What causes the onset of ankylosing spondylitis

Ankylosing spondylitis is mainly a chronic disease that invades the joints. Hello guidance, the cause of ankylosing spondylitis is not very clear, many people are genetic, in genetic statistics, heredity accounts for a large part, it is recommended to go to the hospital for relevant examinations.

Obligatory spondylitis is a seronegative spondyloarthropathy. The onset is often insidious, generally in young and middle-aged people between 30 and 50 years of age, and morning stiffness and back and hip pain can occur, which can lead to loss of spinal mobility. A clinical feature of ankylosing spondylitis is that patients often wake up at night with back pain, which is relieved by light activity.

In addition, clinical manifestations include asymmetric peripheral arthritis and, rarely, cardiac and pulmonary involvement.

The causes of ankylosing spondylitis are as follows, the first is genetic predisposition, ankylosing spondylitis is a highly hereditary disease. Studies have shown that HLA27 is directly involved in the pathogenesis of ankylosing spondylitis, and in addition to HLA27, other HLA1 molecules, such as B60 and Class 2 molecules, may also be involved in the pathogenesis. The second aspect is environmental factors, which may be ubiquitous, among which Bacillus pneumoniae granules may be one of the candidate factors, and microorganisms may act through the intestine, because more than 60% of patients with ankylosing spondylitis have subclinical inflammation of the intestine, which causes immune disorders in the body under the factors of genetic predisposition and exogenous induction, which leads to the occurrence of mandatory spondylitis.

The main symptoms of ankylosing spondylitis are actually divided into two parts, one is axial symptoms and the other is peripheral symptoms. The central axis refers to the entire spine, mainly starting with the sacroiliac joint, and then the earliest manifestation is inflammatory low back pain, which is the manifestation of sacroiliac joint involvement. If it is not timely, it will gradually develop upward, and finally after the entire spine is inflamed, there will be bamboo-like changes, which is the central axis change.

Peripheral changes mainly include several aspects, one is peripheral arthritis, uveitis, iritis, and wax finger, and some patients may have ** manifestations, mainly psoriasis, and some will have intestinal manifestations, that is, inflammatory bowel disease. In general, ankylosing spondylitis is mainly an inflammatory disease with peripheral symptoms.

Although it is because the usual behavior habits are not particularly good, and secondly, because of the frequent inactivity and maintaining a posture, it will cause certain harm to the spine and cause spondylitis.

It is because of often maintaining a posture, but also because you don't pay attention to your physical condition, don't move much, and have problems with diet and rest habits.

Environmental factors, genetic factors, self-factors, low autoimmunity lead to infection, perennial fatigue, and high stress.

In this case, it is likely to be caused by genetic factors, or it may be caused by various factors such as environmental factors.

Hello, living in a humid and cold area has a higher chance of suffering from the disease than normal people, so patients should avoid living in this harsh environment for a long time, windy, cold and humid environment is the main cause of the disease, especially in winter, you should pay attention to the warmth of the body, which can reduce the incidence of the disease to a certain extent. At the same time, genetics, trauma, postpartum and other factors can lead to the occurrence of anatomy, it is recommended to go to a regular professional hospital to check, find, standardize the use of drugs, symptomatic, do not blindly use drugs, blindly, choose the right scientific method.

Ankylosing spondylitis belongs to the category of rheumatology and immunology, which has genetic infections, immune system disorders and other causes, as well as environment, overwork, and postpartum rigidity, which can lead to AS

Ankylosing spine.

Inflammation is a disease characterized by inflammation of the sacral iliac joints and spinal entheses. It is an autoimmune disease, and although it has been studied by many scholars, it is not clear that it may be related to the following factors:

1 Genetic factors: The incidence of the disease varies greatly among different ethnic groups, with the incidence in Native Americans in North America and only in Africa. The ratio of incidence between whites and blacks in the United States is:

1。According to surveys, the incidence rate among relatives of ankylosing spondylitis patients is about 3o times higher than that of the general population. Some studies have found that ankylosing spondylitis has a stronger familial genetic predisposition than rheumatoid arthritis.

This suggests that genetic factors play a decisive role in the disease. Someone has counted 100 patients with ankylosing spondylitis, and the positive rate of HLA-B27 is 88, and 15 cases have a family history, including 11 cases of father and brother suffering from the same disease.

2 Infectious factors: After a lot of observation, some scholars have found that many male patients with ankylosing spondylitis have prostatitis. In addition, some studies have found that the incidence of ulcerative colitis and localized enteritis is higher in patients with this disease than in the general population, leading to the hypothesis that the causative homogeneous may be an infection.

3 Other a** substances; These include viral infections, trauma, thyroid disease, tuberculosis, local infection, etc., but there is a lack of sufficient evidence.

To sum up, there is no theory that can explain the whole of ankylosing spondylitis, and it can only be thought that it may be based on genetics, plus the influence of infection and other aspects.

Hello, ankylosing spondylitis is an autoimmune disease, and the cause of its onset is not very clear, but it can be related to factors such as the background of the posthumous transmission, the living environment, and the infection of viruses and bacteria. This disease can also be very good, to use etoricoxib tablets anti-inflammatory and analgesic**, slow-acting anti-rheumatic drugs such as sulfasalazine, thalidomide and other long-term**, conditions allow the use of biological agents such as Enli**. After the condition is stabilized, it is necessary to pay attention to appropriate exercise, for this disease, exercise is also a kind of **, you can swim, yoga, jogging, etc.

AS is a chronic inflammatory, progressive, and self-limited accommodating disease that begins with the opening of the sacroiliac joint, mainly invades the sacroiliac joint, spine and hip joint, and spinal rigidity and flexion deformity occur in the affected spine department, the exact ** is unknown, but it is related to infection, genetics, dampness and cold, autoimmune dysfunction, and other factors. AS is a systemic disease dominated by chronic inflammatory lesions of axial joints, which belongs to seronegative spondyloarthropathy. The prevalence is around.

Ankylosing spondylitis mainly affects the sacroiliac joints, causing stiffness and fibrosis of the spine, causing bending over immobility, and can have varying degrees of damage to multiple organs such as eyes, lungs, cardiovascular, and kidneys.

Common symptoms include low back pain, which is often dull. As the lesion progresses, symptoms gradually worsen, and chest pain may occur, chest expansion is limited, and it is difficult to lower the head, lean back, and turn the neck from side to side. In severe cases, it is difficult for the patient to turn over.

People don't want to be threatened by ankylosing spondylitis, which is very harmful to people and needs to be treated well. However, because people do not understand it, there is no way to prevent it from happening. Below, let's take a specific look at it, and we must help people's health well.

Nowadays, ankylosing spondylitis is a common disease in life, and its arrival seriously affects people's quality of life and physical and mental health. In this regard, once the disease is discovered, it should be timely** to better protect your health. First of all, it is necessary to understand, which is more helpful.

So, here are the ** of ankylosing spondylitis. 1. Autoimmune causes: In recent years, expert studies have found that the lymphocyte histocompatibility antigen (HLA-B27) in patients is high after the disease, and only a few patients with ankylosing spondylitis have elevated immunoglobulin, and immunosuppressants are effective in this disease, all of which support that this disease is an autoimmune disease.

2. Cause of infection: In some clinical studies on ankylosing spondylitis in recent years, it has been found that the prevalence of ankylosing spondylitis may be related to infection. Genitourinary infections are important in ankylosing spondylitis**.

The infection spreads from the prostate and seminal vesicles through the lymphatic system to the sacroiliac joints and pelvis, and then spreads into the systemic circulation, causing systemic symptoms and lesions in the surrounding joints, tendons, and uveas. 3. Genetic causes: Since some studies have found that patients with ankylosing spondylitis have ankylosing spondylitis patients in the patient's family, it shows that familial hereditary properties are indeed related to the onset of ankylosing spondylitis.

Since the HLA system, like blood group antigens, is genetically determined, it is one of the important factors in inheriting the disease. The above is an explanation of what has been made, and people may have a clear understanding of it, hoping that this will make people better away from the threat of ankylosing spondylitis. In order to avoid the disease causing more harm to patients, you must be timely**, do not miss the best ** time, I hope the above can help you, I wish you good health.

Ankylosing spondylitis is not a hereditary disease in the medical community, 90% of AS patients have genetic factors, but the cause of the disease is not genetic factors, heredity only indicates that the incidence of compulsory spondylitis is more likely to occur. Clinical studies have found that the serious disease of ankylosing spondylitis is closely related to the imbalance of the body's immune system, and immune dysfunction is the internal environment of the disease. Inflammation and erosion are also one of the triggers for the onset of the disease, and infections of various organs can also lead to the onset of ankylosing spondylitis.

Living and working in a dark, damp and cold environment will lead to inflammation of the synovium, ligaments and cartilage of the joints, causing joint swelling and pain, leading to joint dysfunction and the onset of ankylosing spondylitis.

My brother and daughter-in-law are ankylosing spondylitis, and when she was in the North Asia Orthopaedic Hospital**, she also asked Director Li Fushun, what are the causes of ankylosing spondylitis? Director Li said that the causes of ankylosing spondylitis are very complex, and the most common causes are genetics, infection, humidity in the environment, and it is related to taking hormone drugs regularly. I hope you can pay attention to the above points, I hope it can help you!