Does the deletion of a base pair upstream of the coding region of a gene cause a mutation in the cod

Synthesize the previous ones.

Does the deletion of a base pair upstream of the coding region of a gene cause a mutation in the coding sequence? Not a mutation. So it won't.

That is, the subsequent bases are shifted forward, and even several genes in the non-coding region will become coding sequences? The problem of ticking only occurs in the coding area.

When DNA is transcribed, transcription factor (primer?) ) will recognize a fixed starting point. If the deletion of the upstream base encoding is not at this starting point, then the subsequent sequences do not change at all.

If the base is missing at this point, transcription may not begin. The entire gene cannot be expressed. At best, the efficiency of transcription changes. This is not called a mutation, this is called a regulation error.

This may result in the transcript becoming longer, but it is usually spliced off in the RNA.

The greatest effect of upstream primer deletion is the possible alteration of the transcriptional activity of the gene.

Probably not, but it may have an impact on the regulation of genes.

Yes. Genes are coded as one per 3.

Missing one will completely scramble the encoding.

Genetic mutations occur, but not genetic mutations

By the definition of a genetic mutation, this is possible.

1. The structure of genes includes coding and non-coding regions. Whereas, the coding regions of genes in eukaryotes are discontinuous and include exons and introns. Exons are valid coding sequences within the coding region, and introns are non-coding sequences within the coding region.

Both can be transcribed into RNA (hnRNA, to be exact), which is then cut out by RNA processing mechanisms to become mature mRNA and only exons remain. The coding regions can be transcribed into RNA, the non-coding regions cannot be converted into RNA, and large swaths are waste products, some of which have important regulatory roles.

2. The coding region is a DNA sequence to be expressed, and the non-coding region is not expressed, exons and introns are present in eukaryotic cells, exons are the sequences to be expressed, and introns are not expressed sequences, which are arranged at intervals.

It is the exons that code for proteins, while introns have no coding function.

Introns are present in DNA, and during transcription, the introns on the DNA are also transcribed into the precursor RNA, but the introns on the precursor RNA are excised before the RNA leaves the nucleus for translation.

A change in the base sequence of a gene is a gene mutation, and a gene mutation does not necessarily lead to a change in traits.

The main reasons are:

1) If the mutation occurs in the intron of the eukaryotic gene structure, the mRNA transcribed by this gene remains unchanged, so the synthesized protein does not change, and the trait does not change.

2) If the codon on the mRNA is changed after the mutation occurs, but because one amino acid can correspond to multiple codons, if the changed codon and the original codon still correspond to the same amino acid, the trait controlled by the mutant gene will not change. (3) If the gene mutation is a recessive mutation, such as one of the A genes in AA is mutated into a gene, the trait does not change at this time.

A change in the base sequence of a gene means that the gene has been mutated. Gene mutations may also change the base sequence of the mRNA, but it does not necessarily cause the amino acid sequence of the protein to change, that is, the trait does not necessarily change.

Hope it helps!

Because codons are degeneracy, the codons of mRNAs transcribed after a change in gene base sequence may correspond to the same amino acids, so they do not necessarily lead to a change in traits.

Coding region: A piece of DNA sequence that can encode a synthetic messenger RNA that directs protein synthesis.

Non-coding region: Unable to transcribe rollover to the corresponding messenger RNA and to direct protein synthesis. The non-coding region is located before and after the coding region and belongs to the same gene, which controls the expression and strength of the gene. The promoter belongs to the non-coding region.

The coding regions of prokaryotic genes all encode proteins.

The coding of eukaryotic genes is divided into exons and introns, and only exons can code for proteins.

There are also exceptions to the genes of eukaryotic eukaryotes without introns. Histone genes and interferon genes do not have introns. The coding region is an efficient gene fragment encoding a protein; The non-coding region does not code for proteins.

Extension: Exon: A fragment of the Yu Yu gene encoded for a polypeptide. Intron: A fragment of a gene that does not code for a polypeptide.

Mutations in genes that do not alter the encoding amino acids are as follows: synonymous mutations.

Substitution of base pairs. Due to the degeneracy of codons, an amino acid can have multiple codons to encode it, and the substitution of base pairs that occurs when a gene mutation occurs usually has minimal effect on translation and does not result in a change in the amino acid sequence.

By analyzing the effects of different gene sequences on protein amino acid sequences, the effects of shed deficit changes in gene sequences on human characterization and diseases were analyzed. This mutation is called a synonymous mutation.

In a polypeptide expressed by a gene, an amino acid abnormality is found, and the mutation mode of the gene is missense mutation.

A missense mutation is a mutation in DNA that causes a codon in the mRNA to change to encode another amino acid. Missense mutations produce false codons, resulting in gene mutations that may alter the outcome of gene expression. Synonymous mutations do not, the codon still encodes the same protein.

Missense mutations can lead to changes in the amino acid sequence of the peptide product or a change in the functional RNA base sequence, which may have no effect on the expression product and may be beneficial, but most are deleterious or lethal.