What are the early manifestations of muscular dystrophy?

Muscular dystrophy is an umbrella term for a group of inherited skeletal muscle disorders that result in protein defects or dysfunction due to genetic variations in the genes encoding muscle cell-associated proteins, resulting in disruption of muscle cell integrity. The early symptoms are mostly different from person to person, the common manifestations are abnormal walking posture, slow running, easy fatigue, a little effort to go upstairs, frequent falling, etc., and even some patients do not have any symptoms in the early stage, only the liver enzymes are found to be elevated during the physical examination, and the creatine kinase is elevated on further examination, and muscle diseases are considered only when the disease is diagnosed, which is mainly diagnosed by muscle pathology and genetic examination.

Muscular dystrophy is a group of inherited degenerative diseases that originate in muscle tissue. It occurs more often in children and adolescents and is predominantly in males. The disease is invasive in origin, and is usually manifested by progressive muscle atrophy and weakness, and pseudohypertrophy is common.

The cause of muscular dystrophy is believed by most scholars to be a group of inherited muscle degenerative diseases. It is mostly recessive. In addition, there are theories such as cell membrane, autoimmunity, vascular origin, and neuronalism.

In recent years, most scholars believe that this disease is caused by some metabolic defect of hereditary muscle cells, resulting in changes in the structure and function of cell membranes, and due to mutations (deletions or duplications) of this gene, its gene product - dystrophin, cannot be expressed normally on the muscle membrane. Membrane biochemical analysis showed that dystrophin is a rod-shaped protein with a molecular weight of 427 kd, which is located on the cytoplasmic side of the muscle membrane and binds to transmembrane glycoproteins to form a complex and is linked to the cohesin of the extracellular matrix layer. In children with DMD, due to the defective expression of dystrophin on the muscle membrane, the cell membrane structure is abnormal, a large amount of calcium ions are influxed, and the muscle is progressively necrosis.

Therefore, the gene defect of DMD makes the production of submembrane protein-dystrophin disorder, which is the cause of abnormal cell membrane function and the main mechanism of disease.

Muscular dystrophy is when the baby's limbs and body slowly shrink. In this case, it is necessary for parents to pay more attention to strengthening nutrition and supplementing calcium tablets for their children, drink milk, massage their children more, and accompany their children to exercise more.

It is mainly the progressive weakness and atrophy of the muscle groups in some symmetrical parts, walking and swaying, easy falling, difficulty going upstairs, and difficulty squatting.

1. Weakness of the body.

The initial manifestations of muscular dystrophy are not obvious, but if you look closely, you can see that muscular dystrophy patients are very different from normal people. For example, in the absence of any factors, patients are prone to physical fatigue, weakness and other symptoms, and this phenomenon may also be cyclical, often occurring at a specific time.

2. Atrophy of muscles or bones and joints.

Muscular dystrophy patients are mainly manifested by physical wasting in the early stage, and as the patient ages, the condition will continue to worsen, which will then lead to the contraction of muscle and bone and joint tissues, which is mainly manifested in the decline of elasticity, joint swelling or stiffness, and poor activity. Symptoms that are not severe in the early stages usually do not interfere with normal activities, but as atrophy symptoms worsen, patients may experience reduced mobility and even inability to eat independently.

3. Difficulty in moving.

Muscular dystrophy causes damage to every muscle tissue in the body and affects the patient's ability to move autonomously. In the early stages of the disease, patients may present with symptoms such as difficulty climbing stairs, easy falls, and shaky walking. As the disease worsens, the lesions will engulf the patient's entire nerve and muscle function, and these symptoms will become more severe, and it is difficult to even raise the hand and eat basically.

1. Weakness of the body.

Weakness is difficult to detect in the early stages of muscular dystrophy and can only be felt if you look closely. Usually, symptoms such as general malaise, physical tiredness, and mental abnormalities are also present. In addition, body weakness is cyclical and usually occurs at a fixed point in time, but the point in time at which it occurs is not fixed for each person.

2. Muscle atrophy.

Muscle wasting is the most common symptom of muscular dystrophy and can get worse as the disease progresses. At the same time, the patient will be accompanied by emaciation. In addition, joint pain, deterioration of mobility and other conditions may occur, and in severe cases, it may even reach the point where it is impossible to eat.

3. Difficulty in mobility.

Long-term muscular dystrophy can adversely affect the muscles, reduce the ability to move carefully, and cause symptoms of immobility. This symptom is mainly manifested as walking shaky, easy to fall, etc., and in severe cases, loss of self-care ability may occur.

Muscular dystrophy is a common neuromuscular disorder characterized by damage and atrophy of skeletal muscle. Antecedents may include the following symptoms:

Decreased exercise capacity: People gradually feel that their ability to exercise begins to decline, and activities such as climbing stairs and lifting weights become more difficult.

Muscle weakness: Patients may experience symptoms of muscle weakness, manifested as weakness in the legs when walking, weakness in the arms when lifting objects, etc.

Fatigue: People may feel fatigued, and light physical activity can make them feel very tired.

Weight loss: Patients may experience weight loss due to muscle atrophy.

Body stiffness: After muscle atrophy and dust shrinking, patients may feel that their body becomes stiff and they are not as flexible as before.

Reduced facial expressions: Patients may feel a decrease in facial expressions, such as eyes no longer blinking, mouth no longer active, etc.

It is important to note that these symptoms do not always occur at the same time, and may also be a manifestation of other diseases. If you suspect that you have muscular dystrophy, you should go to the hospital as soon as possible for a professional examination and**.

Fatigue and poor mental state, etc.

Muscular dystrophy is particularly common, the disease has troubled more friends, is extremely unfavorable to physical health, the symptoms are obvious during the onset of the disease, and will trouble the daily life of the patient's friends, the patient has the symptoms of closed eyes and weak blowing, resulting in special distress for the patient. Patients should be thoroughly aware of the disease and understand the symptoms of the disease. So what are the symptoms of muscular dystrophy?

Muscular dystrophy is very common and harmful, and more causes induce the appearance of the disease, resulting in the patient's physical health being endangered, accompanied by the symptoms of weakness and general fatigue, reminding the patient to pay attention to muscular dystrophy and understand the symptoms of the disease.

In recent years, the incidence of muscular dystrophy is particularly high, a lot of friends have been troubled by the disease, harming the health of the patient, and will induce the symptoms of physical discomfort, we should understand the disease thoroughly, and to grasp the symptoms of the disease, generally speaking, patients with mild symptoms can not have any symptoms, and will only be found during the occasional examination, in the early childhood or adolescence often insidiously onset, a few years after the onset of the disease.

Patients are prone to atrophy and weakness of the shoulder girdle muscles, neck muscles and brachial muscles, severe atrophy of the shoulder girdle and humeral muscles, and the acromion on both sides produces carina, resulting in abnormal scapular parts of the patient, if it is a limb girdle type patient, it leads to the symptoms of weakness and atrophy of the patient's pelvic girdle muscles, and with the development of the disease, it is easy to involve the patient's shoulder girdle.

Traditional Chinese medicine ** muscular dystrophy effect is quite good. One of the major advantages of traditional Chinese medicine is that the dialectical theory of traditional Chinese medicine is fully applied to the entire diagnosis and treatment process, from the overall dialectic to the individual dialectic, and each patient is analyzed as an independent system, that is to say, the syndrome differentiation theory is applied to the diagnosis and treatment process of each patient.

Patients with muscular dystrophy may show the following symptoms: 1. Symptoms of fatigue, which may be caused by fatigue without any precipitating factors at the time of initial consultation, and fatigue may be cyclical, that is, muscle weakness will occur at a specific time every day. As fatigue worsens, it is not even possible to walk upright.

2. In the case of muscle atrophy, you can do normal activities and diet, while the muscles will have progressive atrophy and slender limbs. 3. Muscle tone is significantly reduced, and muscle tone refers to the tension maintained by muscles when they are inactive. If the patient's joint is passively stretched, the muscles will reflexively produce tension, which in turn will maintain the stability of the joint and prevent the joint from overmoving.

Patients with this type of disease may feel a decrease in muscle tone and weakness all over their joints when they stretch their joints.

Muscular dystrophy symptoms.

1. Facicoshoulder-humeral muscular dystrophy: both men and women, onset in adolescence, first of all, facial muscle weakness, often asymmetrical, unable to show teeth, protruding lips. With the eyes closed and frowning, the orbicularis oculi muscle may have pseudohypertrophy, resulting in hypertrophy of the lips and protruding lips, and some shoulder and humeral muscles are affected first, so that the arms cannot be raised to form a hanging shoulder, and the muscles of the upper arm are atrophied, but the muscles of the forearm and hand are not violated.

The course of the disease progresses very slowly, often with abruptness or remission.

Muscular dystrophy symptoms.

2. Limb girdle muscular dystrophy: seen in both sexes, starting in children or young adults, first affecting the pelvic girdle muscles and psoas major muscles, difficulty walking, unable to climb the stairs, swaying gait, often falling, and some only involve the quadriceps muscle. The course of the disease progresses very slowly.

Muscular dystrophy symptoms.

3. Pseudohypertrophy: X-linked recessive inheritance, which is the most common type, and can be divided into Duchenne type and Becker according to clinical manifestations.

1. Duchenne malnutrition: also known as severe pseudohypertrophic malnutrition, almost only seen in boys, if the mother is a gene carrier, 50% of male offspring have the disease, often onset at the age of 2-8 years, the initial feeling of walking is clumsy, easy to fall, can not run and climb the stairs, the spinal cord is lordosis when standing, the abdomen is protruding, the feet are aside, the walk is slow and swaying, showing a special "duck step" gait, when it is very difficult to walk from the back, you must first turn over and lie on your stomach, and then climb the knees with both hands, and gradually support yourself to stand up ( Gower's sign). It can also be seen in the proximal limb muscles, quadriceps, and brachial muscles.

2. Becker type: also known as benign pseudohypertrophic muscular dystrophy, often onset after the age of 10, the first symptom is the weakness of the pelvic girdle and femoral muscles, the progress is slow, the course of the disease is long, and the symptoms appear 25 years or more before they can not walk, most of them are still not paralyzed at the age of 30-40, and the prognosis is better.

Muscular dystrophy symptoms.

Fourth, quadriceps type, distal type, progressive extraocular muscle paralysis type, ophthalmo-pharyngeal muscle type, etc., are very rare.

Muscular dystrophy is a prominent symptom of pelvic girdle muscle weakness, which is manifested by slow walking, tiptoe landing, and easy falling. Difficulty ascending stairs, squatting, and standing due to weakness of the iliopsoas and quadriceps muscles. Weakness of the back extensor muscles, which makes the lumbar spine excessive lordosis when standing, and weakness of the gluteus medius, causing the pelvis to swing up and down to the sides when walking, in a typical duck step.

The scapular-girdle muscles and upper arm muscles are often affected at the same time, but symptoms are milder. The two shoulder blades, which are erected on the back in a wing-like shape, are called pterygoid scapulae, and 90% of patients have muscle pseudohypertrophy, which is tough to the touch, most notably the gastrocnemius muscle. Most patients have myocardial damage, such as arrhythmias.

Patients generally develop symptoms in early childhood, which are characterized by abnormal muscle function due to mutations in dystrophin expression, such as clumsiness in walking, easy falling, difficulty climbing and descending stairs, and abnormal creatine enzymes.