Is there any scientific basis for the statement that cephalosporin is paired with wine?

Now every year when I go back to my hometown for the Chinese New Year, I always have to have a drink at the class reunion. But sometimes I don't want to drink too much, and at this time everyone will say that I am driving, after all, the drunk driving investigation is so strict now, so I can't say anything about drunk driving. But if you want to escape the drinking game, in addition to drunk driving, there is another mantra that is very widespread, that is, cephalosporin with wine and go.

Many people think that this is just a mantra, but in fact, this advice really comes from the mouth of a doctor. If you don't believe it, you can go to the hospital and prescribe some medicines, as long as your medicine contains cephalosporin, as well as some anti-inflammatory drugs, antibiotics, as well as anti-hyperglycemia and ** stomach ulcer and some anticoagulants and other ingredients of these medicines. Doctors will be hospitalized and cannot drink.

You must know that with the development of our modern medicine, human beings can synthesize many pharmaceutical ingredients that are helpful to our human body through micromolecules. But at the same time, these have special drug compositions, which to some extent also limit their living environment. Because after all, it is made by human beings through years or even more than ten years of research, and it must be very different from what we produce ourselves.

In terms of adaptability, these pharmaceutical ingredients have a lot of limitations in terms of taking compared to some natural medicines, or proteases that are naturally synthesized in our body. <>

And when we drink alcohol, it will react with these drugs to cause disulfiram. This is mainly because alcohol is also produced by us humans and has a special chemical structure. When they arrive in our body and are broken down by these cells of ours, they form a new molecule.

At this point, we can think of it as a viper-like neurotoxin. It is important for our human body, so we must not drink alcohol after taking these drugs. <>

And from a medical point of view, regular drinking is actually very bad for the liver, affecting its normal metabolism, so this is why many people now have alcoholic liver. If you really want to drink a lot of alcohol, drink some milk in advance to protect your intestines.

Cephalosporin with wine, this statement must have a scientific basis, after eating cephalosporin and drinking alcohol, the most serious thing is death, because alcohol will produce acetaldehyde in the body, eating cephalosporin will cause acetaldehyde to be unable to degrade, so it will cause harm to the human body.

There is a scientific basis for the statement that cephalosporin is paired with wine. Cephalosporin and alcohol will produce a disulfiram reaction, which will cause headache, palpitations, dyspnea and other symptoms, and in severe cases, symptoms of heart failure and death.

There is a scientific basis. Cephalosporin drugs contain a methiotetrazole side chain similar to disulfiram, which can inhibit the activity of acetaldehyde dehydrogenase, resulting in the inability of acetaldehyde in alcohol to be metabolized, followed by chest tightness, shortness of breath, weakness of limbs, dyspnea and other symptoms, and even life-threatening.

The statement that cephalosporin is paired with wine, and there is a scientific basis for saying that you can go. If you take a medicine like cephalosporin and drink alcohol at the same time, you may experience a series of symptoms such as headache and difficulty breathing. It is very harmful to the body.

Cephalosporin is wine, and the next sentence is "dumplings are wine, the more you drink, the more you have", which is an Internet buzzword.

Internet language refers to a language that is generated from the network or applied to network communication, including Chinese and English letters, punctuation, symbols, pinyin, icons (**) and words.

This combination often expresses a special meaning in the communication of specific network media. At the beginning of the 90s of the 20th century, the methods adopted by netizens in order to improve the efficiency of online chatting or to be witty and amusing have formed a specific language over time.

In the past ten years since the beginning of the 21st century, with the innovation of Internet technology, this form of language has developed extremely rapidly in the communication of Internet media.

At present, the language of the Internet has become an indispensable part of people's online life more and more. However, it should be noted that some online languages do not conform to the grammar rules of our modern Chinese, so they do not have teaching significance and cannot be introduced into the teaching field.

It is now well-known common sense that it is strictly forbidden to drink alcohol during the period of taking cephalosporin anti-inflammatory drugs, and due to the different constitutions of people, in principle, there should be no alcohol intake for more than a week. There is a medical term for "disulfiram-like reaction". This reaction refers to the discomfort of alcoholIn severe cases, it can even cause shock, which can be life-threatening.

Therefore, "cephalosporin with wine is said to go" is not a joke.

Based on the "disulfiram-like reaction", we can also conclude that the following categories should not be taken with cephalosporins:

First of all, alcohol-rich agents such as cough syrup, Huoxiang Zhengqi water, compound licorice oral liquid, etc. It can be noted in the introduction of the ingredients of the drug.

Secondly, alcohol-rich food, wine-stuffed balls, wine chocolate, durian, seafood, drunk duck, canned sardines.

Third, calcium products and milk should not be eaten at the same time as cephalosporin, and there is a theory of calcium deposition.

Fourth, ethanol should not be used at the same time as cephalosporin during wound disinfection.

In addition to the above, it is recommended that patients consult their doctor in advance while taking both cephalosporin and non-cephalosporin drugs. Be aware of the contraindications to taking medications. In addition, the instructions of different types of cephalosporin drugs must also have relevant instructions for contraindications and precautionsOnce there is a "disulfiram-like reaction" in negligence, seek medical attention as soon as possible and stop taking cephalosporins

In addition to "cephalosporin with wine and go", there is also a saying that "grapefruit with blood pressure medication is dizzy".

There are yuzu ingredientsFuranocoumarins, which can inhibit the body's metabolic enzymes, and when taken at the same time as antihypertensive drugs, will cause the blood drug concentration to increase dramatically, resulting in a sudden drop in blood pressure, dizziness and severe cardiovascular and brain function.

In addition, in addition to milk, which cannot be taken with cephalosporin antimicrobials, milk and antidepressants cannot be taken together.

The monoaminooxidase inhibitor in antidepressants itself affects the metabolism of blood oxidase, and at the same time, it will cause the tyrosine component of milk to be absorbed and cannot be metabolized after taking it, resulting in a sudden increase in blood pressure and critical cardiovascular and cerebrovascular diseases.

Finally, it is necessary to explain here that the reason why cephalosporin can cause a "disulfiram-like reaction", the most sample report shows is that cephalosporins contain a "methiotetrazol" structure, which combines with ethanol (which is rich in alcohol) to inhibit the activity of acetaldehyde dehydrogenase, causing acetaldehyde to accumulate in the blood, resulting in uncomfortable symptoms in the body. According to the data, it is the cephalosporin-like drugs with this "methiotetrazole" structure that are most shown in the "disulfiram-like reaction" report. However, not all cephalosporins have a "methiotetrazol" side chain in their chemical structure.

It has also been reported that drugs that do not have a "methiotetrazol" structure and contain a "methiotriazine" structure will also combine with ethanol to produce a "disulfiram-like reaction".

SoNot only should we not drink alcohol while taking cephalosporins, but we must also strictly prohibit alcohol during taking other non-cephalosporin drugs to avoid the intake of ethanol-based foods, so as to prevent the formation of this reaction mechanism. Because it's impossible to know the chemical structure of every drug. And we can do it in the safest way:

If you don't drink alcohol, you will live longer.

White radish: It is strictly forbidden to eat with oranges, if eaten together, it may cause goiter; White radish should not be eaten with apples, pears, grapes and other fruits; White radish should not be mixed with Polygonum multiflorum and rehmannia radish; Fasting radish while taking ginseng.

Carrots: It is strictly forbidden to eat with alcohol, because carrots and alcohol will produce toxins in the liver and cause liver disease after entering the human body together; Carrots are best eaten alone or with meat, and should not be eaten with tomatoes, peppers, pomegranates, papayas, etc., because carrots contain decomposition enzymes that can deprive other fruits and vegetables of vitamins.

Sweet potato: It should not be eaten with persimmons, as eating it will form insoluble lumps, causing stomach bloating, abdominal pain, vomiting, etc., which may lead to life-threatening in severe cases.

Bamboo shoots: Bamboo shoots should not be eaten with tofu, as they are prone to stones; It should also not be eaten with sugar.

Pumpkin: Do not eat with mutton, otherwise jaundice and beriberi are prone to occur.

Celery: Do not eat with vinegar as it can damage your teeth.

Soy milk: Do not eat with spinach and milk, and avoid using soy milk to wash eggs.

Green onion: Avoid eating with bayberry and honey, otherwise chest tightness will occur, and avoid eating with jujube and rehmannia together.

Garlic: Generally, it should not be eaten with tonics, and should not be eaten with honey, Polygonum multiflori, and rehmannia radix.

Cucumber: Do not eat with peanuts, eating with the spleen.

Cephalosporin with wine is said to be gone, which means that after cephalosporin is drunk, you can no longer drink alcohol, and there are many things that cannot be eaten together, such as persimmons and crabs will be poisoned if eaten together.

Antibiotics: such as cephalosporins, metronidazole, etc., can cause disulfiram-like reactions.

Sedative hypnosis: such as phenobarbital, diazepam, etc., will cause patients to coma, shock, respiratory failure, death, etc., because alcohol will aggravate the sedative effect of sleeping pills, inhibit brain activity, cause severe drowsiness and dizziness, and increase the risk of falls, injuries and car accidents.

Hypoglycemic drugs: such as insulin, metformin, etc., may cause hypoglycemia.

If eggs are eaten with saccharin, they can be poisoned. Dog meat and mung beans can be poisoned, turtles and amaranth can be poisoned. Eating sweet potatoes with persimmons will give stones, and crabs eating with persimmons will cause diarrhea.

Onions and honey can hurt your eyes, and potatoes and bananas can cause dark spots on your face. Spinach and tofu can cause stones, crabs and oranges can cause indigestion, bananas and taro can cause bloating, crucian carp and winter melon can cause dehydration, and snails and fava beans can cause colic.

Dog meat and mung bean soup or mung bean porridge.

People often say "take medicine and don't drink alcohol, drink alcohol and don't take medicine", many medicines and alcohol taken together, will cause great harm to the human body, serious can cause shock and even death. In fact, this is attributed to a "disulfiram-like reaction", which occurs after drinking or drinking alcohol after drinking, and the symptoms generally appear within 5-30 minutes, the slowest is 4 hours, mild facial flushing and fever, headache, palpitations, chest tightness, nausea and vomiting, dizziness, increased heart rate, severe blood pressure decrease, dyspnea, chest pain, arrhythmia, loss of consciousness, heart failure, shock, and even death.

You can't do the two things you said, you have to pay more attention to it, you can check it.

Cephalosporin plus wine, just go?

Let's first understand the above-mentioned disulfiram-like reaction, disulfiram is actually a drug for alcohol withdrawal, after taking the drug, even if you drink a little alcohol, the body will also have obvious discomfort, so as to achieve the purpose of quitting alcohol.

Generally speaking, disulfiram-like reactions mainly occur after drinking alcohol or drinking alcohol after medication, and the symptoms generally appear within 5-30 minutes, no more than 4 hours at the latest, and the mild symptoms can cause facial flushing and fever, headache, palpitations, chest tightness, nausea and vomiting, dizziness and other manifestations; More severe symptoms may include chest pain, arrhythmias, heart failure, shock, and even death.

It is important to note that disulfiram is not the only one that can cause these discomforts, but many drugs can also cause it, such as cephalosporin. The main component of alcohol is ethanol, which will be decomposed into acetaldehyde after entering the body, which is toxic, and antibiotics, especially cephalosporins and metronidazoles, will lead to the accumulation of acetaldehyde in the body, causing acetaldehyde poisoning, and disulfiram-like reactions, such as rapid heartbeat, low blood pressure and other symptoms, and in severe cases, respiratory depression, acute heart failure, and the most serious consequence is death.

Therefore, cephalosporin plus wine, just go, is not a joke, everyone must understand it correctly.

What is the difference between eating cephalosporin after drinking alcohol and drinking alcohol after eating cephalosporin?

Clinically, it was found that "how long after drinking alcohol can cephalosporin be used?" And "How Long After Using Cephalosporin Can I Drink Alcohol?" "These two issues are often confused. So let's move on to the differences between these two issues.

Generally speaking, ethanol is formed by the action of ethanol dehydrogenase (which is toxic), and the acetaldehyde dehydrogenase inhibited by ethanol takes 4-5 days to recover, so for the sake of safety, it is generally recommended that people taking cephalosporins should drink alcohol after 7 days, as well as eat foods containing alcohol, such as chocolate, drunken crab, etc.

How long can you take cephalosporins after drinking depends on how long it takes for the human body to metabolize the alcohol it drinks. Suppose you drink 3 bottles of beer in a row within 1 hour, then it will take about 9 hours for the effects of alcohol on the body to completely disappear, and even for those who can drink it will take 6 to 7 hours, so it is best to take cephalosporins 7-8 hours after drinking.

There is a saying in the market that "cephalosporin is paired with wine, just go" describes a dangerous state after taking cephalosporins:If you eat cephalosporin and accidentally drink alcohol, you may die. Alcohol and cephalosporins interact to produce disulfiram-like reactions, and cephalosporins can cause acetaldehyde, an alcohol metabolite that accumulates in the body, to cause digestive, respiratory, circulatory, and neurological adverse reactions.

The main manifestations of this type of reaction are chest tightness, shortness of breath, swelling of the larynx, difficulty breathing, rapid heartbeat, drop in blood pressure, ruddy complexion, weakness of limbs, headache, nausea, and even anaphylactic shock.

2. Even if you use drugs that may cause disulfiram-like reactions, you should not drink alcohol during the medication and for one week after stopping the drug.

3. Different liquors have different effects on disulfiram-like reactions, and if you drink liquor, it is heavier than drinking beer and alcoholic beverages; At the same time, different times of taking the drug can also cause different disulfiram-like reactions, for example, drinking alcohol during medication is heavier than drinking alcohol after stopping the drug. Therefore, it is important not to drink alcohol while taking cephalosporins.