What s going on with gout? What s going on with gout

Gout is a common and complex type of arthritis that can occur at all ages, with men being more common than women. People with gout often have sudden onset of joint pain at night, with severe pain, edema, redness, and inflammation in the joints, which slowly lessen until they disappear, lasting for a few days or weeks. When pain strikes, patients wake up in the middle of the night in deep sleep, and some patients describe the pain as similar to a fire on their big toe.

The most common joint is the big toe (medical term: first metatarsal), but it is not limited to this joint, but also in the joints of the hand, knees, elbows, etc. (see atlas). Eventually, the affected joints become red, swollen, inflamed, and the tissues become softer, with limited movement and ultimately daily life.

These symptoms can recur, so if you have intense, sudden pain in your joints, you should see a doctor for symptom management and prevention.

Hello, gout is a metabolic syndrome of uric acid metabolism disorder, which is mainly manifested by symptoms such as increased blood uric acid and joint pain. The pain of gout limb is because the uric acid in the body is too high, which will form sodium salt crystals in the joints, which will cause the reflux of tissue cell fluid to be blocked, thus causing pain.

If you already have gout symptoms, the Chinese medicine doctor of the house bureau recommends that you go to a regular hospital for examination as soon as possible, and you must not delay it. Gout is a metabolic chronic disease, and if there is no targeted ** after the first onset, the source judgment will easily imprint the root of the disease after entering the intermittent period of gout, and then cause more serious complications, which must not be taken lightly.

Gout is caused by the increase of uric acid in the blood, and when the saturation concentration in the blood is exceeded, urate may be deposited in the joints or other parts, such as the kidneys. The main reason for the formation of hyperuricemia and gout is that the body's metabolism of purines is disordered, resulting in the synthesis of more uric acid, or because of poor kidney function, uric acid is excreted from the body, resulting in the accumulation of blood uric acid in the body, beyond the normal range, beyond the saturation concentration in the blood, resulting in gout.

Fundamentally speaking, patients with gout have some metabolic disorders in their bodies, and their metabolic capacity is limited, and they cannot fully dissolve the purines they eat, resulting in an increase in blood uric acid. The patient's own physical metabolic ability decreases, and the metabolic function cannot be fundamentally improved. Gout itself is a chronic disease, usually after gout, patients need long-term monitoring and **, especially uric acid-lowering drugs, may need long-term medication.

No disease, no arthritis and no subsequent organ damage are very important endpoints. The most common causes of gout (high blood uric acid) in patients are as follows:

1. Genetic factors: gout is a common metabolic disease, and family members have a certain genetic predisposition;

2. Dietary habits: As a metabolic disease, gout is related to the patient's dietary metabolism and lifestyle habits. Most patients like to eat too much high-purine foods such as animal offal and seafood, and love beer and high-sugar drinks for a few minutes.

3. Other diseases: gout is mostly associated with long-term smoking, taking diuretics and other drugs, or chronic diseases such as diabetes, high blood, obesity and high blood lipids. Gout attacks occur when patients with hyperuricemia are affected by factors such as excessive exercise, trauma, low water intake, or even cold (more commonly after consuming more high-purine foods).

Therefore, whenever there is an acute attack of gout, it is necessary to analyze the specific cause and carry out targeted treatment.

Although gout originates from high uric acid, it does not mean that gout will occur if there is high uric acid, and gout will only occur when uric acid crystals in the blood are deposited in the synovial membrane of the joint and cause synovial inflammation.

Long-term increase in uric acid in the blood is a key cause of gout.

Human uric acid is mainly in 2 aspects. 1) Endogenous uric acid is synthesized by nucleic acids and other purine compounds produced by protein catabolism in human cells. 2) The purines, nucleic acids and nuclear proteins contained in food are digested and absorbed by hunger, and exogenous uric acid is produced after some effects.

In addition, the occurrence of gout is also related to their own conditions, such as obesity, hyperlipidemia, diabetes, hypertension, arteriosclerosis and patients are high-risk groups for gout; Long-term heavy alcohol consumption increases the risk of developing gout.

The reason why you get gout is because urate accumulates in the joints. Now there is a new technology that can make gout dissolve into water and excrete with urine, and Sakura Liang is safe and free from gout. It is urate oxidase, which lowers uric acid from the source, and can be supplemented by drugs or other means, which is very suitable for gout patients who take medicine that does not work, or patients who have a large amount of gout.

Gout is a metabolic disease of orange and oak, due to the improvement of living standards, more and more gout patients, gout used to be called emperor disease, that is, the disease of the rich, but now the general public can get it. The youngest of my patients was a six-year-old child, his parents were surprised, no way, he loves meat too much, so Wuliang gout is a metabolic disease, it is caused by the accumulation of purines. Foods that cause purine accumulation, such as meat, offal, seafood, and beer, are popular with many people.

If the patient has poor purine metabolism and long-term accumulation, the symptoms may be the first in the foot joints, and redness, swelling, heat and pain will appear. Probably the most obvious relief from gout is non-steroidal anti-inflammatory analgesics, some of which work very quickly, in about half an hour. It is recommended to consult a specialist for specific medications.

Gout is actually an increase in blood uric acid in hyperuricemia, which causes urate crystals, which are formed in joints, soft tissues around joints or organs, and then cause crystal arthritis or organ damage after deposition. Generally, gout attacks are more acute, and the symptoms are also obvious, which can cause joint redness, swelling, heat, and pain. If large amounts of crystals form in the kidneys, they may cause acute renal insufficiency, causing oliguric gouty nephropathy.

In addition, after a long-term gout attack, tophi can be formed in local soft tissues, and such cases require active uric acid lowering** to maintain uric acid levels at 300-360 mol l, which can well prevent gout attacks and have a good protective effect on the long-term prognosis of patients.

In the acute phase of gout, rapid pain relief is generally the mainstay, colchicine and various non-steroidal drugs can be selected. Commonly used non-steroidal drugs, such as ibuprofen, celecoxib, loxoprofen, diclofenac sodium, etc. If there are contraindications to the above drugs or adverse drug reactions cannot be tolerated, hormonal drugs can also be used**.

However, hormonal drugs need to be reduced slowly after the disease is controlled, and if the dose is reduced too quickly, it may lead to recurrence of the disease, and hormone drugs should be used with caution in some diabetic patients and patients with severe infections. In addition, in addition to the use of drugs**, it is necessary to strictly control the diet, such as not drinking alcohol, not eating seafood, not eating animal offal and other foods that are too high in purines, etc. During the remission period of gout, the blood uric acid should be continuously reduced, only if the uric acid will be within the normal range, can the gout continue to attack, and uric acid-lowering drugs such as febuxostat, benzbromarone, etc. can be used.

The appropriate drug should be selected according to the type of hyperuric acid in the patient**.

Gout is a crystal-associated arthropathy caused by the deposition of monosodium urate. Gout mainly includes symptoms such as acute onset arthritis, tophi formation, tophi chronic arthritis, urate nephropathy, uric urinary tract stones, joint disability, and renal failure. The main trigger for the onset of gout is the consumption of foods rich in purines.

In fact, gouty arthritis is mainly due to the long-term increase of blood uric acid, which causes uric acid saturation and precipitation to form urate crystals, which are deposited in the joint cavity. In fact, the ** in the attack period of acute gout mainly relies on anti-inflammatory painkillers, and the general improvement period requires continuous uric acid lowering**.

The incidence of gout has increased year by year in recent years, which is due to the change of people's dietary structure, high-purine foods are often on the table, which is one of the main reasons for inducing gout, and the decrease in the excretion of uric acid by the kidneys is another reason.

Some congenital diseases, such as congenital solitary kidney and congenital polycystic kidney disease, can cause abnormalities in the purine metabolism process, which can lead to the accumulation of uric acid in the body. Hyperuricemia can be caused by various kidney diseases and other diseases that cause abnormal kidney function, such as immune system disorders, diabetes, drug-induced kidney disease, high blood pressure, etc.

In general, when people exercise excessively, are exposed to cold, or ingest a large amount of high-purine foods at one time, it is easy for uric acid to accumulate in certain joints, which may cause gout.

Ventilation is associated with hyperlipidemia: ventilation patients have hypertriglyceridemia, and a few have hypercholesterolemia. Ventilation, also known as "hyperuricemia", is a purine metabolism disorder and belongs to a type of arthritis.

Ventilation is a disorder in the metabolism of purine substances in the human body, the synthesis of uric acid increases or decreases, resulting in hyperuricemia, when the blood uric acid concentration is too high, uric acid is deposited in the joints, cartilage and kidneys in the form of sodium salt, causing tissue foreign body inflammatory reaction, that is, ventilation.

Gout is a group of metabolic syndromes caused by long-term elevated blood uric acid, the most common clinical manifestations of gout are gouty arthritis, gouty nephropathy, long-term elevated blood uric acid will also cause adverse effects on the patient's cardiovascular and cerebrovascular and blood glucose. The most common clinical manifestations of gout are intermittent redness, swelling, heat and pain in large joints, mainly in the large joints of the lower limbs, and the most common locations are the big toe, ankle, knee joint, etc. The main characteristics of gouty nephropathy can be manifested as mild proteinuria, hematuria, kidney stones, hydronephrosis, etc., and severe renal insufficiency will occur.

There are many reasons for the appearance of gout, the most common of which is because of the increase of purines, which are deposited in the joints, and the common clinical manifestation is joint pain.

However, in the early stage of gout, the clinical manifestations are often not obvious, this period is mainly due to the increase in the level of uric acid in the blood, most patients do not have any clinical discomfort, and a small number of patients will have joint swelling and pain, but it is not very obvious.

During the acute attack, pain in the joints of the lower limbs and toes will occur, mainly due to the deposition of uric acid. Joint pain may also occur during intermittent periods, but the pain is less severe than before. If a patient with gout develops tophi, i.e. urate crystals are deposited in joints and other areas, it can cause persistent pain and even joint deformities.

For patients with gout, it is necessary to reduce the intake of purine-rich foods in daily life, such as seafood, mutton, etc. You can eat more vitamin-rich fruits and vegetables, such as celery, rape, and so on. In addition, it is not recommended for patients with gout, as studies have shown that alcohol can increase the burden on people with gout.