Why doesn t the rabies virus die out with evolution?

At present, from the evolutionary molecular clock, it is believed that the current epidemic has a history of about 500 years (or 1500 years, I forgot the specific time), and the rabies virus is not pathogenic in bats (most viruses in bats are not pathogenic to bats), but there will be a specific adaptation process after jumping to other mammalian hosts, but because the animals infected by the virus will eventually die, the maintenance of the virus population requires a certain number of animals, such as an Ethiopian wolf in Africa, Because the rabies virus is about to become extinct. The adapted rabies virus will also die out due to the insufficient number of animal populations, such as the rabies virus that was endemic in the Middle East in ancient times, but there will also be other viruses that jump out of bats, so the epidemic street virus rabies virus will basically not die out. <>

The ability of a virus to spread, infect, and cause disease is critical to whether the virus can be preserved during its evolution. In general, viruses that are highly transmissible (e.g., airborne), infective (strong binding to host cell receptors and adaptation to host cells), and low pathogenicity to the host are more likely to be retained during evolution. However, in fact, many viruses that are not highly transmissible (such as HIV, HCV, and HBV, which are not very transmissible are relatively speaking) and highly lethal viruses (such as rabies virus).

It can also be preserved, because the transmissibility, infectivity and pathogenicity can "complement each other". The rabies virus kills almost 100% of the host, but the rabies virus "controls" the host's central nervous system.

Causes the host to become more aggressive, allowing it to spread itself to a new host before the host dies. <>

The rabies virus is a ribonucleic acid rhabdovirus with a rounded and convex end; One end is flat-concave, shaped like a bullet, with a diameter of 65-80 nm and a length of about 130 240 nm. The virus is easily inactivated by sunlight, ultraviolet rays, formaldehyde, mercury-liter quaternary amines (such as Xinjieer), lipid solvents, 50%-70% alcohol, etc., and its suspension is inactivated after 56 30-60 minutes or 100 2 minutes. Viruses remain viable for several years when placed in -70 or lyophilized post-0-4.

Infected tissue can be stored in 50% glycerol and sent for testing. Rabies virus contains five proteins, namely glycoprotein (G), nucleoprotein (N), dimer (L), phosphoprotein (NS) and matrix (M). The latter two are small molecule proteins.

G can lead to the formation of neutralizing antibodies in the body, which can fight the viral attack. n, but not neutralizing, can be detected for intraplasmic inclusions.

Rabies is a zoonotic infectious disease caused by the rabies virus. Long before the discovery of the virus in 1884, the French scientist Pasteur discovered the rabies vaccine. <>

The rabies virus is affected by blood, edema and microhemorrhage, and non-specific degeneration and inflammatory changes can be seen under the microscope, such as nerve cell vacuole formation, hyaline degeneration and chromatin breakdown, and perivascular monocyte infiltration. All of these lesions are nonspecific, but in the cytoplasm of nerve cells in 80% of patients, a specific and diagnostic eosinophilic inclusion called a negribody can be found. The inner body is round or oval in shape, about 3 10 nm in diameter, with neat margins, and 1-2 small dots resembling nuclei, most commonly found in nerve cells of hippocampus and cerebellar Purkinje tissues. It can also be detected in the cone cell layer of the cerebral cortex, spinal cord nerve cells, posterior horn ganglia, retinal nerve cell layer, sympathetic ganglia, etc.

Endophyllite is actually a colony of the virus, and electron microscopy can be seen to contain baculovirus particles in the small body. <>

Yes, rabies is a living thing.

Rabies virus belongs to the genus Rabies Virus in the family Rhabdoviridae. The shape is elastic, the nucleocapsid is helical symmetrical, and the surface has an envelope containing single-stranded RNA. It is the causative agent that causes rabies.

Rabies virus has two main antigens: one is the glycoprotein antigen on the outer membrane of the virus, which can bind to acetylcholine receptors to make the virus neurotoxic, and make the body produce neutralizing antibodies and hemagglutination inhibition antibodies, neutralizing antibodies have a protective effect; The other is the inner layer of nuclear protein antigens, which can cause the body to produce complement-binding antibodies and precipitins, but have no protective effect. Rabies is a zoonotic infectious disease caused by the rabies virus.

Tell a thing, if the dog bites you and does not die within 24 hours, your chance of getting rabies is almost zero, and the two vaccinations really have no effect at all, for the insurance to be fully vaccinated, because there are only two diseases in the world with a mortality rate of 100%, one is AIDS, and the other is rabies, the next time someone is bitten by a dog, tell him that the doctor will let you get a few injections.

The first question: the rabies virus will not survive when exposed to air, and it is not known how long it will live, the virus will only be in the saliva of dogs. But it didn't last long.

The second question: a hand wound touching a 24-hour garment that has been licked by a dog can tell you unequivocally that you will not be infected.

Analysis of the condition shouted repentance:

Hello, according to what you said, you have only been vaccinated with two shots of rabies, which does not play a role in preventing rabies, and this time you were bitten again, and you need to be re-vaccinated.

Guidance: The doctor did not say that Zheng Zheng was wrong, if you still only plant two shots, it is equal to the white race, because the rabid vaccine must be fully vaccinated to produce residual imitation antibodies, this is why the doctor let you plant five shots, rabies can be prevented and incurable, maybe, you are lucky, can not cause rabies, but in case of illness, so only vaccination is the safest way.