Ibuprofen has side effects, what are the specific aspects?

Ibuprofen is a pain-relieving pill, if taken for a long time, there is a possibility that the following ***: First, the digestive system will be affected. Second, there may be neurological problems such as headaches, tinnitus, and drowsiness.

Third, it will affect kidney function. Fourth, bronchial diseases, rashes and other conditions, as well as visual impairment, allergic reactions, etc.

It can cause diarrhea, even affect liver function, and also cause stomach pain and stomach ulcers. Regular use can also cause drowsiness, dizziness and tinnitus. Bronchial asthma, visual impairment occurs.

% Gastrointestinal adverse effects, including dyspepsia, stomach burning, stomach pain, nausea, and vomiting in long-term use. Neurological adverse effects such as headache, drowsiness, dizziness, and tinnitus may occur in 3% of patients. 3. Rare adverse reactions include lower limb edema, renal insufficiency, rash, bronchial asthma, abnormal liver function, leukopenia, etc. 4. Bone marrow suppression and liver function damage in high doses.

5. When used with heparin and oral anticoagulants, there is a risk of increased bleeding. 6. When used with furosemide, the antihypertensive effect of the latter is weakened. 7. When used with verapamil, nifedipine and probenecid, the blood concentration of ibuprofen increases.

Ibuprofen is generally manifested as adverse reactions of the digestive tract, including indigestion, stomach burning, stomach pain, nausea, and vomiting, and a small number of patients can have headache, drowsiness, dizziness and tinnitus and other neurological adverse reactions.

The main manifestations are dizziness, headache, nausea, vomiting, indigestion and drowsiness, as soon as these conditions occur, the use of ibuprofen should be stopped.

It can cause headaches, indigestion, nausea and vomiting. Moreover, long-term use can also cause liver and kidney function to be impaired.

Ibuprofen was discovered by Dr. Stewart Adams (who later became a professor and was ordained an OBE) and his team, scientific expert Cokin Burrows, and chemist Dr. John Nichokson.

Ibuprofen is the product of long-term research in the 50s and 60s of the 20th century, during the development of ** "super aspirin" for rheumatoid arthritis. Calling ibuprofen a "super aspirin" meant that it was just as effective as other drugs at the time, but safer. In 1964, when disappointing results in clinical trials of several promising compounds were discovered, ibuprofen was selectively developed, which had a relatively short half-life and was well tolerated by the gastrointestinal tract.

Ibuprofen was marketed in the United Kingdom in 1966 and in the United States in 1974. In 1983, ibuprofen became the first non-steroidal anti-inflammatory drug (NSAID) to be sold over-the-counter in the UK, and the following year (1984), ibuprofen became an over-the-counter drug in the US. Ibuprofen is a non-selective cyclooxygenase (COX) inhibitor, and recent evidence suggests that its anti-inflammatory properties are achieved by modulating leukocyte activity, reducing cytokine production, inhibiting free radicals, and signaling.

Ibuprofen may also exert a central analgesic effect through the dorsal horn, and its potential applications may also include a protective effect in certain cancers and Alzheimer's disease Alzheimer's disease.

Ibuprofen inhibits cyclooxygenase in the human body, reduces the synthesis of prostaglandins, and produces analgesic and anti-inflammatory effects; It has an antipyretic effect through the hypothalamic thermoregulatory center. Ibuprofen capsules are commonly used for the following conditions:

Relieves mild to moderate pain such as headache, arthralgia, migraine, toothache, muscle pain, neuralgia, dysmenorrhea, etc.

It has an antipyretic effect on fever and can be used to reduce fever, such as fever caused by the common cold or epidemic.

The principle of ibuprofen is due to the effect of ibuprofen on inhibiting the activity of the hypothalamus, thereby reducing the synthesis of prostaglandins. When prostaglandins are reduced, they can speed up the rate of heat dissipation, which can play a cooling role. It can be seen that its fever-reducing function is very powerful, and many people in Li Ku are very willing to choose this medicine after they have a fever.

Ibuprofen is not only a fever reducer, but it is also a very good pain reliever. It can be said that it is a necessary medicine for every family, and will eating too much of this drug have adverse effects on the body?

I think you must have seen a news story some time ago that you had liver problems after taking several different fever-reducing medicines for two days. We can't blindly take any medicine, and we must use the pills according to the doctor's instructions, and we must not rely on our own feelings. This will definitely be risky, and the consequences are more serious, ibuprofen is almost a must-have drug in every family, many people may also have a certain dependence on him, especially some people who are more painful during the menstrual period, may be very overly dependent on this painkiller.

I think everyone must try to reduce their dependence on this drug, because long-term dependence on this drug will cause pain in your body, and you can't help but want to take a tablet. However, long-term use of this painkiller can also affect your body.

Whether ibuprofen is used as a fever reducer, medicine or other antipyretics, it has a certain effect on the body. This requires us to pay more attention to our physical health and minimize the probability of getting sick. In normal times, we must strengthen physical exercise, so that we can consider enhancing our body's immunity and reducing our risk of disease.

At the same time, we must also ensure enough sleep, and now most people's lives are also very problematic, which is also the main reason for the decline of the body's immunity. In addition, we should also pay attention to adjusting our diet structure and try to keep our diet comprehensive and nutritionally balanced.

This process starts in your digestive system. Within a few minutes, the drug begins to be broken down by stomach acid in the stomach.

The dissolved ibuprofen enters the small intestine and then through the intestinal wall into the vascular network. These blood vessels lead to a vein (hepatic portal vein), which carries blood into the liver.

When ibuprofen passes through the blood vessels of the liver along with the bloodstream, enzymes in the liver try to react with the ibuprofen to render it useless. Damaged ibuprofen molecules, called metabolites, no longer have the effect of painkillers.

At this stage, most of the ibuprofen passes through the liver unharmed. It then continues through the veins to leave the liver and enter the body's circulatory system.

Half an hour after you swallow the drugs, some of them have entered the bloodstream. These blood vessels pass through the limbs, heart, brain, kidneys, and back to the liver.

When ibuprofen molecules travel through this circuit to a place where pain is very intense, they bind to specific target molecules in this pain response, and painkillers like ibuprofen block the synthesis of substances that help send pain signals. The more drug molecules accumulate at the pain point, the better the pain relief will be, and this effect will peak within one to two hours after swallowing the painkiller.

Then, the body begins to remove ibuprofen effectively, and on average, the concentration of this drug in the blood is halved every two hours.

When the ibuprofen molecule separates from the specific target molecule, the blood system will also carry the ibuprofen molecule away again. After returning to the liver, a small fraction of the total amount of the drug is converted into metabolites, which are finally filtered out by the kidneys and incorporated into the urine.

The circulation from the liver to the body to the kidneys is carried out at a rate of about once per minute. In each cycle, part of the drug is broken down and eliminated from the body.