What to look out for when using glucocorticoids to treat infections

Glucocorticoids are mainly used for patients who are poisoned ** or accompanied by shock at the same time, and glucocorticoids can be used as an adjunct to the application of effective antibacterial drugs** infection at the same time** Because it can increase the body's tolerance to harmful substances, reduce toxic reactions, and help buy time! However, the landlord noted that glucocorticoids cannot be used for viral infection, because the application of glucocorticoids during viral infection will reduce the body's resistance and spread the infection!! As for the question of how to use it correctly, it is not very good, I don't know what causes the infection, if it is an infection caused by a chronic disease, it is generally used in severe cases with a large dose of shock**, commonly used intravenous administration of hydrocortisone, the first dose is 200 300 mg, the daily dose can exceed one gram, and then gradually reduce the dose, the course of treatment is three to five days When applying a large dose, it is best to combine the application of aluminum hydroxide gel to prevent acute gastrointestinal bleeding!

If it is nephrotic syndrome or connective tissue disease (such as lupus erythematosus, etc.), you can choose the general dose for a long time**, commonly used oral prednisone, starting with 10 30 mg per day, three times a day, after obtaining satisfactory efficacy, gradually reduce the dose, reduce the dose every three to five days, and decrease by about 20 per day until the minimum effective maintenance amount The minimum effective maintenance amount is determined by clinicians according to the condition

Here, I would also like to remind the landlord that the application of glucocorticoids can not be stopped suddenly, it must be controlled at the minimum effective maintenance amount, and the sudden withdrawal of the drug will cause the patient to have serious symptoms, nausea and vomiting, hypotension and shock, and the consequences are very serious

Here's a reminder!

Answer] :d Infections that can be treated with glucocorticoids**: severe acute infections, such as toxic bacillary dysentery, fulminant meningoepidemic, toxic pneumonia, severe typhoid fever, acute miliary tuberculosis, scarlet fever and abortico-inflammation, etc.

Virus infection generally does not need to be provoked, because it can reduce the body's defense ability and aggravate the spread of infection after touching it. However, it also has the effect of relieving symptoms of severe infectious hepatitis, mumps, measles and Japanese encephalitis. Therefore, option D is chosen.

Answer] :d glucocorticoids can be used for acute severe infections: under the premise of using sufficient and effective antibiotics to control infection at the same time, anti-hole infiltration is used for patients with poisoning or shock, and is not used for general infection, mainly using the anti-inflammatory effects of glucocorticoids, enhancing the body's tolerance to stress, etc., to quickly alleviate severe symptoms and make the body through the dangerous period, so the correct answer is d.

Answer] :d long-term use of glucocorticoids in large quantities can cause a series of adverse reactions, including: inducing aggravation of peptic ulcer, gastrointestinal bleeding, and perforation; induce and aggravate infection; iatrogenic adrenal hypercortex; Causes water and sodium retention, causing hypertension; osteoporosis, muscle atrophy, delayed wound healing; Glucose tolerance is impaired by rock or diabetes.

Long-term use of glucocorticoids has no effect on the liver, heart-shaped organs, and kidneys, so there is no need to frequently check liver function, kidney function, and electrocardiogram. Long-term use of large amounts of glucocorticoids can induce and aggravate infection, especially in people with low resistance, and the use of antibiotics can easily lead to fungal infection. Therefore, D is selected for this question.

a.Enhances antimicrobial effect.

b.Maintain blood sugar levels.

c.Anti-inflammatory, anti-toxic disperse in the air.

d.Enhance the number of neutrophil deficits.

Correct answer: c

Answer] :d glucocorticoids are anti-inflammatory, anti-shock, anti-toxic, reduce the body's response to endotoxin, but do not neutralize endotoxin, do not antibacterial, do not enhance the antibacterial activity of spring orange antibiotics, and do not interfere with the adverse reactions of antibiotics. The purpose of severe infection in combination with antibiotics is to exert its anti-inflammatory, anti-toxic, and anti-shock effects.

Answer]: B This question mainly examines the role of glucocorticoid bonds in septic shock**: glucocorticoids in general doses can enhance the response of vascular smooth muscles to adrenaline, which indirectly increases blood pressure.

Larger doses have the effect of blocking adrenergic receptors, and the splanchnic arterioles can be relieved of spastic contraction, reduce peripheral vascular resistance, improve microcirculation, increase venous return, and normalize blood pressure. In addition, it can also stabilize the lysosomal membrane, making it less prone to rupture, reducing the release of inflammatory mediators and hydrolases, and maintaining mitochondrial function. In addition, it can promote gluconeogenesis and glycogen synthesis, and inhibit the aerobic oxidation and anaerobic digestion of sugar.

Therefore, choose B.

Answer]: a, b, c, d, e

Frequency of use: Usually twice a day. Studies have shown that the frequency of using it three times a day or more does not increase the effect of hormones, but will lead to a higher probability of its occurrence; Woodman parts used:

For the face, folds and other parts, weak hormones should be used; The rest of the parts can be selected with appropriate hormone preparations according to the condition; When you use it, you orange and fierce man: allergic diseases are generally used for about 5 days; Immune diseases are used for a longer period of time. For example, in psoriasis**, the maximum single course of hormones used in the same area is 4 weeks, followed by 2 weeks of moisturizers as intervals; Hormone dosage:

It should be appropriate, and too much and too little is not appropriate for the patient's disease control.