What causes essential tremor?

The cause of the disease is unknown, but it may be genetic.

The exact condition of essential tremor is still unknown, but modern studies have found that genetics and environmental factors can cause essential tremor.

Essential**. Essential tremor is caused by abnormal signaling in specific areas of the brain, including the cerebellum, thalamus, and brainstem. The exact cause of the disease is unknown, but about 30% to 50% of patients have a family history and are inherited in an autosomal dominant manner.

However, some people who have no family history can also get the disease.

Predisposing factors. Studies have found that the level of dehydrocamel spine in patients with familial essential tremor is higher than that of the normal population, and dehydroscarpine is a neurotoxic substance that can cause tremor, which is found to be high in meat after prolonged high-temperature cooking.

Heavy metals such as lead and smoking in the diet may also be associated with the onset of essential tremor.

Causes of essential tremor: 1. Genetic predisposition: Although the occurrence of essential tremor is related to aging and environmental toxins, not all elderly people or people exposed to the same environment, even people who also smoke a large amount of MPTP will develop essential tremor.

Although there is also a familial agglomeration phenomenon in patients with essential tremor, no clear pathogenic gene has been found in sporadic patients with essential tremor so far, indicating that the ** of essential tremor is multifactorial. 2. Aging: The disease mainly threatens the health of the elderly, and China is constantly entering an aging society, which is also the main factor for the rising incidence.

3. Familial hereditary: In long-term practice, medical scientists have found that essential tremor seems to have a tendency to gather in families, and the incidence of essential tremor patients in their relatives is higher than that of the normal population.

Suggestions: Fourth, environmental factors: epidemiological investigation results found that the occurrence of the disease is mainly due to toxic substances infringing on the neurons of the brain, with the development of society, environmental pollution has become more and more serious.

**Unknown, some patients may have a genetic mutation that causes the onset and a family history of tremor[3][4].

Patients with a family history of essential tremor present at an earlier age, usually before the age of 20 years [

Essential tremor is generally caused by genetic factors, such as heavy smoking and drinking, changes in environmental temperature, excessive emotions, excessive fatigue, frequent late nights, drug poisoning, and high heavy metal content in the diet. If the patient's symptoms are mild, they can be observed first and no special treatment should be taken. If the condition is slightly severe, drugs such as adrena-blockers** can be used under the guidance of a doctor, or acupuncture and traditional Chinese medicine can be used to alleviate the symptoms.

In daily life, men also need to develop healthy lifestyle habits and maintain a good attitude. Essential tremor is followed by symptoms typical of migraine, and malignant hyperthermia has also been reported. The only symptom of tremor is tremor, which generally consists of both upper limbs, head, legs, trunk, voice, facial muscles, and rarely involves the lower limbs.

The diagnosis of essential tremor includes diagnostic criteria and exclusion criteria. Tremor is based on symptoms, signs, onset, and exclusion of other disorders, medications, trauma, or psychogenic tremors.

Chen Biao's expert group of medical classics.

Chief physician of Xuanwu Hospital, Capital Medical University.

Director of the National Clinical Research Center for Geriatric Diseases, Director of the Parkinson's Disease Research Institute of the Beijing Institute of Major Brain Diseases.

Uncontrollable tremors in the hands, head, and even voice.

The disease manifests only as tremor and does not affect life expectancy.

Onset increases with age, often with a family history.

Drugs are preferred**, and surgery may be considered in severe cases.

Disease definition. Essential tremor, also known as essential tremor and familial tremor, is an autosomal dominant genetic disease, which is mainly manifested as involuntary tremor of the upper and lower limbs or head and face, and sometimes vocal tremor.

The conventional wisdom is that essential tremor is a benign movement disorder that manifests only as tremor and does not affect life expectancy. However, there is now growing evidence that essential tremor or senile tremor is associated with aging, with people aged 65 years with essential tremor 4-fold more likely to progress to Parkinson's disease.

Epidemiology. The incidence of essential tremor is about % with age, with an incidence of about 40 years of age and about 65 years of age.

Essential tremor tends to run in families, with 30 to 50 patients having a family member with essential tremor. Patients with a family history of the disease develop the disease at an earlier age, most before the age of 20, and patients without a family history usually develop the disease after the age of 40. Labor loss due to tremor usually occurs 10 to 20 years after the onset of the disease.

Type of disease. Depending on whether the patient has a family history, it can be divided into familial tremor and sporadic cases. The clinical features of the two groups of patients are almost identical.

Resources. 1] Parkinson's Disease and Movement Disorders Group, Chinese Society of Neurology. Diagnosis and guidelines for essential tremor [J].Chin J Neurol,2009,42(8):571-572

2]lottis ed. essential lyemor. lancet neurol, 2005. 4: 100-110.

Pathological atrial fibrillation is often an organic heart disease such as rheumatic heart disease, mitral stenosis, dilated myocarditis, hypertensive heart disease and coronary heart disease (especially left ventricular diastolic function restriction caused by left atrial enlargement), valvular calcific heart disease, etc., which can cause the left atrium to enlarge to a certain extent, and countless micro-reentry channels are formed in the atrium (in layman's terms: many short circuits that can be repeated are formed in the enlarged atrium, and this short circuit is opened with a reentry frequency of 350-600 minutes to send out electrical excitation, And through the atrioventricular node between the atria and the ventricle conduction to the ventricle, of course, the atrioventricular node after the electrical stimulation needs to rest after the repolarization of the electrocardiogram can be transmitted down to the atrial micro-reentry conduction of electrical excitation, so the ventricular rate of atrial fibrillation is about 90-150 minutes).

Idiopathic atrial fibrillation refers to atrial fibrillation that does not result in left atrial enlargement due to the absence of a cardiac background, i.e., not due to micro-reentry due to atrial enlargement. It tends to occur suddenly, stops abruptly, and can last as little as a few seconds, but can last for several hours or longer, but eventually returns to normal sinus rhythm, sometimes with brief atrial flutter during the transition. For a long time, because the cause cannot be found, it is called idiopathic or sudden atrial fibrillation.

With the progress of cardiac electrophysiology diagnosis and treatment, the cause of idiopathic atrial fibrillation has finally been found, that is, some people are born with some micro-reentrant channels below the pulmonary vein before the start of the left atrium, and there are also congenital micro-reentrant channels around the left atrial appendage and around the mitral valve orifice. Isn't that atrial fibrillation after birth? In fact, this is not the case, and these micro-reentry channels are usually not open, unlike the micro-reentry channels that are always open due to the extreme enlargement of the left atrium.

It is only when certain electrophysiological activities of the heart can be caused that the congenital micro-reentrant channel is activated and opened, resulting in an idiopathic atrial fibrillation.

So what exactly activates the innate micro-reentrant channels in the atrium? Modern medicine is not clear, we are not going to stop idiopathic atrial fibrillation from how to prevent micro-reentrant activation, but to take another destructive **: radiofrequency ablation of possible congenital micro-reentrant sites through direct current, in addition to excessive dyeing, we all know the problem of success rate and **rate, which may be the current ** measure with a certain effect, but in the future medicine will definitely tell you that this is not the best choice.

The focus of modern medicine has gradually shifted from ** to prevention, which is the true meaning of medicine and the duty of doctors.

So what is the better way to prevent sudden atrial fibrillation attacks than destructive, which is caused by the limitations of the modern biomedical model! Has the various causes of idiopathic atrial fibrillation occur, both physical and psychological, and what neurological or humoral factors can activate the microreentrant pathway? Has anyone studied it?

If these problems can be solved, this is a new level of modern medicine, medical science will never have an end, only a starting point, if you do not break through the original way of thinking of the predecessors, no matter how much research can only be a turtle, there is no future without a breakthrough!

The causes of essential tremor are: 1. Increasing age: Essential tremor is a disease of brain decline, which mostly occurs in the elderly over 50 years old.

Second, environmental factors, at present, it is believed that the main harm to the human body is caused by herbicides, pesticides, carbon monoxide, mercury, manganese poisoning and other chemical substances. 3. Familial hereditary. 4. Drug factors:

Taking large doses of sedatives and antipsychotics.

Heredity and lifestyle habits are all related.

There are many causes of essential tremor, but they are not well understood, and may be related to genetic factors, environmental factors, allergies such as eating seafood, cold or fatigue. It is recommended that patients should go to the hospital for examination in time after the occurrence of essential tremor to find out the **symptomatic**, and the patient should also develop good living and eating habits and pay attention to rest.

The causes of essential tremor include the following: 1. Aging. 2. Familial hereditary: Essential tremor seems to have a tendency to gather in families, and the incidence of relatives of patients with essential tremor is higher than that of normal people.

Essential tremor is an autosomal dominant disorder and is the most common extrapyramidal disorder characterized by tremor or rhythmic involuntary movements of the head, face, jaw, tongue, and lower extremities. It is chronic, with a slow and progressive progression.

Visiting the department. Neurology.

Alias. Familial tremor, benign essential tremor.

Clinical symptoms. Postural tremor and action tremor are the only clinical manifestations of the disease and are often found in one or both upper limbs, often with the head and less often in the lower extremities. In some patients, tremor can be temporarily reduced after drinking alcohol, and tremor can be aggravated by emotional agitation or nervousness, fatigue, and cold.

Harm. Not only can it cause physical and social embarrassment, but it can also interfere with fine motor activities such as writing, and when the laryngeal muscles are affected, it can affect speech.

Complication. Affects pronunciation, etc.

Examine. CT, MRI, electromyography, thyroid function, genetic analysis, etc.

Diagnosis. Diagnosis is based on family history and typical symptoms.

**Principle. Give -receptor blockers** and, if necessary, surgery**.

**Sex. Early**, effective symptom control.

Dietary advice. Supplement your diet with enough calories.

Essential tremor**:

1. Familial heritability is the main predisposing factor of essential tremor. In long-term practice, medical scientists have found that essential tremor seems to have a tendency to cluster in families, and the incidence of essential tremor in the family and relatives of patients with essential tremor is higher than that of the normal population.

2. Aging is also the predisposing factor of essential tremor, essential tremor mainly occurs in middle-aged and elderly people, and the onset before the age of 40 is rare, indicating that aging is related to the onset of the disease, studies have found that since the age of 30, the activity of dopaminergic neurons in the substantia nigra, tyrosine oxidase and dopa decarboxylase, and the level of dopamine transmitters in the striatal body gradually decrease with age, however, only a small number of elderly people suffer from this disease, indicating that physiological dopaminergic neuronal metamorphosis is not enough to cause disease, and aging is only the precipitating factor of the disease.

3. Environmental factors are also predisposing factors for essential tremor. Epidemiological findings have found regional differences in the prevalence of essential tremor, leading to suspicion that there may be some toxic substances in the environment that damage neurons in the brain.

Current studies have found that essential tremor is mainly genetically related and is the dominant inheritance of chromosomes, because most patients are familial clusters, and there is no research on its specific ** and pathogenesis.

The only symptom that patients with essential tremor experience is tremor, which can be in the upper limbs, the head, or other parts of the body, and the more intense, nervous, anxious, and fatigued, the more likely it is to appear. Most patients develop the disease at a young or middle-aged age, and the disease progresses gradually, and may affect the patient's life and work decades later.

But in the early days, when it didn't affect life and work, there was no need for special **. A small amount of alcohol can reduce the onset of tremor, but this is only temporary, and for more obvious symptoms, propranolol can be used to **.