Are anti epileptic drugs Chinese and Western medicines?

Seizures are still dominated by drugs, and there are a variety of drugs on the market that inhibit seizures, but although these Western drugs are effective in inhibiting epilepsy for a long time, they also bring a lot to the patients themselves. Traditional Chinese medicine has begun to attract the attention of epilepsy patients because of its small size. Is the effect of traditional Chinese medicine really good*** small?

Although epilepsy has long been recorded in history, there is no clear evidence that traditional Chinese medicine can control epilepsy as stably as Western medicine, not to mention that long-term use of traditional Chinese medicine will also bring the danger of drug toxicity. Taking Western anti-epileptic drugs**Epilepsy is an internationally recognized standard for epilepsy.

In medicine, the emphasis on "formal medication**" is to emphasize two points: First, the drug should be selected under the guidance of regular specialists (especially neuropediatricians and neurologists in epilepsy centers). Under the guidance and follow-up of doctors, according to regular laboratory examinations, doctors can ensure the basic safety of patients' medication by adjusting the dose and adjusting the drug regimen in a timely manner.

Second, it is necessary to choose regular drugs, that is, to choose the anti-epilepsy "Western medicine" officially approved by the international (national) for production, and it is by no means a folk tradition that can "cure, cure, and not poison".

In fact, for the clinical treatment of epilepsy, it is currently recognized that the traditional medicine of the motherland may have a certain auxiliary role, but the scientific means are to rely on regular pharmaceutical companies and international standard "Western medicine" anti-epileptic drugs. Blindly following the advertisement, choosing the so-called "traditional Chinese medicine, home remedies", is often illegally added to the ultra-large dose of the earliest generation, very cheap anti-epileptic drugs, stealing the pillar in order to obtain the "best effect", taking such "traditional Chinese medicine", not only may not be able to control epilepsy, it is more likely to lead to epilepsy becoming more and more difficult to treat, and even uncontrollable huge poison, bringing danger to the patient's life.

Therefore, it is understandable that epilepsy patients are anxious to recover, but the recovery must be achieved through a formal program and reasonable medication, do not blindly believe the efficacy of various anti-epileptic drugs on the advertisement, and do not worship the magic of Chinese medicine too much.

What is the condition of the patient now.

a.Ka Oak Yan Masiping.

b.Phenytoin.

c.Valanamide.

d.Progamide.

Correct answer: carbamazepine; benzo-stimulated such as intoin; Valanamide. Promine burns rogamide.

As one of the special drugs for anxiety and incurable diseases, clopidogrel has been very short in China, which is undoubtedly unacceptable to most patients and their families. However, in general, chloroquine plays a vital role in relieving the pressure of drug use after drug development has been intensified. Through the unremitting efforts of related companies, China is currently the first batch of chloroquine drugs to be successfully marketed.

It is not surprising that people with epilepsy are no different from evangelicals, especially the effects of generalized complex epilepsy and Romance syndrome are more pronounced, which has led to a high level of attention in the pharmaceutical market, and from this point of view objectivity reflects the great potential and vast field of generic medicines.

It is no exaggeration to say that clozapine occupies a "life-saving" position in patients with epilepsy and other indications. At the moment, China is among the first chlorophyll drugs to enter the official market, and not only to make up for the shortage. At only $84 per square meter on the market, it can also alleviate the financial pressure on the patient population, and this alone is enough to prove that these drugs are anxiety disorders and intractable epilepsy in patients with boosters.

It plays an important role in the follow-up of the disease**.

In fact, many people know very little about generics, but patients with rare diseases, in the absence of drug analogues, can be very concerned about the progress of generic drug development, suggesting that it is possible to address and control local and disease by obtaining the right to produce generic drugs to meet the market demand for tremor foot, or that disease is a great help. As the name suggests, ordinary drugs are the tradition of producing targeted drugs in the following situations: in the final analysis, obtaining permission is also to allow patients to obtain the best indications in a timely manner, which is the value of ordinary drugs in the modern society.

Overall, issues such as the lack of chlorine in stockpiles and the difficulty of purchasing drugs for children with epilepsy have been repeatedly banned, thus expanding the market space for generic drug production and causing concern even at every step of progress. Patients and their families. As in China, the first chlorpromazine drugs on the official market, patients with anxiety and epilepsy, especially children with epilepsy, have difficulty obtaining drugs that can be addressed, including epilepsy fusion drugs including indicators that undoubtedly encourage the gospel.

To the question of what is the preferred drug for petit mal seizures, experts say that after an effective diagnosis, a safe, effective, inexpensive and easily available drug should be selected according to the type of seizure. Newer antiepileptic drugs such as lamotrigine, topiramate, oxcarbazepine may be used. The drugs used for grand mal seizures, complex partial seizures, absence seizures, and status epilepticus are all different.

The dose of the drug should start from the lower limit of the usual dosage and gradually increase to the point where the seizure is well controlled and there is no serious toxicity***.

The number of doses should be based on the characteristics of the drug and the characteristics of the seizure. Generally, it is not changed or intermittent at will, and the seizures are completely controlled for two to three years, and the electroencephalogram is normal, the dose can be gradually reduced and discontinued. Drug concentrations should be monitored regularly and drug doses adjusted as appropriate.

In the case of seizures, antiepileptic drugs are of particular importance. Antiepileptic drugs can eliminate or alleviate seizures in two ways, one is to affect central neurons to prevent or reduce their pathological transition discharge; The second is to increase the excitability threshold of normal brain tissue, weaken the spread of lesion excitation, and prevent epilepsy**.

Medication selection is prone to errors, leading to seizures.

1. The selection of drugs is incorrect.

Misjudgment of the type of occurrence and failure to use antiepileptic drugs. Antiepileptic drugs should be used with care and appropriateness depending on the type of seizure.

2. The dosage of the drug is inappropriate.

If the dose is too small to reach the effective therapeutic blood concentration, too large it will induce aggravation, and at least 5-6 drugs are required after oral administration to reach the steady-state blood concentration. Therefore, to determine the good efficacy of drugs, the recommended dose and main pharmacokinetic parameters of antiepileptic drugs should be fully understood.

3. Inappropriate drug matching.

There are individual differences in drug metabolism, and the combination of antiepileptic drugs (eg, carbamazepine, phenytoin, primidone, phenobarbital) with liver enzyme-inducing effects accelerates drug metabolism without reaching effective blood concentrations. Obviously, the new generation of antiepileptic drugs, less involved in the pharmacokinetic interaction of drugs. With the exception of non-aminoesters, new-generation antiepileptic drugs have little effect on the pharmacokinetics of other antiepileptic drugs, but antiepileptic drugs with hepatic enzyme-inducing effects accelerate the eradication of new-generation antiepileptic drugs (except gabapentin and vigabatrin), while valproic acid (liver enzyme inhibitors) slows the eradication of non-amithane and lamotrigine.

It should also be noted that the interaction between non-antiepileptic drugs and antiepileptic drugs, as well as the effect on the development of epilepticism. It should also be considered that the combination of antiepileptic drugs with different mechanisms of effect could theoretically expand the anticonvulsant profile of the drug.

4. Discontinuation occurs.

Regarding the timing of drug discontinuation, the general principles are: no clinical occurrence for at least 2 years, no epileptic activity on EEG; Tapering the drug gradually. In 330 patients who had not had epilepsy for at least 2 years and had been treated with monotherapy for 1 year, the rate and risk factors of epilepsy after continuous monotherapy and perhaps gradual withdrawal of monotherapy were compared and evaluated.

Hello, it is recommended to go to a large regular hospital** (such as Beijing Junhai Hospital in Beijing), the expert is regular**, guaranteed! Because the ** of the drug can only be maintained. Go can not be used all the time**. so as not to increase the condition.

Commonly used drugs include the traditional antiepileptic drugs carbamazepine (Delidol), sodium valproate (debajin), phenytoin, phenobarbital, primidone, ethosuximide, clonazepam (clonazepam), and cediapam (diazepam); New antiepileptic drugs include amexaenoic acid, lamotrigine, topiramate, gabapentin, non-amithane, oxcarbazepine, tiagabine, and zonisamide.

It is best to go to the hospital to check and ask the doctor to see the situation and dispense the medicine.

For epilepsy, choosing the right anti-epileptic drug is the key, and some types of anti-epileptic drugs commonly used in clinical practice are introduced.

1. Barbiturates: phenobarbital, deoxybarbital, methylbarbiturates, etc., mainly exert anticonvulsant effect by increasing inhibitory chloride influx through the central inhibitory neurotransmitter R-aminobutyric acid receptor, and are also sodium channel blockers used in tonic-clonic seizures, partial seizures, neonatal epilepsy, and status epilepticus.

2. Acepropionylurea: phenytoin, methyltoin, ethoxyin, etc. Among them, phenytoin is represented, and the main mechanism of action is sodium channel blocker, which blocks repeated neuronal firing and reduces post-tonic potential.

Indicated for tonic-clonic seizures and partial seizures, but can exacerbate absence seizures. The intravenous dosage form is used for status epilepticus. However, due to the narrow antiepileptic spectrum, similar amount of ** and toxic amount, great impact on cognition, obvious drug interaction, and teratogenic effect on the fetus, the use of phenytoin sodium has gradually decreased in recent years.

3. Double-chain fatty acids: sodium valproate, magnesium valproate, epilepsy, etc. Valproic acid has multiple antiepileptic mechanisms of action, which are effective for various types of primary generalized seizures, such as tonic-clonus, absence of attention, atonic loss, and myoclonus; It is effective for partial seizures and can be used to prevent febrile seizures.

The venous form can be used for the treatment of status epilepticus. The advantages of sodium valproate are that it has a wide anti-epileptic spectrum, is effective against various types of epilepsy, has few allergic reactions, has little impact on cognition, and has no liver enzyme induction. The disadvantage is that female patients may have menstrual disorders and polycystic ovaries after use, and the teratogenic effect is obvious.

4. Succinimides: ethosuximide, methylsuccimide, etc. It is mainly used for absence seizures, and is less effective for other types of epilepsy.

5. Benzodiazepines: diazepam, nitrazepam, clonazepam, cllorazepam, etc. Clonazepam is mainly used as an adjunct to infantile spasms, myoclonic seizures, atonic seizures, and atypical absence seizures**.

6. Iminoglycins: carbamazepine, oxcarbazepine. The main mechanism of action is to block sodium ion channels, inhibit neuronal firing, and stabilize cell membranes, thereby exerting antiepileptic effects.

Indications: For partial seizures, including simple partial seizures and complex partial seizures; Partial seizures are secondary to tonic-clonic seizures. May exacerbate myoclonic seizures and atypical absences.

Common adverse reactions include rash (5% to 15%), leukopenia, and hyponatremia. The teratogenicity is less than that of phenytoin and valproate.

7. Sulfonamides: acetazolamide, zonisamide, etc. 、

8. New antiepileptic drugs: oxcarbazepine, lamotrigine, topiramate, levetiracetam.

At present, there are dozens of anti-epileptic drugs, the common phenytoin, carbamazepine, valproate sodium and so on belong to the traditional antiepileptic drugs, while lamotrigine, levetiracetam, oxcarbazepine, topiramate and so on are new antiepileptic drugs, there are still many new drugs under research, is expected to gradually promote clinical application.

At present, it is advocated to use a drug, and the commonly used drugs are carbamazepine, oxcarbazepine, sodium valproate, lamotrigine, capland, etc., but it is recommended that you go to the hospital for a check-up, and it will be safe to take medicine according to the condition, as far as I know, Zhengzhou Junhai Hospital is not bad.

Traditional Chinese medicine**Epilepsy has a fast effect and exact efficacy, it is recommended that you use traditional Chinese medicine gastrodia, amber, antelope horn, musk, bupleurum, cinnamon branch, calamus, green yang ginseng, white silkworm, hook vine, sheep epilepsy grass, mother-of-pearl, iron gall powder, halberd grass, licorice**, generally need 1-6 courses of treatment**, the active ingredients of these drugs are easy to penetrate the blood-brain barrier, directly hit the core tissue of the lesion, inhibit the abnormal discharge of brain tissue cells, quickly compete with neuromesenchymal receptors to inhibit, and repair damaged brain nerve cells. Fundamentally, seizures are a stubborn disease.

Individualized dose: Start with a small dose and gradually increase and adjust the dose according to efficacy, patient compliance, and blood concentration until maximum efficacy or blood concentration is reached. Generally, after 5 half-lives, the drug can reach the steady-state blood concentration of the drug.

Early**: Repeated seizures will lead to new brain damage, and early regular** people have a high success rate. However, if the first episode is mild and there are no other concomitant manifestations of brain injury, the drug can be reused after the second episode.

Choice of monotherapy or combination: seizures can be controlled with only one antiepileptic drug in nearly 3 to 4 cases. However, after 2 3 drugs are reasonably ineffective, especially for children with multiple seizure types, a combination of 2-3 drugs with complementary mechanisms of action should be considered.