What causes restless legs, what causes restless legs

Restless legs syndrome is divided into two types: primary and secondary, and primary restless legs syndrome may be related to genetics. The causes of secondary restless legs syndrome are very varied, including spinocerebellar ataxia, peroneal muscular atrophy, Parkinson's disease, iron deficiency anemia, uremia, pregnancy, etc. The pathogenesis of restless legs syndrome is not well understood, and there are several hypotheses:

1. Genetic factors, about 50%-90% of patients with primary restless legs syndrome have a positive family history, which is autosomal dominant inheritance. 2. Iron deficiency, studies have shown that patients lack iron in their bodies, and iron supplementation is effective for some patients. 3. The central hypothesis, most of them believe that the excitability of the central nervous system and amino acids have an excitatory effect, which may be an important reason for patients.

Restless legs syndrome may be related to genetic factors, among other things. Restless legs syndrome is mainly manifested in a resting state and is more common during sleep. Indescribable paresthesias in both lower limbs, such as burning, ant crawling, etc., usually require strenuous movement of the legs to relieve symptoms.

Primary restless legs syndrome may be related to genetic and cerebral dopamine dysfunction. Secondary restless legs syndrome can be caused by a variety of diseases, such as chronic renal failure, polyneuritis, rheumatoid arthritis, Parkinson's disease, etc. In addition, hemodialysis and the use of specific drugs can also cause secondary restless legs syndrome.

Patients should pay attention to daily work and rest, and increase rest time appropriately. Don't drink too much strong tea before going to bed and avoid excessive sleep during the day to reduce sleep disturbances.

The cause of the disease is unknown. It is often complicated by gastric surgery, uremia, alcoholism, and psychiatric factors are of certain importance to the pathogenesis.

In particular, symptoms occur when conceiving, watching movies, and plays. It is thought to be autonomic dysfunction. Infectious diseases, vitamin deficiencies, diabetes mellitus and various anemias may be the most important factors.

It is thought to be an autosomal dominant disorder that can occur in several people in the same family.

The use of phenylthiazide has been mentioned, and abrupt discontinuation of barbiturates can precipitate the disease. Some believe that the most likely cause is an abnormal build-up of metabolites in the muscles. It has also been reported to be associated with inadequate CAPD (peritoneal dialysis) or impaired local circulation.

There are two types of diseases: primary and secondary. Among them, the primary ** is unknown, and children often have a family history of heredity. Secondary is common due to the following causes:

Uremia, iron deficiency anemia, folate deficiency, pregnancy, rheumatoid arthritis, Parkinson's disease, multifocal neuropathy, metabolic disorders, and drugs.

Restless legs syndrome is complex and unknown in Western medicine, and the following factors are thought to be related to the onset.

1.Genetic factors.

Ekbom (1960) suggested that the pathogenesis of RLS was genetically related, with 43% of the reported patients having similar disorders in their relatives, and several families were dominantly inherited.

2.Doctrine of ischemia.

RLS usually occurs during quiet rest, but it can also occur during long-term work in cold environments, and symptoms are often relieved by activity, compression, thrashing of local muscles, or the use of vasodilators. In some patients, limb blood flow studies also show decreased blood flow. Based on the above facts, many scholars believe that this disease is caused by local tissue blood circulation disorders, resulting in tissue hypoxia and metabolite accumulation.

3.Endocrine factors.

RLS is also common in pregnant women. Retrospective diagnosis was made in 486 newly born women and the disease was found. Jolivet (1953) reported that 27% of pregnant women had RLS.

4.Metabolic and nutritional disorders.

Severe RLS is mostly complicated by diabetes, uremia, ethanol poisoning, cancer, hypercholesterolemia and hematoporphyria, so it is thought that it may be metabolic peripheral neuropathy caused by metabolic disorders. It is also thought to be associated with anemia and iron deficiency. Among the 77 patients with the disease reported by Ekbom (1966), 1 4 serum iron was below normal; Aspenstrom (1964) reported that 42% of the 80 patients with iron deficiency identified on health examinations had RLS; Behrman (1955) confirmed that patients with this disease felt significantly better after oral or injected iron supplements.

5.Other**.

Partial venous thrombosis and varicosis of the lower extremities, partial gastrectomy, use of phenothiazines and barbiturates, and psychiatric factors such as anxiety or depression have been reported to be related to the disease.

Restless legs can be caused by malnutrition or by a weakened immune system. In addition, the possibility of folic acid or vitamin deficiency is not ruled out.

The cause of primary restless legs syndrome is often unclear and may be genetic; Secondary restless legs syndrome is often associated with a variety of disorders or drug use.

Essential**. Primary restless legs syndrome.

May be related to genetics, abnormal dopamine function in the brain.

Secondary restless legs syndrome.

Many diseases can lead to restless legs syndrome, such as chronic renal failure, polyneuritis, rheumatoid arthritis, Parkinson's disease, Sjögren's syndrome, iron deficiency anemia, folate and vitamin B12 deficiency, etc., in addition, hemodialysis, history of use of special drugs, etc.

Predisposing factors. Poor living conditions, malnutrition, weakened immunity, pregnancy, etc. can all induce restless legs syndrome.