Which blood type matches can easily cause hemolysis in children

The complete set of hemolysis generally refers to understanding the fragility of white blood cells and red blood cells, and understanding the overall situation of red blood cells, and whether red blood cells are relatively fragile and easy to lead to hemolysis. Look for hemolysis **, which is helpful to find a history and give to improve the situation. If you are also anemic, you should give a targeted ** after finding it, such as iron deficiency anemia that needs to be improved by iron supplementation.

Hemolytic transfusion reactions.

Hemolytic transfusion reaction is a series of reactions caused by the destruction of red blood cells after blood transfusion, and there are acute hemolytic transfusion reactions and delayed hemolytic transfusion reactions.

1. Reasons (1) Immune hemolytic reaction: 1. ABO blood group incompatibility: the antibody is IgM antibody, which is a natural complete antibody, mainly intravascular hemolysis.

2. Rh blood group incompatibility: the antibody is IgG antibody, which is an immune incomplete antibody, mainly extravascular hemolysis. 3. Hemolysis caused by incompatibility of blood group systems in other blood group systems:

Such as MNSS, Lewis, Kell, Di, etc., hemolysis occurs intravascular or extravascular. 4. Blood type incompatibility among blood donors: It is seen in a large number of blood transfusions or transfusions of blood from multiple donors in a short period of time.

2) Non-immune hemolytic reactions: such reactions are less common and include hypotonic fluid infusion; Freezing or overheating or mechanical manipulation to destroy red blood cells; mixing of certain drugs; The person who donated or received blood has a defect in red blood cells (such as certain red blood cell defect disorders).

2. Symptoms and signs.

1) Most of these reactions occur in the early stage of the blood transfusion process, after the infusion of tens of milliliters, manifested as chills, facial flushing, dyspnea, hypotension, wound bleeding, hemoglobinuria, oligouria, urinary continence, and even the development of renal failure and uremia (often 1-2 weeks after the reaction).

2) The patient may suddenly go into shock, and extensive bleeding and coagulation disorders may occur, which can cause DIC in one step.

3) Delayed hemolytic reaction: mainly extravascular hemolysis. It is common in rh incompatibility and occasionally in other blood groups.

In multiparous women or those with a history of blood transfusion, fever, anemia, jaundice, mild symptoms, reticulocytosis, spherocytosis, decreased nodal globulin, hepatosplenomegaly, and hemoglobinuria are rare in the days or weeks after transfusion.

The same blood type transfusion will not occur hemolytic reaction, different blood type transfusion has hemolytic reaction, AB universal blood transfusion, O universal blood recipient Human red blood cell surface contains some antigens called agglutinin, generally more important and more well-known is a agglutina and B agglutinin, generally according to the type of agglutina blood group is divided into A, B, O and AB types, and anti-agglutinin is called lectin, type A blood always has anti-agglutinin B antibody, called anti-B lectin, type B blood has anti-A lectin, People with type AB blood do not have both lectins, while people with type O blood have both lectins.

General blood group detection is the use of the above principle, the use of cell antigen or serum and the blood of the test subject, the detection of human blood types A, B, O and AB four blood types, but also due to the relationship between the above lectins, type AB people are all-powerful blood recipients, and type O people are all-round blood donors.

The blood group system includes four blood types.

The blood group system includes four blood types. It may also be known that children born to parents of two types can only have the same blood type; In addition to the blood type, the blood type of the child born to the parents of the two types may be type, but it may be type or type; However, when the blood type of the parents is type and type respectively, the blood type of the child born to them may be type, type, type or type. It turns out that the so-called blood type actually refers to three blood group substances, type, and type, which are also three genetic factors.

It has been found that blood group substances are only found in type and blood group, and blood type substances are only found in type and blood group, while blood type substances are only present in type and are also found in type, type and type. Therefore, when the universal transfuse type of blood is transfused to the type, type, and type, because the type, type, and type have the same blood type substance as the type, the recipient will have a hemolytic reaction in the future. On the contrary, due to the type and type of blood group substance, once the type of blood is received, the type or type of blood will produce a hemolytic reaction.

Similarly, type and type can both transfuse each other and accept type of blood, otherwise there will also be a hemolytic reaction.

Based on the fact that the same blood type has the same blood type substance, that is, it has the same blood group genetic factors, we can realize that the so-called blood type can actually be called a type, and the type is actually a type.

Children with blood types A and O are more likely to have hemolytic babies.

It will have a serious impact, which will affect the child's vision, may lead to anemia in the child, may lead to the child's generalized edema, and may lead to the child's death from heart failure.

It will have a great impact on the child, because it is likely to affect the child's development, and there may be congenital diseases, and it may affect the development of intelligence, and in severe cases, it is likely to threaten life.

It can cause the baby to have weakness in the limbs, hotheadedness, dizziness, loss of appetite and lack of sleep.

It can cause serious effects and may cause edema in your child, kidney disease, and severe cardiovascular disease.

ABO hemolysis is caused by mother-to-child blood group incompatibility. There are many undesirable phenomena that occur in hemolytic babies. Why does a parent's blood type dissolve blood? What blood type is a hemolytic parent? Then let's find out through blood group analysis! Let's take a look!

What blood type of the parents will cause hemolysis.

In the ABO system, if the mother has blood type O and the father has non-O blood type, i.e. blood type A, B or AB blood type, then the baby has the possibility of ABO hemolysis. However, when the mother has blood type A, B, or AB, the fetal buried baby generally does not have ABO hemolysis. In other words, only if the mother has blood type O, the fetus may have ABO hemolysis.

In this case, when the mother has blood type O and the fetus has blood type A, the fetus has a greater chance of getting sick because antigen A is more antigenic than antigen B.

Hemolytic parental fluid spike blood type.

ABO incompatible hemolytic disease usually occurs when the mother's blood group is O and the paternal blood group is A, B, or AB.

ABO hemolytic features.

The main signs and symptoms of the disease are edema, jaundice, anemia, and hepatosplenomegaly. The severity of symptoms depends on the number of antibodies, neonatal maturity, and compensatory hematopoietic capacity.

1.Jaundice is the main symptom of ABO hemolytic disease, which mostly occurs in the first 2-3 days of life. About 1 in 4 developed jaundice in the first day of life, and about 1 in 4 developed severe jaundice.

Jaundice peaks after 4-5 days, mainly moderate, with a few severe sales. Severe jaundice may present with symptoms of kernicterus, such as refusal to eat, poor response, screaming, retroflexion of the angular arch, and convulsions.

Patients with hemolytic anemia have varying degrees of anemia, but the degree is generally mild. Severe anemia accounts for only about 5%. In some mild cases of ABO hemolytic disease, early symptoms may not be severe, but later anemia occurs at 2-6 weeks after birth, or at 8-12 weeks after birth when anemia is particularly severe.

This is because the persistence of blood group antibodies shortens the lifespan of red blood cells, leading to chronic hemolysis.

According to reports, the red blood cell life span of such children is only about 35 days, and the daily decrease in hemoglobin is about 4 times that of normal children in the same period, and the degree of red blood cell destruction increases. At this time, the physiological function of bone marrow hematopoiesis is low, and it cannot be effectively compensated, resulting in anemia in the later stage of the neonate.

3.Shortness of breath and rapid heartbeat.

4.Hepatosplenomegaly, compensatory hyperplasia of bone marrow and extramedullary hematopoietic tissues, causing varying degrees of hepatosplenomegaly. Scattered extramedullary hematopoietic foci can be seen under the microscope, distributed in liver, spleen, lung, pancreas, kidney and other tissues.