What causes retinoblastoma?

Retinoblastoma is an intraocular malignancy caused by mutation or deletion of the tumor suppressor gene RB1, which is divided into hereditary and non-hereditary types

1. The genetic type accounts for about 40% of retinoblastoma, which is caused by the child's parents being carriers of mutant genes or normal parents with germ cell mutations, which is autosomal dominant inheritance. About 10% of 15% of children have a definite family history of retinoblastoma.

2. Non-hereditary types account for about 60% of retinoblastoma and are caused by genetic mutations.

Retinoblastoma is a malignant tumor that is commonly seen in infants. The incidence of malignant tumors in children is in the first place, and the cause of retinoblastoma is not well understood. However, according to most research protocols, half of the chance of retinoblastoma is determined by genetics, and the other half is caused by gene mutations, the gene that causes retinoblastoma, according to the study is located on chromosome 13q14, and the gene mutation chromosome is also located on chromosome 13, but the mechanism of the specific mutation is not completely clear.

Retinoblastoma is mainly based on early diagnosis, early diagnosis may preserve the eyeball, may also retain part of the vision, so retinoblastoma infants, early infant screening is very important, it is recommended at 2 months or 4 months, 6 months, to carry out newborn eye health screening, it is possible to detect retinoblastoma early, and then carry out early**.

This is more common in children and is the presence of poorly differentiated cells in the fetus.

The description of retinoblast mydochroma is incorrectly called ()aEarly symptoms are a "cat's eye" sign, which manifests as leukopupilism.

Presents as a polyp-like or nodular soft-tissue mass within the eyeball with irregular margins and uneven density.

c.Calcifications are common in tumors.

d.Calcifications are occasionally found in the tumor.

e.Contrast examination of the lesion is mild to moderate enhancement.

Correct answer: d

Intrabulbar localized high-density mass, the mass is connected to the eye ring;

Irregular calcifications are common in the mass, showing a homogeneous or heterogeneous distribution;

In some cases, both eyes may be affected, and the advanced sliding hall tumor may spread to the orbit or other parts of the body.