What are the criteria for complete remission in acute leukemia? 20

The criteria for complete remission of acute leukemia are: 1. Bone marrow image: myeloblasts (type + type) or protomylocyte + protomono + protolyphic + lymph cell count 5%, red blood cells and megakaryocyte lines are normal.

Among them, the proportion of myelocytes in M2B was in the normal range; M3 type medium primitives + early grains 5%; M4 type original grain type + type + original single + young single 5%; M6 type was 5% of the original grain type + type, and the proportion of original red + young red and red was basically normal. The proportions of the mesogranularity and red lines in M7 were normal, and the original giant and juvenile giant basically disappeared. 2. Blood picture: hemoglobin (HB) 100 g L (male) or 90 g L (female and children), absolute neutrophil value, platelet number 100 109 L, no leukemia cells in the classification.

3. Clinical manifestations: no symptoms and signs caused by leukemia invasion, normal life or close to life.

The symptoms of leukemia disappear completely, the absolute value of neutrophils in the peripheral blood, and the absence of sick leukocytes in the leukocyte classification; Bone marrow examination showed 5% of protomyelocytes and lymphocytes, no Auer bodies, and normal erythrocytes and megakaryocytes. In layman's terms, it is the removal of abnormal indications in the peripheral blood and bone marrow that suggest leukemia.

Bone marrow test protomyelocytes, lymphocytes 5%.

Signs and symptoms of leukemia disappear. Peripheral blood neutrophils were 10 L absolute, platelets were 100 10 L, and there were no leukemia cells in the leukocyte differential. Bone marrow progranulocytes + promyelocytes (protomonocytes + promyelocytes or prolycolytica + pralymphoid potato cells) 5%, erythrocytes and megakaryocytes were normal.

No extramedullary leukemia. l, imitation platelets 100 10 l, no leukemia cells in the leukocyte differential.

Answer]: The criteria for complete remission of acute leukemia are: The symptoms and signs of leukemia completely disappear when the socks are closed; The peripheral hemogram is normal, and the cytopenia disappears; The bone marrow is normal and does not have too many blasts.

Answer: A

Analysis: The principles of chemotherapy are: early, combined, adequate, and staged acorn and jujube brigades. Master the knowledge points of "** of rapid rock modified leukemia".

If there is a complete remission, all tests are normal. My sister's leukemia has been out of the hospital for more than four months now, and the day before yesterday she caught a cold, and we were all very anxious, but after two days, she got better, I think this should be called complete relief.

Diagnosis of typical cases based on history, blood count, and bone marrow is not difficult. However, in some cases, the number of peripheral blood white blood cells is normal or decreased in the early stage of the disease, and naïve cells may not appear, which is often misdiagnosed. Therefore, when encountering some suspicious cases, such as unexplained fever, anemia, bleeding, bone and joint pain, hepatosplenic lymphadenopathy, etc., we should be vigilant as soon as possible, and consider leukemia, and do bone marrow aspirate examination in time to confirm the diagnosis.

Bone marrow examination is important for diagnosis, but attention should be paid to the uneven distribution of leukemia cells throughout the body. Atypical cases should be differentiated from the following:

1. Aplastic anemia hemorrhage, anemia, fever and pancytopenia are similar to leukopenia. However, the liver, spleen, and lymph nodes are not enlarged, and there is no increase in naïve cells in the bone marrow.

2. Malignant tumor bone metastasis such as neuroblastoma can cause panecytopenia, and there may be exophthalmos, and special cells may appear in peripheral blood. However, on bone marrow examination, tumor cells are mostly piled up or arranged in a chrysanthemum-like pattern, urine VMA is elevated, and the primary tumor can often be found.

The first two digits are five-two, the middle is three-six-five-zero, and the last is six, and the area code is, zero-one-zero.

The criteria for remission for leukemia are:

1) Complete Remission (CR):

There was no clinical anemia, hemorrhage, infection and intracellular infiltration of leukemia;

hemoglobin volume of blood image 90g l, normal or decreased white blood cells, no naïve cells in classification, platelets 100 109 l; Bone marrow like blasts plus protocytes (or naïve cells) <5%, and the erythrocytic and megakaryocyte systems are normal.

2) Partial Relief:

One or two of the three clinical, hemogram and bone marrow images did not meet the criteria for complete remission, and the blasts and problasts in the bone marrow images < 20%.

3) Unrelieved:

Clinical, hemogram and bone marrow images did not meet the criteria for complete remission, and the blasts and problasts in the bone marrow images were 20%, including those who were ineffective.

Leukemia is the blood system.

The most common malignant disease of COPY is the destruction of normal hematopoietic function due to the proliferation of leukemia cells in the bone marrow. The patient presented with a series of symptoms such as anemia, infection, and infiltration of hemorrhagic organs. If a leukemia patient achieves complete remission after chemotherapy, the patient's symptoms, signs and examinations will appear normal.

There are three criteria for complete remission of leukemia patients: first, the patient does not have any symptoms of discomfort, including no symptoms of anemia, no symptoms of infection, and no symptoms of bleeding.

2. The routine blood examination is completely normal, the number and proportion of white blood cells of the patient are normal, there is no anemia, and the number of platelets is also normal.

3. In the bone marrow examination of the patient, the proportion of blasts plus promyelocytes does not exceed 5%, which is the standard for complete remission of leukemia.

Clinical manifestations include anemia, hemorrhage, fever, and hepatosplenic lymphadenopathy.

Complete blood count: hemoglobin and thrombocytopenia are low, and naïve cells (leukemia cells) can be seen in the white blood cell differential.

Bone marrow aspirate: blasts (leukemia cells) 30%.

Acute leukemia is diagnosed when the blast cells (leukemia cells) in the bone marrow are 20%.

The above standards are currently implemented by countries around the world, and the diagnostic criteria for leukemia (blast 30%) formulated by the World Health Organization (WHO) in 2001 and the FAB Collaboration Group in 1978 have long been abandoned. Therefore, the old standards provided upstairs have long been discontinued, and in order to avoid conceptual errors, they are specially explained here.

More than 5% blasts in the bone marrow or with signs of extramedullary invasion.

**The criterion is that the bone puncture test results show that the sum of naïve cells and blasts is greater than or equal to 5%.

It is recommended to check it out first. Symptoms don't tell the story.

Patients with acute leukemia are considered to be clinical** after stopping chemotherapy for 5 years, and have no disease**, or have survived without disease for 10 years.

The vast majority of clinical** patients have a total number of leukemia cells in the order of magnitude less than 105. Therefore, after stopping chemotherapy, the body's immune system can monitor and inhibit the growth of leukemia cells, and no longer need to rely on chemotherapy to control the progression of leukemia, so as to maintain a stable state of remission of the disease. Sustained complete remission of leukemia and clinical leukemia**, although both belong to the long-term survival state of leukemia, are not equivalent to the two.

Only when the chemotherapy is terminated in patients with sustained complete remission, and the leukemia is not ** for more than 5 years, can it be regarded as clinical**.

7. Why do you need to do lumbar puncture examination and intrathecal injection of drugs for patients with acute leukemia**Acute leukemia can invade various tissues and organs of the body, among which acute lymphoblastic leukemia often infiltrates the central nervous system and can occur at any stage of the leukemia course. Some patients come to the hospital with headache, vomiting, cranial nerve palsy, and even loss of consciousness, and a few are mistaken for meningitis. Therefore, patients with acute lymphoblastic leukemia should routinely undergo a lumbar puncture, if the patient has developed a central nervous system infiltration, it should be active**, and patients with no leukemia cells in the cerebrospinal fluid should also be injected intrathecally for prophylaxis**.

Once central nervous system leukemia is confirmed, patients can undergo spinal (intrathecal) injections, such as methotrexate, cytarabine and other chemotherapy drugs, as well as radiotherapy of the whole brain and spinal cord.