Why does glioblastoma recur and is it inherited?

Because glioblastoma is a malignant tumor, it can metastasize, for example, into the blood, lymphatic vessels, or other tissues, and may recur due to the remnant of undetectable cancer cells.

Cancer is related to heredity, but cancer is not directly inherited, different tumors may have different ways of genetic transmission, and the role of genetic factors in most tumorigenesis is the susceptibility or predisposition to carcinogenic factors, the so-called genetic susceptibility to cancer refers to the population under the same living conditions, some individuals have a tendency to be more prone to cancer, on the basis of certain genetic characteristics, whether cancer is formed, but also depends on mental factors, environmental factors, The combined effect of many acquired factors such as dietary factors and lifestyle habits and external carcinogens.

Whether gliomas are hereditary or not is medically inconclusive.

This is determined by the characteristics of the glioma itself." On the one hand, gliomas mostly grow in the brain as "root-like" infiltrative, with no clear boundary with normal brain tissue, which cannot be completely removed by surgery, and are not very sensitive to chemoradiotherapy, so it is very easy**; In addition, gliomas have the characteristics of "leek-like" regeneration and proliferation, and the malignancy of the tumor increases with the prolongation of the course of the disease.

With the in-depth research and research in the field of glioma diagnosis and treatment, there are also some new and effective **. The most significant and safest solution to the problem from the root is to take surgery as the guide, combined with the biological ** targeted glioma stem cells and the personalized ** characteristics of molecular detection guidance, that is, the bioknife technology of glioma. It can effectively kill glioma stem cells and delay avoidance.

People usually ignore the value of the glioma tissue that has been removed after surgery, and it is wrong to discard it; These tissues can be placed in the glioma stem cell bank of the Center for Translational Neuroscience for tissue culture and feature extraction, so that if once our patients can timely target the pathological characteristics of individual glioma, this is the safest way.

What are the causes of glioma**? Glioma** has always been a major problem for people, and medical professionals in the medical community have been working hard to find ways to avoid glioma**, but there has not been much progress, and this problem still exists. Although we can't avoid glioma** very well, we can understand some of the causes of glioma** so that we can prevent it in the future.

1) The cause of the disease.

The nature of the tumor is almost always glioma, with astrocytoma and glioblastoma multiforme being the most common, and some can be ganglioglioma and ependymoma. Low-grade malignant astrocytomas are the main ones located in the upper part of the brainstem, while glioblastoma is the most common in the lower part of the brainstem.

ii) Pathogenesis.

1.Fibrous type.

is a common type. There are glial fibers in the tumor, which is the main difference from the plasma type, the tumor texture is tougher, and the section surface of the diffuse fibrous type is white, which is not easy to distinguish from the white matter of the brain. The adjacent cortex is often infiltrated by the tumor, darkens in color, blurs the demarcation with the white matter, and may have cystic changes in the tumor center.

Focal fibrous forms with smooth borders, predominantly in the cerebellum, often cystic changes. There are glial fibers in the microscopic interstitium, which are cross-distributed between tumor cells, which are fibrous astrocytes.

2.The puree type is the least common type. The section is translucent and uniformly jelly-like, deeply invading the white matter, with unclear borders, often degeneration, and cysts. Microscopically, the tumor is composed of protoplasmic astrocytes.

The incidence of glioma is 3 10 100 000, accounting for 1% of all malignant tumors, and the average survival time of surgery plus chemoradiotherapy is only 8 to 11 months. Globally, malignant gliomas ruthlessly claim the lives of 18.6 million young and middle-aged people every year. Gliomas are infiltrative growths that have no clear boundary with normal brain tissue and are difficult to remove completely.

Moreover, gliomas are not very sensitive to radiotherapy and chemotherapy, and are very easy**, and benign and malignant tumors that grow in important parts of the brain are difficult to remove or cannot be operated at all. Chemical drugs and general anti-tumor drugs are not ideal due to the influence of factors such as the blood-brain barrier.

At present, the mode of surgery-radiotherapy-chemotherapy has been accepted by our general neurosurgeons, but a strange phenomenon has now been formed in terms of the effect, that is, the treatment is long, long and cured, and the cycle repeats. Therefore, most neurosurgeons adopt a conservative attitude and approach.

Due to the influence of blood-brain barrier and other factors, the efficacy of chemical drugs is not ideal, so glioma is still one of the tumors with the worst prognosis among the systemic tumors. A significant proportion of intracranial tumors are treated after surgery** because the tumor is not completely removed or regrown.

In addition, it is worth mentioning that the "DC-CIK Biological Immunity" of Beijing Neuro-Oncology Center, which cooperates with the traditional program, has been successfully carried out in our hospital in terms of brain tumors and has received good results.

Glioma bioknife technology is a method that has been studied in recent years, mainly for patients. It is still difficult to avoid surgery for patients in the early stage, and it can be said that surgery is a foundation. As many family members of patients say, it is not always possible to do so many surgeries.

The surgically removed tissue is not known to those hospitals to study, maybe there is some way.

It is important to note that the surgically removed glioma tissue is very important, please do not discard it, because it can be used to grow the sample and perform feature extraction, and then pass the extracted features to the "immune cells" in our body that have the ability to kill tumor cells. That's pretty much it.

These tissues can be placed in the glioma stem cell bank of the glioma diagnosis and treatment center of Bayi Brain Hospital, and the tissue culture and feature extraction can be carried out, so that if once our patients can timely target the pathological characteristics of individual glioma, this is the safest way.

Gliomas are often difficult to remove. If it is grade 1 glioma, there is hope, grade 2-4, the possibility of ** is very high, and you need to continue to improve your own immunity.

At present, the most effective method is to carry out glioma immunization**. The surgically resected glioma tissue is placed into the glioma stem cell bank of the Center for Translational Neuroscience to isolate, culture, and store the patient's own glioma stem cells.

It not only solves the problem of scarcity of glioma antigens, but also provides an opportunity for those patients who have lost the opportunity to undergo the glioma DC vaccine**. Figuratively speaking, the glioma stem cell bank not only stores cells, but also provides an opportunity to target glioma stem cell immunity, which is the hope of delaying.

You can, but it's not easy to be benign**.

Gliomas are generally difficult to remove. If it is grade 1 glioma, there is hope, grade 2-4, the possibility of ** is very high, and you need to continue to improve your own immunity.

If you want to avoid it, you need to completely remove the stem cells of this glioma, which is difficult for traditional surgery, but surgery is an early means. Therefore, it is most effective to perform glioma bioknife after surgery. The general principle is to put the surgically removed glioma tissue into the glioma stem cell bank of the Center for Translational Neuroscience, culture and feature extraction, and then let these good cells kill and inhibit the glioma stem cells.

For specific explanations, you can consult relevant experts and list a few Professor Dai Yiwu and Qin Jiazhen. Location of the glioma stem cell bank: It is of great significance to patients if glioma tissue can be sent to this bank in the glioma diagnosis and treatment center of Bayi Brain Hospital as soon as possible.

Feature extraction and antibody culture can be carried out for patients, so that glioma tissues can be killed and targeted with extreme precision. Hope it helps. More specifically, you need to consult a professional.

Glioblastoma has undergone craniotomy and the skull is removed, but will it break the scalp?

Glioblastoma is a type of glioma.

At present, the more effective method is to carry out the synthesis of glioma bioknife**, but the glioma tissue after surgery is very precious to the patient's life, and it should be sent to the glioma stem cell bank in a timely manner.

The glioma stem cell bank is known as the life bank of glioma patients, in layman's terms, it is to let your glioma tissue provide you with its own characteristics, so that these features can be extracted to make antigens, and then if once you **, you can carry out extremely accurate removal of glioma stem cells on your own. Industry experts include Dai Yiwu, Qin Jiazhen, etc., Dean Dai went to the clinic on Tuesday morning (but Expert Qin went to the clinic on Wednesday afternoon) in the expert clinic on the first floor of the Bayi Brain Hospital affiliated to the General Hospital of Beijing Military Region.