The rabies vaccine is a few minutes away from the ice, so will the vaccine inside die?

29.What are the dangers of the vaccine not being stored at the prescribed temperature?

The instructions for use of rabies vaccine stipulate the storage temperature (2 8), which has been tested and proved to be stored within this temperature, and the vaccine efficacy is relatively stable. As the temperature rises, the active ingredient of the vaccine, glycoprotein antigens, will break down faster, and the potency will be reduced. In order to increase the stability of the rabies vaccine, adjuvants are added to the vaccine to play a certain stabilizing role.

In a short period of time, if you buy the vaccine and go home for a short time (put it in a dark, cool, and ventilated place), if the temperature exceeds the specified temperature, the impact is not very large. When you get home, you should put it in the refrigerator (because it takes a month to get five doses of the vaccine). If there is really no refrigerator in the countryside to store it, it is best to put it in a nearby unit with a refrigerator and go to the health unit on time to inject it.

The vaccine should not be frozen, and after freezing, the rabies vaccine will also be ineffective, and the preventive effect will not be achieved.

30.What are the factors that affect the effectiveness of the rabies vaccine?

The transportation and storage temperature of the vaccine directly affects its efficacy, and the efficacy of the vaccine decreases faster beyond the specified storage temperature. Over time, it can even render the vaccine ineffective. Freezing can also render vaccines ineffective.

If the ampoule is opened without sufficient shake of the vaccine before use, the antigen trapped on the top of the ampoule will be lost or the vaccine will leak out during injection, resulting in an insufficient dose of antigen injected.

Associated with the first dose of the vaccine sooner or later: the vaccine is more effective if given within 24 hours of the bite. Therefore, the injection should be started 48 hours or later, and the first dose should be doubled.

The sequence of anti-rabies serum and rabies vaccine injection also has an effect: if the anti-rabies serum is injected on the first day and the vaccine is injected on the next day, the antibody response of the vaccine will also be affected, so the first dose will also need to be doubled.

The injection site is related to the strength of the antibody response: the effect of the vaccine injection into the deltoid muscle of the upper arm is better than that of the buttocks, and young children can be injected into the anterolateral thigh muscles, but not the buttocks.

The immune effect of the first dose of vaccine is positively correlated with the amount of antigen injected and the number of injection sites, so for eight types of people including seriously injured patients, the first dose of vaccine needs to be doubled and injected into the deltoid muscles on both sides, and the effect is better.

What else do you have to worry about when you own a dog, unless the dog is not clean, and it is very playful, likes to contact with strange dogs or likes to stay in the grass, besides, you are relieved that the injection will be given after three years, and you are worried about whether it will work.

The rabies vaccine will definitely be inactivated four hours after it is taken out of the refrigerator! The storage condition of rabies vaccine is 2-8 degrees Celsius, and the storage condition cannot exceed half an hour, otherwise the vaccine will lose stability and must be scrapped.

In reality, dogs, cows, sheep, horses, etc. may carry rabies virus, even rabbits, so if they are bitten or scratched, they must be vaccinated against rabies. In principle, you should go to the vaccine on the day you are bitten, don't miss the best time of 24 hours, once you get sick, it is very difficult.

For those who miss the optimal 24-hour period, they can be refilled, and the dose of the first two injections should be doubled. The injection process is divided into 5 injections, which are the 1st day, 3rd day, 7th day, 14th day, and 30th day, a total of 5 times. If the bite is particularly severe, the first and third injections should be doubled.

Rabies serum is added to the first shot.

It should be noted that anyone who uses serum must take 2-3 more injections after 5 injections, and if you choose to get 2 injections, you must take 2 injections on the day after 5 injections. If you choose 3 injections, you need to inject them 3 times. In addition, on the 15th day after all the injections have been completed, you have to go to the hospital to check whether there is an anti-Wu liquid song bend in the body, if you have it, it is the best, if not, you need to inject another 1-2 times of vaccine until the antibody is detected.