What are the functions of the fermenter? What are the process requirements for fermenters

Fermentation tank refers to the device used in industry for microbial fermentation. Its main body is generally a main cylinder made of stainless steel plates, and its volume is from 1m3 to hundreds of m3. In the design and processing, attention should be paid to the structure is tight and reasonable.

It can withstand steam sterilization, has a certain degree of operational flexibility, minimizes internal accessories (to avoid dead ends), has strong material and energy transfer performance, and can be adjusted to facilitate cleaning and reduce pollution, which is suitable for the production of a variety of products and reduces energy consumption.

Shanghai Aiyan Biotechnology Co., Ltd. is a professional manufacturer of imported laboratory reagents, chemical products, laboratory consumables and laboratory equipment. The unique design of the company's infors fermentation tank makes the minifors extremely flexible, easy to use, and easy to operate, which reduces the user's workload and saves the user a lot of time wasted on fermenter maintenance. Heated by infors' unique metal module jacket with an embedded cooling water loop for temperature control, temperature control range:

Higher than room temperature culture, no need for water bath cooling, reduce the water environment around the tank, greatly reduce the probability of infection in the culture process, lower than room temperature culture, can be directly connected to the chiller through the embedded cooling water circulation circuit for cooling, working temperature range: cooling medium temperature +5 60. The ultra-compact body design not only saves laboratory space, but also reduces the total length of the pipeline by 30%-50%, greatly reducing the probability of infection.

The classification of fermentation tanks mainly used in China is divided into mechanical stirring and ventilation and non-mechanical stirring ventilation fermenters according to the equipment of fermentation tanks; According to the growth and metabolism needs of microorganisms, it is divided into aerobic fermentation tank and anaerobic fermentation irrigation.

Fermenters for anaerobic fermentation (e.g. production of alcohol, solvents) can be simpler. The requirements for this type of fermenter are: it can be closed; Able to withstand a certain amount of pressure; There is cooling equipment; The device in the tank is minimized, and the dead angle is eliminated, which is convenient for cleaning and sterilization.

Alcohol and beer are both gas-like fermentation products, and their fermentation tanks are much simpler than gas-free fermentation equipment because they do not need to be fed expensive sterile air.

The fermentation tank used for good gas fermentation (such as the production of antibiotics, organic acids, vitamins, etc.) needs to continuously introduce a large amount of sterile air into the tank, and in order to consider the utilization rate of the imported air, the structure of the fermentation tank is more complex, and the commonly used fermenters are mechanical stirring, bubbling and airlift fermenters.

The fermenter equipment adopts the internal circulation method, which uses the stirring paddle to disperse and break the bubbles, which has a high dissolved oxygen rate and a good mixing effect. The tank body is made of SUS304 or 316L imported stainless steel, and the tank is equipped with an automatic spray cleaning head to ensure that the production process meets the GMP requirements. Fermenters are widely used in dairy, beverage, bioengineering, pharmaceutical, fine chemical and other industries.

In recent years, with the continuous progress of science and technology, the fermentation industry, which is related to the national economy and people's livelihood, has achieved rapid development, and the fermentation equipment has also been updated from traditional to modern.

The main body of the tangerine fermentation tank is equipped with a sandwich, an insulation layer, which can be heated, cooled and kept warm. The tank body and the upper and lower elliptical heads (or prototypes) are all processed by spinning R angle, and the inner wall of the tank is mirror-polished, which is hygienic and has no dead ends, and the fully enclosed design ensures that the material is always mixed and fermented in a pollution-free state (at the inlet and outlet). The equipment is equipped with air breathing holes, CIP cleaning nozzles, manholes, inlet and outlet and other devices.

Fermentation tanks are widely used in dairy product fermentation, beer fermentation, wine fermentation, kitchen waste treatment equipment, food wastewater processing, winery wastewater treatment equipment, biogas fermentation equipment and other fields.

The fermenter is the core equipment that provides a good reaction environment for microbial fermentation, cell culture, and enzyme reaction to complete the biocatalytic reaction, often called a bioreactor or multi-enzyme reactor, and undertakes the production of products.

The structure, operation and operation of the fermenter are closely related to the quality, conversion rate and energy consumption of bioprocess products. An excellent incubation device should have a tight structure, good liquid mixing performance, high heat transfer rate, and should also have a supporting and reliable detection and control system.

The only criterion for testing the fermentation equipment should be whether the equipment can be adapted to the process requirements in order to obtain production benefits.

1. Shanghai Bailun Biotechnology****Main products: bioreactors (fermenters), fully equipped with automatic fermenters, control systems and technical services.

2. Jining Dadi Engineering Installation Co., LtdMain Products: Oil Tanks, Oil Tank Equipment, Steel Storage Tanks, Asphalt Insulation Oil Tanks, Large Vertical Tanks, New Oil Truck Tanks, Mixing Tanks, Fermentation Tanks.

3. Changzhou Sangao Biotechnology Engineering ****

4. Changchun Hengwei Industrial Co., LtdMain Products:Fermenter.

5. Amur Forestry BureauMain Products: Liquid bacteria fermentation tank. Dig your fingers.

How it works.

Inner circulation with lift fermenter, outer circulation with lift fermenter.

The height of the circulating tube is the main factor affecting the circulating efficiency, and it has been proved in practice that it should not be less than 4m.

Compared to universal fermenters, it has the following advantages:

a) There is no stirring device in the fermenter, which is easy to clean and easy to process.

b) Power consumption is significantly reduced due to the elimination of the motor for stirring and the ventilation volume is approximately equal to that of the universal fermenter.

Wood fermenter.

The agitator is welded to a disc with six curved air pipes that doubles as an air distributor. The air is introduced by the hollow shaft, blown out through the hollow tube of the agitator, mixed with the liquid thrown out by the agitator, and the fermentation broth rises on the outside of the sleeve and descends from the inside of the sleeve to form a circulation.

Venturi fermentation equipment.

The principle is to use a pump to hydraulically inject the fermentation into the venturi tube, and due to the increase in the flow rate of the liquid in the shrinkage section of the venturi tube, a negative pressure is formed to draw the air in, and the bubbles are dispersed and mixed with the liquid, increasing the dissolved oxygen in the fermentation broth. The advantages of this kind of equipment are: high efficiency of oxygen absorption, uniform mixing of gas, liquid and solid phases, simple equipment, no need for air compressor and agitator, and power consumption is saved.

This device is used in the sealed cabin of a spacecraft, using the photosynthesis of algae to reduce carbon dioxide from the gas to oxygen.

The fermentation is hydraulically pumped into the venturi, and as the flow rate of the liquid in the shrinkage section of the venturi increases, a vacuum is formed to draw the air in, and the bubbles are dispersed and mixed with the liquid, so that the microorganisms can obtain the oxygen needed for growth and metabolism.

It provides a good growth space for microorganisms, in which the sterility of nutrients, sufficient oxygen, uniform mixing, reasonable temperature and pressure can be guaranteed. Let the microbes grow healthily in this space.

1.The fermenter has no dead angle and can be completely sterilized.

2.The fermenter is airtight. It will not be polluted by the outside world.

3.A sterile ventilation system provides microorganisms, or oxygen for cell growth. or anaerobic fermentation of nitrogen, carbon dioxide for physiological regulation.

4.By mechanical stirring, or air flow mixing, the material can be fully mixed in the tank to ensure mass transfer.

5.The fermenter has a complete set of control system, which involves feeding control, temperature control, pH control, stirring speed control, liquid level control and so on. Different fermenters have different degrees of automation. As for the PID control principle, please learn it yourself.

The differences between enzymatic hydrolysis tank and fermenter are as follows:

1.Function: The function of the enzymatic hydrolysis tank is that it can be heated, cooled, kept warm, stirred, and inactivated by enzymes, while the function of the fermentation tank is used for different kinds of fermentation, such as the production of alcohol, solvent and other anaerobic fermentation, as well as the production of antibiotics, amino acids, organic paralylanic acid, vitamins and other good gas fermentation.

2.The structure of the fermentation tank used for anaerobic fermentation is relatively simple, while the fermentation tank used for good gas fermentation is more complex in structure because it needs to continuously introduce a large amount of sterile air into the tank and consider the utilization rate of air, such as mechanical stirring fermenter, bubbling fermentation tank and airlift fermenter.

In general, although enzymatic hydrolysis tanks and fermenters are biological reaction equipment, their functions and structures have their own characteristics, and they are selected and used according to actual needs.

The difference between an enzymatic hydrolysis tank and a fermentation tank is that the functions are not the same. Enzymatic hydrolysis tank function: it has the functions of heating, cooling, heat preservation, stirring, and enzyme inactivation (the enzymatic hydrolysis temperature can be equipped with an automatic temperature control device).

FermentersThe structure of the fermenter used for anaerobic fermentation (e.g. production of alcohol, solvents) can be relatively simple. The fermentation tank used for good gas fermentation (such as the production of antibiotics, amino acids, organic acids, vitamins, etc.) needs to continuously introduce a large amount of sterile air into the tank, and in order to consider the utilization rate of the imported air, the structure of the fermentation tank is more complex, and the commonly used ones are mechanical stirring fermentation tank, bubbling fermentation tank and airlift fermenter.

The universal fermenter is equipped with both a mechanical agitator and a compressed air dispersion. Its height-to-diameter ratio is 2:1-6:

19。Therefore, the working principle of the general-purpose fermentation tank, which can be widely used in the deep gas cultivation equipment, is: the axial and radial flow of the materials is generated by mechanical stirring and stirring, so that the materials in the tank are well mixed, and the solids in the liquid are kept in a suspended state, which is conducive to the full contact between solids and nutrients and is convenient for nutrient absorption; On the other hand, it can break the bubbles, increase the contact area between gas and liquid, increase the mass transfer rate between gas and liquid, enhance the oxygen transfer effect and eliminate foam.

At the same time, sterile air is introduced to maintain the oxygen needs of the bacteria to meet the growth and fermentation of aerobic bacteria.

1.B. Braun fermenters: advantages:

The market share of imported fermenters in China is more than 70%, with good after-sales service and perfect application technical services. Special advantages: B. Braun fermentation tanks are equipped with a cabinet-type integrated automatic association control system.

The advantage of correlation control is that it can automatically adjust the parameters of the overall fermentation requirements at multiple levels. During the fermentation process, through the setting and adjustment of the PID control accuracy and range, the motor speed, dissolved oxygen, pH, temperature, and intake and exhaust gas can be effectively protected from huge errors in automatic correlation control. This feature is very important for the optimization and effective control of the fermentation process, which is not available in other brands.

2. The fermentation tank of NBS company in the United States: the comprehensive performance is comparable to that of the Swiss biot fermenter, but the accuracy of dissolved oxygen control is slightly higher than that of the latter (0-100 vs 5 -95) and the range is wider; The tank was slightly larger (5L vs; pH control accuracy is high (vs

3. Swiss Biou fermenter: the comprehensive performance is equivalent to that of the NBS fermentation tank in the United States. Special advantage: low price.

Lehui, Nanji two-day brand.

Summary. Fermenters and extraction tanks are two different pieces of equipment that are mainly used in different processes. The fermentation tank generally refers to the equipment used in the microbial fermentation manufacturing process, which is used to contain fermented substances, microorganisms and nutrients, etc., and promotes the metabolic activities of microorganisms by controlling temperature, oxygen**, pH value and other conditions, so that fermentation substances can be processed and transformed.

Fermenters are usually constructed with an airtight or semi-closed structure to prevent the ingress of bacteria and dust in the air. Extraction tanks generally refer to equipment used in chemical or pharmaceutical manufacturing processes to extract useful substances from solids, liquids, or gases. The principle of operation of the extraction tank is to use the selectivity of the solvent to extract the substances that need to be extracted from the mixture, and then separate and purify the substances through methods such as separation and filtration.

Therefore, although fermenters and extraction tanks are both equipment used to process processed substances, they differ in terms of application scenarios, process principles and methods of use.

Can you add, I don't quite understand it.

Fermenters and extraction tanks are two different pieces of equipment that are mainly used in different processes. The fermentation tank generally refers to the equipment used in the microbial fermentation manufacturing process, which is used to accommodate fermented substances, microorganisms and nutrients, etc., and promotes microorganisms to carry out the activities of substitution by controlling temperature, oxygen**, pH value, etc., so that the fermented substances can be processed and transformed. Fermenters are usually constructed with an airtight or semi-closed structure to prevent the ingress of bacteria and dust in the air.

Extraction tanks generally refer to equipment used in chemical or pharmaceutical manufacturing processes to extract useful substances from solids, liquids, or gases. The principle of operation of the extraction tank is to use the selectivity of the solvent to extract the substances that need to be extracted from the mixture, and then separate and purify the substances through methods such as separation and filtration. Therefore, although the fermentation tank and the extraction tank are both equipment used to process and process substances, their application scenarios, process principles and usage methods are different.

The differences are as follows.

1. Fermentation tank refers to the device used for microbial fermentation in the slow erection industry. Fermentation tankFermentation tank is a kind of tank used to ferment dairy products and wine, and it is also a closed vessel or biological reaction device that is larger than the cultivation of microorganisms or cells.

Seasoning tank, also known as mixing tank, mixing tank, has the advantages of energy saving, corrosion resistance, strong production capacity, easy cleaning, simple structure, etc., mainly used for dairy and sugar and other elements and various drugs to stir and homogeneous.