Licorice extract related, licorice extract efficacy uses

Licochalcone a

English name: licochalcone a

cas：58749-22-7

Chemical formula: C21H22O4

Molecular weight: Physical Properties: Yellow needle crystal.

Catechism: antioxidant and anticarcinogenic effects.

Sun Mingqian. Study on the chemical composition of licorice[D]Jilin University, 2006

Chinese name of product: Isolicoside.

English name: neoisoliquiritin

Synonyms: neoisoliquiritin

cas： 7014-39-3

Pharmacological effects: anti-tumor effect, antiviral effect, anti-inflammatory and anti-immune effect, anti-ulcer effect, cough and asthma effect, hepatoprotective effect, etc.

References: Feng Jianzhong, Lu Xingzhou, Lv Jianmin, et al. The use of licorice resources to develop animal husbandry production is the first [J] resources and environment in the early dry area. 1995,9(2):84-89。

Xing Guoxiu, Li Nan, Wang Tong, et al. Research progress on the chemical components of flavonoids in licorice[J].Chinese Journal of Traditional Chinese Materia Medica,2003,28(7):593-597

Scientific name: Glycyrriza uralensis L

Aliases: beautiful grass, dense grass, dense grass, national old, powder grass, sweet grass, sweet root, stick grass.

Catalog:Tonic medicine.

English name: Licorice Roots Northwest Origin

Latin name: radix glycyrrhizae botanical name: licorice.

Properties: yellow to brownish-yellow powder.

The licorice flakes in the Chinese herbal decoction pieces are slices cut from the root of the plant licorice. Bottled compound licorice tablets are small tablets made from licorice extract and other ingredients, which belong to the category of Chinese patent medicine and all belong to the scope of traditional Chinese medicine.

Compound licorice tablets are small brown or tan tablets, and their ingredients mainly include licorice extract powder, opium powder, camphor, and star anise oil, and the main function is expectorant and antitussive. It is a compound preparation, and the main ingredient is licorice extract powder, so it is called compound licorice tablets.

It is also possible to distinguish between traditional Chinese medicine and Western medicine through the standard character of Chinese medicine. The first letter of the Chinese medicine quasi-word is z, and the first letter of the quasi-word of the Chinese medicine is not the letter z, it does not belong to the traditional Chinese medicine category.

Yes, licorice tablets usually consist of the following ingredients: licorice flow extract, star anise oil, camphor, menthol, etc. In the early days, there was a licorice flake with opium, which was addictive, and it is estimated that production has now been discontinued.

There is also a healthy version of licorice tablets. There are only two ingredients, licorice extract and star anise oil, which are said to improve immunity.

The main ingredient of licorice tablets is extracted from licorice, but a lot of other things are added. And the formula of each manufacturer is also different.

Licorice extract is a medicinal ingredient extracted from licorice. Licorice extract generally contains: glycyrrhizin, glycyrrhizic acid, glycyrrhizin, licorice flavonoids, posterior tandanin, stinging stalk, quercetin, etc.

Yellow to brownish yellow powder. It has the effect of tonifying the spleen and invigorating qi, clearing heat and detoxifying, expelling phlegm and relieving cough, relieving pain and relieving pain, and harmonizing various medicines. It is used for spleen and stomach weakness, fatigue and fatigue, palpitations, shortness of breath, cough and phlegm, abdominal and limb cramps, and other diseases.

Licorice extract can be used both edibly and topically.

Plants must contain plant hormones, which are not harmful to the human body.

Active ingredient of licorice:

Ingredients of licorice] mainly contain glycyrrhizin, which is calcium salt and potassium salt of glycyrrhizic acid. After glycyrrhizic acid is hydrolyzed, glucuronic acid, glycyrrhetinic acid. It also contains flavonoids glycyrrhizin, glycyrrhizin, isoglycyrrhizin, isoglycyrrhizin and glycyrrhizinone, mango stalk xanthocin, glycyrrhizin, isoligitridin, resin, etc.

Pharmacology of licorice].

1.It has antispasmodic effect and anti-ulcer activity.

2.It has antitussive expectorant, sedative, anti-inflammatory, antibacterial, antiallergic, and non-specific immune enhancement and mineralocorticoid-like deoxycorticosterone.

3.It has a detoxifying effect on a variety of drugs and poisons.

4.It has the effect of retaining water and sodium, increasing blood pressure and increasing potassium excretion.

Precautions] 1It should not be used with gansui, euphorbia, coriander, and seaweed.

2.The spleen and stomach are damp and sleepy, and those who are full of vomiting are forbidden to take it.

3.Long-term use in large quantities can cause edema, high blood pressure, etc.

Licorice is a tonic in traditional Chinese medicine. Sweet in taste and flat in nature. Return to the stomach, heart, and lung meridians.

Glycyrrhizic acid. Potassium is the active ingredient for licorice sweetening, which is a pure natural extract extracted from licorice.

The main ingredient is glycyrrhizic acid. It has high sweetness, strong licorice special fragrance, low calorie safety, non-toxicity and strong health care function, which is hypertension.

Obesity, diabetes.

The most ideal sweetener for heart disease patients can compensate for the disadvantages of sweeteners such as sucrosein inducing the above diseases.

Method: Licorice extract is obtained by extracting and refining natural licorice as raw material.

Properties: yellow to off-white crystalline powder, odorless and special sweetness. It is easily water-soluble and soluble in ethanol.

Characteristics: It has high sweetness, low heat energy, safe and non-toxic and strong health care efficacy, is the most ideal sweetener used by patients with hypertension, obesity, diabetes and heart disease, has a strong special fragrance of licorice, has the effects of health care, detoxification, liver protection, anti-inflammatory, flavoring, etc., and is an ideal pure natural sweetener raw material.

Uses: Suitable for canned meat, seasonings, condiments, soy sauce, soybean paste, salad dressings, pickled products, frozen sweets, chewing gum, betel nut, bread food, candy preserves.

Biscuits, low-sugar foods, sugar-free foods, fruit juices, dairy products, milk powder, functional drinks.

Wait. Use: Dissolve in water at room temperature and add to food according to the needs of the process.

Dosage: The general dosage is 3 -5, which can be appropriately adjusted according to the flavor requirements of its own products.

Storage: Store in a closed and dry place, and it is forbidden to mix with toxic substances.

Monopotassium glycyrrhizic acid salt is yellow to white fine powder, rich licorice special fragrance, sweetness is 100-200 times that of sucrose, soluble in water, clear and transparent solution, good taste, sweetening and flavoring, flavoring and efficiency, anti-spoilage mildew, anti-precipitation, high sweetness, low heat energy, is the most ideal sweetener for patients with hypertension, obesity, diabetes and heart disease.

[Identification].

1) Cross-section of this product: The cork layer is a series of brown cells. The cortex is narrower.

Phloem rays are broad, often curved, and often fissures; The fibers are mostly bundled, non-lignified or microlignified, and the surrounding parenchyma cells often contain calcium oxalate square crystals; Screen clusters are often deformed by compression. Intrafascicular cambium is distinct. xylem rays 3 to 5 rows of cells wide; There are many catheters, with a diameter of about 160 m; The wood fibers are bundled, and the surrounding parenchyma cells also contain calcium oxalate quarangular crystals.

The root center is unpulidated; The rhizome has a pith in the center. The powder is pale brownish-yellow. The fibers are bundled, with a diameter of 8 14 m, thick walls, microlignified, and the surrounding parenchyma cells contain calcium oxalate cubic crystals to form crystal fibers.

Calcium oxalate cubic crystals are more common. Bordered perforated ducts are larger, and reticulated ducts are rare. Cork cells are reddish-brown, polygonal, and microlignified.

2) take 1g of powder of this product, add 40ml of ether, heat and reflux for 1 hour, filter, add 30ml of methanol to the residue, heat and reflux for 1 hour, filter, evaporate the filtrate, add 40ml of water to the residue to dissolve, extract 3 times with n-butanol, 20ml each time, combine n-butanol solution, wash with water 3 times, evaporate dry, add 5ml of methanol to the residue to dissolve, as a test solution. In addition, 1g of licorice control herbs was taken to make a control herb solution by the same method. Ammonium glycyrrhizinate reference substance was then added, and methanol was added to make a solution containing 2mg per 1ml as a control solution.

According to the thin layer chromatography (Appendix B) test, 1 2 L of each of the above three solutions were absorbed, and they were respectively placed on the same silica gel G thin layer plate prepared with 1% sodium hydroxide solution, and the acetate ethyl acetate, formic acid, glacial acetic acid, and water (15:1:1:

2) As an agent, take it out, dry it, spray it with 10% sulfuric acid ethanol solution, heat it at 105 degrees Celsius until the spots are clearly colored, and place it under ultraviolet light (365nm) for inspection. In the chromatography of the test product, fluorescent spots of the same color are displayed at the corresponding position of the chromatography of the control medicinal material; At the position corresponding to the control chromatogram, the same orange-yellow fluorescent spot is displayed.

[Content determination].

Determined by high-performance liquid chromatography (Appendix D).

Chromatographic conditions and system suitability test Eighteen alkyl silane bonded silica gel was used as filler; Methanol ammonium acetate solution-glacial acetic acid (67:33:1) is the mobile phase; The detection wavelength is 250nm. The number of theoretical plates should not be less than 2000 calculated according to the monoammonium glycyrrhizinate salt peak.

Preparation of reference solution Take about 10mg of monoammonium glycyrrhizinate salt reference substance, weigh it accurately, put it in a 50ml measuring flask, dissolve it with mobile phase and dilute it to the scale, shake it well, and obtain (per 1ml of the reference substance containing monoammonium glycyrrhizinate, which is converted to glycyrrhizic acid.

Preparation of test solution take about the powder in this product, weigh it accurately, put it in a 50ml measuring flask, add about 45ml of mobile phase, sonicate (power 250W, frequency 20kHz) for 30 minutes, take it out, let it cool, add mobile phase to the scale, shake well, filter, and obtain.

Determination method Accurately absorb 10 l of the reference solution and the test solution respectively, inject it into the liquid chromatograph, and measure.

This product contains glycyrrhizic acid (C42H62O16) shall not be less than.