Definition and characteristics of combinatorial chemistry and what is combinatorial chemistry

What is combinatorial chemistry is as follows:

Combinatorial Discussion is a science that combines chemical synthesis, combinatorial theory, computer-aided design and manipulator, and in a short period of time, different building blocks are cleverly conceived, and the system is repeatedly connected according to the combination principle, so as to generate a large number of molecular diversity groups and form a compound library, and then, using the combination principle, the library components are screened and optimized by ingenious means to obtain possible compound structures with target properties. <>

Combinatorial chemistry is significantly different from conventional synthesis. Traditional synthesis methods synthesize only one compound at a time; Combinatorial synthesis uses n units of one building block to perform a one-step reaction with n units of another building block at the same time to obtain n compounds; If the m-step reaction is performed, (nn)m compounds are obtained.

It has been calculated that it takes a chemist a year to complete the work of a combined chemical method in 2 to 6 weeks, and ten chemists to complete it with a traditional synthetic method. Therefore, combinatorial chemistry has greatly improved the synthesis and screening efficiency of new compounds, reduced the consumption of time and money, and has become a hot spot in the research of penitential chemistry at the end of the 20th century.

Combinatorial Chemistry Synthesis Technology and Its Impact on Traditional Pharmaceutical Synthetic Chemistry Combinatorial Chemistry Synthesis Technology.

Combinatorial chemical synthesis includes three steps: preparation of compound libraries, detection of library components, and screening of target compounds. The preparation of compound libraries includes two technologies: solid-phase synthesis and liquid-phase synthesis, and the preparation of general modules is mainly liquid-phase synthesis, while the establishment of libraries is mainly solid-phase synthesis.

Coordination compounds are formed by the combination of a central atom or ion and a molecule or ion called a ligand around it, complete or partially trapped by a coordination bond. A compound is a pure substance consisting of two or more elements.

In simple compounds, atoms are only connected by covalent bonds or ionic bonds, while complexes are cultured with central atoms and ligands linked together by coordination bonds, which are different from general covalent bonds and ionic bonds.

The oxalic acid in the figure below is a simple compound, while [Fe(C2O4)3]3- is a complex, and the three oxalate ions are linked to iron ions through coordination bonds to form the [Fe(C2O4)3]3- complex.

Usually due to the fact that the complex has a variety of functional groups and a special geometrical structure, it has optoelectromagnetic properties that simple compounds do not have.

<> "Combinatorial chemistry is a chemical discipline that studies the combination of two or more molecules through chemical reactions to form complexes. It focuses on the construction, separation, purification, characterization and application of complexes in the fields of chemistry and biochemistry. The main features of combinatorial chemistry include:

1.Focus on intermolecular interactions: Combinatorial chemistry focuses on intermolecular interactions, and studies how to chemically control the binding and reaction between molecules to form new complexes.

2.Constructing a diverse molecular library: Combinatorial chemistry technology has the advantage of rapidly constructing a large-scale diverse molecular library, which can efficiently screen out compounds with specific biological activities, which is of great significance for drug discovery and research.

3.Research on multi-component reactions: Combinatorial chemistry focuses on the study of the chemical mechanism and reaction conditions of multi-component reactions, and can control the products and selectivity of reactions by changing reaction conditions.

4.Emphasis on high-throughput screening: Combinatorial chemistry techniques have the advantage of high-throughput screening, enabling efficient screening of large numbers of compounds and complexes to discover new bioactive substances or compounds.

5.Involving multiple disciplines: Combinatorial chemistry technology involves many disciplines such as organic synthetic chemistry, biochemistry, medicinal chemistry, and materials chemistry, and has a wide range of application value and research prospects.

<> "Combinatorial chemistry is a chemical research method that mainly studies how to synthesize new chemical substances and explores the regularity and characteristics of different elements and molecular combinations. Its features include:1

The main task of combinatorial chemistry for the synthesis of new compounds is to synthesize new compounds. Through different combinations and conditions, new, useful, or special compounds can be prepared. 2.

In the process of exploring regular combinatorial chemistry, the reaction laws are explored by adjusting the reaction conditions and changing the proportion of reactants. This provides insight into the relationship between molecular structure and properties, providing guidance for the synthesis of more desirable compounds. 3.

Experimental combinatorial chemistry emphasizes laboratory experiments, which require the characterization of newly synthesized compounds through a large number of experimental data, and the determination of structure and properties. The experimental results can be used to validate theoretical hypotheses and guide further research. 4.

Interdisciplinary combined chemistry involves a variety of disciplines, including organic chemistry, inorganic chemistry, physical chemistry, etc. and cross-collaboration with other fields, such as applications in medicinal chemistry, materials science, chemical biology, etc.

The advent of combinatorial chemistry has greatly accelerated the synthesis and screening of compounds, and some people have made such statistics: 1 chemist using a combination of chemical methods for 2 6 weeks of work, it takes 10 chemists to use traditional chemical methods to complete a year. The emergence of combinatorial chemistry is a revolution in pharmaceutical synthetic chemistry, and it is one of the most significant advances in the field of drugs in recent years.

Before the advent of combinatorial chemistry, the development of new materials had been slowed down by the trial-and-error method, which was very inefficient. Since the 90s of the 20th century, combinatorial chemistry has made breakthroughs in the field of material synthesis.

Combinatorial chemistry is a new discipline that has just emerged in the past decade. After more than ten years of development, especially in the past six or seven years, combinatorial chemistry has penetrated into many fields of pharmaceutical, organic, materials, analytical and other fields of chemistry, and with the improvement of automation level, combinatorial chemistry has become one of the most active fields in the field of chemistry.