very good to do genetic experiments with mice. Because of its high similarity between the whole genome and the human state, many diseases that are difficult for humans can find similar traits in mice, so as to experimentally discover the cure gene.

2. The biological significance of the experimental white mouse is greater: the cultivation method of pure-line mice has formed a fixed process after a hundred years of exploration, and the cultivated mice have almost no individual differences.

3. Sufficient quantity: many experiments require statistical analysis, which requires a certain number, and rats and mice, especially mice, can meet this requirement under artificial breeding conditions. Pure germline experiments should be carried out with strict control of the breed of experimental animals, which is easy to solve with mice.

There is also an animal level, and the mice are also mammals, except for their small size, they are not bad compared to the evolutionary level of other mammals. The small size of the body has become a favorable condition for artificial breeding and feeding.

4. In fact, many experiments use orangutans and other animals that are more similar to humans to do the best, but the use of orangutans is too expensive. And mice are cheaper and easier to get.

We often see scientists doing all kinds of experiments with mice in movies or TV series, and some people are very curious, why do scientists raise these mice to do experiments? Why not use other creatures?

In fact, it stands to reason that the guinea pig is very small and easy to raise, so it is very easy to use for experiments. And it does not take up too much space, so among all kinds of experimental animals, mice are the most suitable animals to be used for experiments. If you choose other kinds of organisms for experiments, it is likely that the location will need to be changed.

Another is that the character of the mouse is very stable, will not make some out-of-the-ordinary behavior, and the experimenter is not easy to be harmed, so among all kinds of experimental animals, the mouse has become the most suitable for experiments.

There is also a very important reason, that is, there are many key points in the genes of mice and human genes are similar, especially in terms of genetics, scientists are using this as a breakthrough to carry out relevant research, mice will also get sick, they also have some genetic terminal diseases similar to humans and all kinds of incurable diseases, so they are used to do experiments, and the experimental data obtained are also the most authentic and reliable, and they can also be directly prescribed on the mice for drug experiments.

In addition, the reproduction rate of mice is also very fast, their lifespan is generally about three years, but they can give birth to several litters per year, at least four or five mice are born every day, the laboratory specially bred mice are of greater biological significance, the differences between individuals are very small, and it is convenient to exclude variables. Scientists do not have to worry about being forced to stop experiments due to the shortage of experimental materials.

But in fact, in addition to the mice, the animal regulars used for experiments are rabbits and frogs, all of which contribute to our human medicine, and we should respect them.

Because the genes of mice are very similar to those of humans, experiments with mice can restore some of the genes of humans, so mice are used for experiments.

This is because the genetic sequence of mice is very similar to that of humans, and the behavior and physical characteristics are also very similar to those of humans. So the results are more accurate.