What drugs are ototoxic? What are the ototoxic drugs?

1: Aminoglycoside antibiotics, such as streptomycin, gentamicin, kanamycin, dihydrostreptomycin, neomycin, tobramycin, netimicin, amikacin, amikamycin.

2: Certain non-aminoglycoside antibiotics, such as macrolide antibiotics (such as erythromycin, azithromycin, clarithromycin), polymyxin, vancomycin and vancomycin equivalents.

3: Chemotherapy drugs, such as cisplatin, carboplatin, nitrogen mustard, periwinkle alkaloids.

4: Quinine. 5: Salicylic acid, the most commonly used is a drug in the form of acetylsalicylic acid, that is, aspirin.

6: Non-steroidal anti-inflammatory drugs, commonly used such as ibuprofen, naproxen, indomethacin.

7: Loop diuretics, such as diuretic acid, bumetanide, pyrrotanil, furosemide.

8: Heavy metals, long-term exposure to certain heavy metals can damage the inner ear, such as lead, mercury, arsenic.

Answer]: A This question examines the toxic and side-effect of drugs. Gentamicin belongs to the aminoglycoside class of antibiotics, which is ototoxic and nephrotoxic.

Tetracycline has an effect on the development of teeth and bones in the Woodland. Chloramphenicol has a myelosuppressive effect and can cause gray baby syndrome. Penicillin and dafcillin tend to cause allergic reactions.

So the answer is a.

Answer] :d aminoglycoside antibiotic anectoidin may cause toxicity in vestibular branches, cochlea and kidney, but there are also differences in the toxicity caused by each drug, so it is necessary to accurately control the blood concentration to reduce the toxicity.

Improper use of drugs can cause deafness due to ear toxicity, such as streptomycin and gentamicin in antibiotics, but many non-antibiotic drugs can also cause deafness due to ototoxicity.

Antibiotics. For example, aminoglycoside antibiotics such as streptomycin and gentamicin can cause deafness.

Diuretics: diuretic acid, furosemide, butylaniline, etc., ear damage can occur when used in larger doses. Among them, furosemide has more insidious damage to hearing, and timely discontinuation of the drug may be recovered.

Receptor blockers: Receptor blockers such as cardiorelent, propranol, chlorthalidone, medoxinol, hydralazine and other receptor blockers are also deaf.

Salicylic acid drugs:

When aspirin is used to 6-8 grams per day, it can produce headaches, dizziness, tinnitus, deafness and other poisons***. Most patients have symptoms.

It gradually disappears in 48 hours, and a small amount of damage cannot be recovered.

Antimalarials: quinine can cause tinnitus, hard of hearing and other reactions at the first dose, and large doses may cause deafness, and it is a permanent damage that will not recover. Long-term and heavy use of chloroquine can cause permanent deafness.

Anticancer drugs: deafness is mostly reversible damage, and it can gradually recover after stopping the drug. Nitrogen mustard is neurotoxic, and high doses can damage inner ear cells, resulting in sensorineural deafness. Cisplatin in high doses can cause sudden deafness.

The early symptoms of poisoning should be found in time when using ototoxic drugs, and the drug should be stopped in time if there are high-pitched tinnitus, ear swelling, deafness, dizziness, nausea, and unstable gait during the medication. As soon as someone uses a drug to develop ototoxicity, the family member should contraindicate the use of the drug.

At present, there are more than 100 kinds of ototoxic drugs that have been discovered, and the common ones are the following categories: the first class is antibiotics, such as gentamicin, kanamycin, neomycin and streptomycin, erythromycin, chloramphenicol, tetracycline, etc.; the second category is diuretics; the third category is antineoplastic drugs; The fourth category is antipyretic analgesics (e.g., aspirin); The fifth category is antimalarial drugs.

The most common drugs are aminoglycoside antibiotics such as streptomycin, gentamicin, kanamycin, noromycin, etc., according to relevant data, 1% of short-term users have deafness, and long-term use has 30% 70% of patients have deafness. Some doctors do not calculate the dosage by weight, which is the main cause of drug-induced deafness in infants and young children. Patients with kidney disease and the elderly have low renal function, which affects the excretion of aminoglycoside antibiotics from the body, and the concentration of drugs in the blood increases, which is also prone to drug-induced deafness.

Aminoside antibiotic-induced deafness is characterized by a late onset, which often occurs weeks or months after administration of the drug. Therefore, as early as 1999, the Department of Medical Administration of the Ministry of Health of the People's Republic of China published the "Code for the Clinical Use of Commonly Used Ototoxic Drugs", which clearly stipulates a variety of ototoxic drugs, which should be prohibited for children under 6 years old, the elderly over 60 years old and pregnant women, because pregnant women can easily enter the body of ototoxic drugs after taking drugs, destroy fetal auditory receptors, and cause congenital deafness. In addition to quinine and antibiotics, drugs or chemicals that can cause deafness include:

Salicylates such as aspirin, sulfonamides such as sulfadiazine, as well as morphine, alcohol, etc.

Common ototoxic drugs: (For reference only, not all people who take these drugs will develop ototoxicity, resulting in hearing loss.) Please be sure to follow the guidance of a professional physician or pharmacist, if you have a sensitive constitution or a family genetic history, you should inform the doctor in advance before taking the drug, and in addition, the dosage should be cautious.

1. Aminoglycoside antibiotics: streptomycin, gentamicin, kanamycin, noromycin, neomycin, tobumycin, gememycin, etc.

2. Non-aminoglycoside antibiotics: chloramphenicol, puromycin, erythromycin, vancomycin, capreomycin, chunleimycin, ridumycin, paromomycin, nitamycin, polymyxin B, etc.

3. Salicylates: aspirin, phenacetine, APC, phenylbutazone, etc.

4. Diuretics: furosemide, diuretic acid, mercury salide, etc.

5. Anti-tumor drugs: cisplatin, nitrogen mustard, bleomycin, methotine, etc.

6. Traditional Chinese medicine: aconitine, heavy metal salts (mercury, lead, arsenic, etc.).

7. Others: quinine, cloquine, propranolol, hydradazine, insulin, iodine, chlorhexidine, etc.

Drug-toxic deafness mainly refers to the damage to the auditory system caused by drugs and chemicals, some of which are cumulative damage and some are one-time damage.

There are more than 100 known drugs and chemicals, including aminoglycoside antibiotics (such as gentamicin, streptomycin, neomycin, kanamycin, vancomycin), diuretics, antipyretic analgesics, antimalarial drugs, antineoplastic drugs, and other antibiotics (chloramphenicol, erythromycin), etc.

At present, there are more than 100 kinds of ototoxic drugs that have been discovered, and the common ones are as follows:

1) Antibiotics, mainly aminoglycoside antibiotics: such as gentamicin, kanamycin, neomycin, and streptomycin, etc., in addition to aminoglycoside antibiotics, there are other antibiotics that also have ototoxicity, such as: amikamycin, noromycin, chloramphenicol, tetracycline, polymycin, vancomycin, etc. can cause ototoxicity.

2) Diuretics, such as furosemide, diuretic acid, butylureamine, etc.

3) Antineoplastic drugs: such as cischloroplatin, vincristine and nitrogen mustard.

4) Antipyretic analgesics, most commonly aspirin.

5) Antimalarial drugs, such as quinine, cloquine, etc.

In addition, there are sedative and hypnotic drugs, such as phenobarbital, heavy metal preparations such as arsenic, lead and mercury, and contraceptives such as naproxen, which can also cause deafness.

Hello, there are several categories of common ototoxic drugs:

1. Aminoglycoside antibiotics: streptomycin, gentamicin, kanamycin, neomycin, tobucin, etc.

2. Macrolide antibiotics: erythromycin, etc.

3. Other antibiotics: vancomycin, etc.

4. Salicylate: aspirin, phenylbutazone, etc.

5. Diuretics: furosemide, diuretic acid, etc.

6. Anti-tumor drugs: cisplatin, nitrogen mustard, bleomycin, methotine, etc.

7. Antimalarials: quinine, cloquine. Wait.

Bodhi is not a tree, a mirror is not a platform, there is nothing to stir up dust.

Hello, which drugs are ototoxic?

Drugs are all known, and we all know that "if it is a drug, it has three points of poison", this sentence, some drugs are also ototoxic, so what are the common drugs with ototoxicity?

Aminoglycoside antibodies.

For example, Gentarium, canaresu, neomycin, streptomycin, etc., according to relevant statistics, the deafness caused by aminoglycoside antibiotics accounts for about 1 3 of the deafness patients in recent years. These drugs are not only ototoxic when applied systemically, but also toxic to the inner ear when used topically.

Diuretics such as furosemide, diuretic acid, butylammonia, etc., the hearing loss caused by these drugs is mostly bilateral, often accompanied by tinnitus.

Antineoplastic drugs. There are cischloramine platinum, vincristine, nitrogen mustard, etc., which can damage the hair cells of the inner ear, and the deafness caused by it is irreversible.

Antipyretic analgesics.

The most common is aspirin, which can cause bilaterally symmetrical hearing loss of 40 decibels, which is mostly reversible, but can also leave severe tinnitus and permanent hearing damage.

In addition, sedative-hypnotic drugs such as phenobarbital, heavy metal preparations such as arsenic, lead, mercury, etc., and contraceptives such as naproxen can also cause deafness.

The above is the introduction of common ototoxic drugs, I hope this answer will be helpful to you, you must not ignore the attention to common ototoxic drugs, I wish you good health!

Hello, there are many drugs for ototoxicity, the most representative are aminoglycoside antibiotics , gentamicin, streptomycin, neomycin, vancomycin, etc. In addition, some diuretic and antipyretic analgesics, antimalarials, antineoplastic drugs, and other types of antibiotics can cause hearing loss. I hope my answer is helpful to you.

Hello: Which drugs are ototoxic?

Aminoglycoside antibiotics: gentamicin, streptomycin, neomycin, kanamycin, vancomycin, etc. Diuretics, antipyretic analgesics, antimalarials, antineoplastic drugs, other antibiotics (chloramphenicol, erythromycin), I hope my answer will help you!