How to make an interpretation of the Down Syndrome screening report, the examination report of the D

Judging from the data of the test list, it is low-risk, but the current general serological Tang screening has great shortcomings, the accuracy rate is not very high, and the false positive rate is also very high. Invasive tests such as amniocentesis carry a high risk and can lead to miscarriage.

Therefore, it is recommended that if the landlord is not at ease, he can try non-invasive prenatal genetic testing, and only need to draw about 5ml of the mother's venous blood, with an accuracy rate of more than 99%. At present, there are mainly Beijing 301 Hospital, Chongqing Southwest Hospital, Guangzhou Nanfang Hospital, Nanjing Women and Children, Wuhan Women and Children, Shenzhen Second People's Hospital and other more than 10 hospitals can do this test, they are all in cooperation with Shenzhen BGI to carry out this test, it is the earliest and best institution in China, has done nearly 10,000 cases, the landlord can search on the Internet, you can rest assured to do their testing, I hope to help you.

Don't worry too much. A high AFP value means that the risk of open neural tube defects is higher, which should be 1 200, that is, that's all. The so-called open neural tube, in which the brain or spine does not close, causes the fetus's AFP to run out.

In severe cases, ultrasound can be seen (confirmatory). Amniotic fluid can be taken to check AFP again, and by the way, you can also look at the chromosomes, but it does not confirm the diagnosis. In short, the possibility of a problem is still small, stay optimistic.

Down's screening is to test the blood of pregnant women, detect the concentration of alpha-fetal protein, chorionic gonadotropin and free estriol in maternal serum, and combine the age, weight, gestational age and other aspects of the pregnant woman to determine the risk factor of fetal congenital stupidity and neural tube defects. The optimal testing time is generally 15-20 weeks.

At present, the Tang screening test is to test the concentration of alpha-fetal protein (AFP) and human chorionic gonadal hormone (-HCG) in the blood of pregnant women, and combined with the age of pregnant women, the risk of each pregnant woman conceiving a fetus with Down syndrome is precisely calculated by using a slip computer.

The normal value of alpha-fetoprotein should be greater than that, and the lower the test value, the higher the chance of the fetus developing Down syndrome. And the higher the chorionic gonadotropin, the higher the chance of the fetus developing Down syndrome. In addition, the doctor will also input the alpha-fetoprotein value, chorionic gonadotropin value, and the age, weight, and number of weeks of pregnancy of the pregnant woman into the computer, and the computer calculates the risk of the fetus developing Down syndrome, if the test results show that the risk is less than 1 270, it means that the risk is relatively low, and the chance of the fetus developing Down syndrome is less than 1.

However, if the risk is higher than 1 270, it means that the risk of fetal disease is high, and amniocentesis or chorionic villus examination should be further done.

To be clear, the Down screening test can only help determine how likely the fetus is to have Down syndrome, but it cannot determine whether the fetus has Down syndrome. That is to say, when the blood test index is high, the chance of conceiving a "Tang" baby is higher, but it does not mean that there must be a problem with the fetus. On the other hand, even if the test index is normal, there is no guarantee that the fetus will not be sick.

Pregnant women with a lower than normal screening index should have amniocentesis or chorionic villus examination, and if the results of amniocentesis or chorionic villus examination are normal, the possibility of Down syndrome can be 100% ruled out.

Finally, please rest assured to do the examination, generally in the early stage of the detection is high-risk and then do the sheep annihilation hand mask puncture examination of the population, the real problem is less than 10.

Please consult a professional doctor at your local maternal and child health hospital.

A screening result for Down syndrome and neural tube defects that is less than the cut-off value means that both Down syndrome and neural tube defects are at low risk, which is a good outcome.

Pregnant women will undergo a test called "Down syndrome" at 15 to 20 weeks of pregnancy, which is a preliminary screening of high-risk pregnant women who may have neural tube defects (such as anencephaly, spina bifida and other -3 syndrome, sosoma 18-3 syndrome, and sosoma 21-3 syndrome), and the results are divided into high-risk (risk) group and low-risk (risk) group.

Down's screening is generally based on the detection results of maternal serum AFP, chorionic gonadotropin (-HCG) concentration, free estriol, combined with maternal age, weight, maternal history and gestational age, to calculate the risk factor of the corresponding disease, and the result is a risk value, such as 1:2000, that is, there is a 1 in 2000 probability of developing the disease. Depending on the software system used, the parameters entered into the analysis vary slightly, and some software also involve the fetal nuchal glial thickness in the calculation, so the reference risk factor is different for each unit.

However, it should be noted that no matter what the result is, it is only a screening result, and there is a certain error in both the high-risk and low-risk groups, i.e., false negatives and false positives. A false positive is when the fetus is normal, and a false negative is a normal report and the fetus is sick. Whether to do amniocentesis or not should be analyzed on a case-by-case basis.

In principle, after excluding interfering factors (generally more common is gestational error), it is recommended to confirm the diagnosis, that is, chromosomal analysis of amniotic fluid fetal cells. If the risk is low, continue with pregnancy testing.

Gestational error is mainly for some pregnant women with irregular menstrual cycles or long cycles (more than 37 days), and the analysis is carried out after correcting the gestational week to eliminate the misjudgment caused by gestational week error.

Down syndrome (down's

syndrome, DS) is the most common chromosomal disease, the incidence is live infants, its main characteristics are mental retardation, congenital multiple malformations, growth and development retardation, so far there is no effective means. The birth of the child brings a great burden to the family and society, if it is diagnosed before childbirth, it can be exempted from the burden of the family and society, in foreign countries, more than 35 years old pregnant women are routinely done amniocentesis, although the puncture has a little risk, such as: causing infection, bleeding, miscarriage, etc., but the incidence is very low, weighing the pros and cons, high-risk expectant mothers should still do amniocentesis to be diagnosed.

The result of your examination is:

If the risk of Down syndrome is low, the pregnancy examination will continue, and amniocentesis is not recommended. May your baby be healthy and healthy!