What does premature ovarian failure mean and what is premature ovarian failure?

Premature ovarian failure (POF) refers to ovarian failure before the age of 40 due to a variety of **, with an incidence of more than 1% in women of childbearing age, and the incidence rate has increased and become younger in recent years, which is considered to be an "incurable disease" that leads to infertility. Sun Haixiang, director of the Reproductive Medicine Center of Nanjing Drum Tower Hospital, told reporters that patients with premature ovarian failure are difficult to conceive even through assisted reproductive technology due to ovarian failure, because such patients do not have dominant follicular activity in the menstrual cycle and cannot obtain eggs.

With the support of the Chinese Academy of Sciences Stem Cell and Regenerative Medicine Research Pilot Project, the Center for Reproductive Medicine of Nanjing Drum Tower Hospital and the Dai Jianwu Regenerative Medicine Research Team of the Institute of Genetics and Development of the Chinese Academy of Sciences took the lead in carrying out the clinical study of umbilical cord mesenchymal stem cells in the intervention of premature ovarian failure and infertility in 2015. After passing the hospital ethics review and the filing of the National Health and Family Planning Commission, the clinical research became one of the first eight stem cell clinical research projects to be filed after the implementation of the stem cell clinical research filing system in China, and was officially launched in Nanjing Drum Tower Hospital.

According to the relevant person in charge of Drum Tower Hospital, in December 2015, the clinical team of Professor Sun Haixiang of the Reproductive Center of Nanjing Drum Tower Hospital carried out stem cell intraovarian transplantation for Ms. Fang, and the umbilical cord mesenchymal stem cells were prepared by the GMP-level clinical stem cell room of Drum Tower Hospital and tested by the third party of China Institute for Food and Drug Control. After the postoperative examination, the ovarian blood flow improved significantly, and Ms. Fang underwent two more transplants in 2016. In May 2017, Ms. Fang was confirmed to have large follicles after examination, and she achieved natural conception in the same month.

In the past two years, 23 patients have been enrolled in the clinical study, and follow-up has found that 9 patients have dominant follicular activity, 2 patients have obtained clinical pregnancy, and another 2 patients have obtained transferable embryos and are preparing the endometrium for transfer.

Premature ovarian failure refers to the phenomenon that amenorrhea, ovarian atrophy, low estrogen levels in the body, and gonadotropin levels reach menopausal levels before the age of 40 after puberty. The pathogenesis is abnormal karyotype, follicle production disorder, autoimmune ovarian failure, and too little or too much egg reserve.

The pathological types include non-follicular and follicular type. Patients with nonfollicular type have abnormal chromosomal karyotype, ovarian hypoplasia, and no follicles in the cortex. Patients often require small amounts of estrogen, or estrogen and progestin cycles**, to eliminate menopausal syndrome and prevent osteoporosis.

Premature ovarian failure refers to women with regular menstruation, before the age of 40, due to the decline and decline of ovarian function, resulting in ovarian atrophy persistent amenorrhea and sexual organ atrophy, Kyushu said that there is no ovulation, and the secretion of estrogen is reduced.

What parents should know is premature ovarian failure.

The three main sources of premature ovarian failure are excessive pressure, excessive ** and long-term cold of the body.

Premature ovarian failure can affect pregnancy. Premature ovarian failure refers to the corresponding pathological changes in basal endocrine, follicle-producing hormone, luteinizing hormone, and estradiol, and the impact of premature ovarian failure on pregnancy is mainly manifested in the following two aspects:

1. The number of follicles is small; Premature ovarian failure will affect the growth and development of follicles, and even the appearance of petrification of the ovaries will occur, that is, the ovaries can no longer see the follicles, which is almost impossible to get pregnant. Even if some patients have a small number of egg cells remaining in the ovaries, the natural pregnancy rate is low, only about 5%-15%.

2. Poor follicle quality; Premature ovarian failure not only leads to a decrease in the number of follicles, but also leads to an insufficient number of available follicles, and there are certain problems with their quality. Even after drug conditioning, ovulation induction, etc., it is possible that the follicles will not be able to develop and mature, and in this case, there is no way to get pregnant.

Premature ovarian failure generally refers to the decline of ovarian function in women before the age of 40. Decline in ovarian function is an irreversible change.

If there is a need for fertility, oral peryl can be used with vitamin E to delay the decline of ovarian function and promote the release of eggs to achieve the purpose of pregnancy. Epidemic prevention and control is still recommended to buy a certain bao.

Pay attention to a light diet in daily life, eat more soy products, and maintain a happy mood.

Premature ovarian failure is characterized by a decrease in estrogen levels, which is an endocrine disorder. Premature ovarian failure is the appearance of menopausal symptoms at an age that is not menopause, manifested as gradual aging, menstrual disorders or menopause, which are the main reasons for patients to go to the doctor. The six tests showed a significant decrease in estrogen levels.

To be clear, premature ovarian failure usually cannot, however, oral medication can be used to supplement estrogen to maintain the balance and stability of sex hormone levels, improve the body's hormone levels, maintain a normal state, avoid the symptoms of premature aging, and improve the quality of life.

Premature ovarian failure is a phenomenon of premature ovarian aging in female friends, and normal female friends will gradually move towards an aging process after the age of 40. Endocrine disorders are mainly caused by the decrease of estrogen, and once the endocrine disorder occurs, it will indirectly lead to premature ovarian failure. Patients should develop good eating habits, eat more fresh fruits and vegetables, eat more high-protein foods, drink more water, replenish the water needed by the body, and participate in various sports to enhance physical fitness.

Premature ovarian failure is caused by endocrine function, which is manifested in insufficient estrogen secretion and a series of external conditions. This can be adjusted through the usual diet and traditional Chinese medicine.

What parents should know is premature ovarian failure.

Premature ovarian failure can lead to abnormal estrogen secretion in the body, which can seriously lead to infertility, and it is recommended to have children as soon as possible.

1. Greedy for cold and cold.

In fact, the root cause of premature ovarian failure in most young women is uterine cold, and the occurrence of uterine cold is directly related to women's excessive greed for cold in their daily life. For example, some women like to eat cold food in the hot summer, and even some women eat ice cream in the winter; There are also some young women who like to turn the temperature very low in the air-conditioned room, and the cold wind will cause the palace cold for a long time, and there are also some women who wear too thin clothes in the cold winter, like to wear crop tops and ankles, which will cause uterine cold and damage the health of the ovaries.

2. Unhealthy lifestyle.

Many white-collar women in life are under tremendous mental pressure, and if they are often emotionally depressed, it will affect the balance of hormone secretion, which will lead to premature ovarian failure.

In addition, many young girls have developed a lot of bad living habits, such as staying up late and working overtime, abusing ** products, and lack of exercise, which will cause great damage to women's ovaries and cause premature ovarian failure.

There are also some women who do not do a good job of contraception and have undergone ** surgery after an unplanned pregnancy, which causes serious damage to our ovaries and uterus.

3. Improper diet.

Improper diet is also an important cause of premature aging in young women, for example, some women rarely eat soy products in their usual diet, excessive consumption of dairy products, fried and puffed, high-fat foods, and long-term improper diet can exacerbate premature ovarian failure to a certain extent.

What parents should know is premature ovarian failure.

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What parents should know is premature ovarian failure.

Between the ages of 45 and 50, menstrual bleeding is significantly less heavy, possibly due to premature ovarian failure.