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Acute leukemia often progresses rapidly and is characterized by the replacement of normal bone marrow by a primitive cell clone formed by the malignant transformation of hematopoietic stem cells.
Acute leukemia consists of acute lymphoblastic leukemia (ALL) and acute non-lymphocytic leukemia (ANLL, AML).
Leukemia cells accumulate within the bone marrow to replace normal hematopoietic cells and spread to the liver, spleen, lymph nodes, central nervous system, kidneys, and gonads. Because these cells are carried by the blood, they can infiltrate any organ or site. Acute lymphoblastic leukemia often invades the central nervous system; Acute monocytic leukemia often affects the gingiva; Acute myeloid leukemia can cause localized damage (granulocytic sarcoma or green tumor) at any site
Leukemic infiltrates are characterized by patches of undifferentiated round cells that generally cause minimal disruption to organ function except for the central nervous system and bone marrow. Meningeal infiltration leads to increased intracranial pressure; Bone marrow infiltration replaces normal hematopoiesis and causes anemia, thrombocytopenia, and granulocytopenia.
Signs and symptoms.
Symptoms of acute leukemia are often nonspecific (eg, fatigue, fever, malaise, weight loss) that reflect normal hematopoietic failure. Although neutropenia often leads to severe bacterial infections; However, the cause of leukemia fever is often difficult to identify. Bleeding manifests as ecchymosis and mucosal bleeding (e.g., nosebleeds) or menstrual irregularities.
Hematuria and gastrointestinal bleeding are uncommon. Symptoms such as headache, vomiting, and irritability are often absent in the early stages of central nervous system involvement. Bone and joint pain may sometimes be complained, particularly in acute lymphoblastic leukemia.
Laboratory tests and diagnosis.
Anemia and thrombocytopenia are extremely common (75% to 90%)The number of white blood cells may be decreased, normal, or increased. If the white blood cell count is not significantly reduced, leukemic blasts will inevitably be seen in the blood film.
Although diagnosis is usually based on blood radiographs, bone marrow examination is always done to confirm the diagnosis. Sometimes too few cells are needed to remove bone marrow, and a bone marrow biopsy is done. Aplastic anemia, infectious mononucleosis, and vitamin B12, folate deficiency and other disorders should be taken into account in the differential diagnosis of severe pancytopenia.
Histochemical, genetic, immunophenotyping, and molecular biology methods can be used to distinguish blasts from acute lymphoblastic leukemia and acute non-lymphocytic leukemia. In addition to generally stained blood slides, terminal transferase, bone marrow peroxidase staining, Sudan black B staining, and histochemical staining for specific and nonspecific lipases are often helpful.
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The main causes of acute leukemia infection are:"Lack of mature granulocytes, followed by decreased immunity in the body. Stomatitis, gingivitis, angina, pulmonary infections, and perianal abscess are common"
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It's hard to say in this way, depending on the individual's immunity.
Acute leukemia is generally more susceptible to infection, especially during chemotherapy, and various pathogens may cause serious infection to it, so during re-chemotherapy, it can be prevented with the practice of [Han Qifeng's mental journey]**.
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Answer] :d patients with acute leukemia have leukemia cells (malignant cells) infiltrating the bone marrow, resulting in impaired normal hematopoietic function, resulting in a decrease in the production of normal white blood cells, red blood cells, and platelets, and a decrease in the production of normal mature neutrophils, which is the most important cause of secondary infection in Chongjing patients.
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Answer]: C Acute Baiqi annihilation blood disease is caused by the production of too many naïve cells, resulting in a decrease in mature granulocytes, and the body's ability to talk about side-rush resistance and infection is reduced, resulting in recurrent infection.
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Answer]: C infection can occur in various parts, with stomatitis being the most common, gingivitis and angina are also common infections, and lung infection, perianal inflammation, and paraanal abscess are also common.
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The main causes of infection in children with acute leukemia are ().
a.Gastrointestinal function is disordered and nutrient deficiencies.
b.Surgery or noisy catheters have caused ** breakage.
c.Affected by disease or chemotherapy, white blood cells and neutrophils are reduced.
d.Lack of effective antibiotics.
e.Immune dysfunction.
Correct answer: c
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Answer]: B More than half of the patients have bleeding, the degree of mild Huai is different, the location can be all over the body, the surface spike is now petechiae, ecchymosis, nosebleeds, gingival bleeding and menorrhagia, fundus bleeding, etc., bleeding is mainly platelet significantly reduced, platelet dysfunction, coagulation factor reduction, leukemia cell infiltration, bacterial toxins, etc. can damage blood vessels and cause bleeding. Acute promyelocytic leukemia is often accompanied by disseminated intravascular coagulation (DIC) leading to widespread bleeding throughout the body.
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Answer]: A The most common location of infection, such as stomatitis, gingivitis, and pharyngina is usually seen with the hands closed, and ulcers or necrosis can occur, and there can also be pneumonia, enteritis, pyelonephritis, perianal abscess, and severe sepsis or bacteremia.
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Answer]: A The most common pathogenic bacteria for leukemia infection are gram-negative bacilli, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, aerogenic bacillus, etc. Note:
Although routine oral infections are more common with anaerobic bacteria, oral infections with acute leukemia are more common with gram-negative bacilli. Bad spike.
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Answer]: Cblasts account for more than 30% of all bone marrow nucleated cells It is necessary for the diagnosis of acute leukemia.
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