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The use of two or more drugs in the same animal at the same time or in a short period of time is called a combination drug or a combination of drugs. The aim is to enhance efficacy and reduce adverse effects for different symptoms or comorbidities. After the compatibility of drugs, the drug effect is enhanced, and the synergistic effect is enhanced; After the compatibility of drugs, the effect of the drug is weakened.
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The compatibility relationship of various Chinese medicines can be summarized as follows; There is a one-way person who is a kind of medicine. The opposite is the combination of two drugs with similar efficacy to increase the efficacy of the original drug. Such as ephedra with cinnamon branches.
One drug is the main one and the other is supplemented, and the auxiliary drug can improve the efficacy of the main drug. For example, skullcap with Poria cocos to treat spleen deficiency and edema. The toxicity of one drug is inhibited by another drug, such as Banxia phobia ginger.
Killing each other means that one drug can eliminate the poison of another drug. Such as sheep blood kills hook kiss poison. The one is one drug that destroys the efficacy of another, such as ginseng sulforaphane.
On the contrary, the use of two drugs together can produce violent poison, such as licorice anti-gansui, which has eighteen anti-and nineteen fears.
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Hehe, it's like a chef with spices.
Legend has it that the ancestor of traditional Chinese medicine, Yi Yin, was the prime minister of the Shang Dynasty and a cook. Therefore, Chinese medicine prescriptions are called "soup". It's from the chef.
The two chefs use smoked sauce and vinegar to blend the ingredients, why is the dish made by this chef not as good as the other chef?
Similarly, the two traditional Chinese medicines use those traditional Chinese medicines in the pharmacy, but the effects of the traditional Chinese medicines are different.
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(1) Nineteen fears:
Sulfur is afraid of Pu nitrate, mercury is afraid of arsenic, wolf poison is afraid of Tantra monks, croton is afraid of petunias, cloves are afraid of tulip, Sichuan Wu, grass Wu is afraid of rhino horn, tooth nitrate is afraid of three edges, Guan Gui is afraid of stone fat, ginseng is afraid of five spirit fat.
2) Eighteen anti:
licorice anti-gansui, euphorbia, seaweed, coriander; Aconitum anti-fritillary, melon wilt, banxia, white sage, white and; Quinoa anti-ginseng, sand ginseng, salvia, scutellaria, asarium, peony.
There are slight discrepancies in the subsequent "Compendium of Materia Medica" and "Pharmacology" and other books, but they are not as widely recognized and disseminated as the Eighteen Anti and Nineteen Fearful Songs.
Shennong's Materia Medica: Preface points out that "do not use the opposite and the opposite", "if it is poisonous, it is appropriate to make it, you can use those who fear each other and kill each other, and do not use it". Since the Song Dynasty, the relationship of "mutual fear" has also been listed as a taboo, which is confused with "mutual evil". Therefore, the concept of "nineteen fears" is not the same as the meaning of "mutual fear" of one of the "seven feelings" discussed in the section "compatibility".
Some of the "Nineteen Fears" and "Eighteen Anti" medicines are somewhat different from the actual application, and the doctors of the past dynasties have also discussed them, citing ancient prescriptions as evidence to prove that some drugs can still be used together. For example, the croton in the induction pill is used with morning glory; Gansui Banxia soup is juxtaposed with licorice and Gansui; Disperse swelling and ulcer soup, seaweed and jade pot soup, etc., are combined with licorice and seaweed; The Ten Spices Rejuvenation Pill is a combination of cloves and tulips; The big active Dan aconitum is used with rhino horn and so on. Some experimental studies have preliminarily shown that when the two drugs are combined, the toxicity mainly depends on the proportion of licorice, and if the dose of licorice is equal or greater than that of Gansui, the toxicity is greater; For example, fritillary and banxia were compatible with Aconitum respectively, and no obvious enhancement of toxicity was observed.
The combination of asarum and veratrol can lead to poisoning and death in experimental animals. Since the study of the "19 fears" and the "18 antis" still needs to be further carried out in terms of experiments and observations, and their mechanisms should be studied, a cautious attitude should be adopted at present. Generally speaking, for some of these drugs, if there is no sufficient basis and application experience, it is still necessary to avoid blind cooperation.
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It is a combination of three parts of medicine, a combination of Chinese herbal medicines, according to the condition, medicinal properties and requirements to be correctly configured, the allocation of contraindications, drug contraindications, dosage and dosage and other main contents.
Compatibility: 1 Mutual Requirements.
That is, the combination of drugs with similar performance and efficacy can enhance their original efficacy. For example, the combination of gypsum and Zhimu can significantly enhance the effect of clearing heat and disliking fire; The combination of rhubarb and miscanthus can significantly enhance the effect of attacking diarrheal heat.
2 Phase. That is, there is a certain common drug in terms of performance and efficacy, and one drug is the main drug, and the other drug is supplemented, which can improve the efficacy of the main drug. For example, when the astragalus membranaceus that replenishes qi and water and the poria cocos that improves water and strengthens the spleen are combined, Poria cocos can improve the best effect of astragalus to replenish qi and water; When the skullcap that clears heat and fires is combined with the rhubarb that kills the heat, the rhubarb can improve the effect of the skullcap on clearing heat and dispelling fire.
3 Fear of each other. That is, the toxic reaction of one drug or *** can be mitigated or eliminated by another drug. For example, the toxic properties of Shengbanxia and Shengnanxing are reduced and eliminated by ginger, so it is said that Shengbanxia and Shengnanxing are afraid of ginger.
4 Kill each other. That is, one drug can reduce or eliminate the toxicity of another drug. For example, ginger can reduce or eliminate the toxicity of raw Banxia and Shengnanxing, so it is said that ginger kills the poison of Shengbanxia and Shengnanxing. It can be seen from this that fear and kill each other are actually two terms of the same compatibility relationship, which are in terms of mutual treatment between drugs.
5 Evil. That is, when two drugs are combined, one drug acts with the other drug and the original efficacy is reduced, or even the drug is lost. For example, ginseng is evil sulforaphane seeds, because sulforaphane seeds can weaken the qi-replenishing effect of ginseng.
6 On the contrary. That is, the combination of two drugs can produce toxic reactions or ***. For example, some drugs in the "Eighteen Anti" and "Nineteen Fears" (see "Drug Contraindications").
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To put it simply, it is to set a few flavors of Chinese medicine, how much, and match them into a team, ** relative diseases.
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Generally, eighteen anti-nineteen fears are used.
The specific content of the "eighteen antis" is: licorice anti-gansui, euphorbia, seaweed, coriander; Aconitum anti-fritillary, melon, banxia, baijiu, baiji; Quinoa anti-ginseng, sand ginseng, salvia, succulent, sophora, asaroxin, peony. The specific content of the "Nineteen Fears" is:
Sulfur phobia, mercury phobia arsenic, wolf venom phobia tantric monk, croton phobia petunia, clove phobia tulip, Sichuan Wu, grass Wu phobia rhino horn, tooth nitrate phobia triangular grease, Guan Gui phobia phobia red stone grease, ginseng phobia five spirit fat.
The above contraindications can be used as a reference for medication, but this is not absolute. In the application of ancient and modern formulas, there are also some anti-fear applications, such as the combination of the five spirit fats can tonify the spleen and stomach and relieve pain, which must be applied under the guidance of experienced clinicians.
There is also a song recipe. Materia Medica clearly states eighteen antis.
Half of the shellfish attacked Ukraine.
Algae halberd then coriander war grass.
Ginseng and peony rebel veratrum.
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This can be written as a **too much, and the big aspects are: 1Compatibility taboo 2Contraindications to the disease.
3.Contraindications for special populations (old, weak, pregnant, childbirth, etc.).
4.Contraindications to taking medications.
5.Toxic drugs are contraindicated.
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